Ukrainian Scientific Medical Youth Journal

12-18

Authors: A.V. Malikov

This article is about structural changes of medullar substance of kidney in case of experimental burn trauma of the skin of rats using the intravenous infusion of colloid-hyperosmolar solution. If was found that Lactoproteinum with sorbitol protects the damage and has a membranoplastic influence on the organic structure. The ability to visualize ways of receipt and distribution of products of biochemical transformations components lactoproteinum with sorbitol in renal medulla material through floue and penetration helps to clarity the effect of localized plasma pathogenetic factors of multiple organ dysfunction, which is the main component of burn disease. Lactoproteinum infusion of sorbitol in streng thening histohematogenous barrier in medulla kidney play an important role. These two components properties lactoproteinum of sorbitol is to explain the basic morphological manifestations his long-term performance. The results are a kind of control and needed for interpretation with mapped data, to the structural components of kidney medulla under conditions infusion of other combined hyperosmolar solution.

23-26

Authors: A.O. Horobets

The article is dedicated to problems of gluten-sensitive enteropathy (celiac disease) appearing nowadays on modern stage of pediatric science development. In particular, special attention is paid on the rate of non-diagnosed cases of the disease, the problem of violation of gluten-free diet by children with following reflection of this phenomenon and the problem of celiac diseases diagnosing several months and, sometimes, years after gluten-free diet prescription which complicates diagnostics and makes it impossible in some cases. Gluten related disorders – the problem which is being actively investigated and discussed by scientists world wide – is described in the article as well. Such gluten related disorders as gluten sensitivity without celiac disease and food allergy to cereals’ proteins are discussed and differentiated with celiac disease. The problem of celiac disease accompanied by concomitant pathologies, especially exocrine insufficiency of the pancreas, is pointed out besides. It is discussed to be one of prior directions of gluten-sensitive enteropathy problem following study.

31-36

Authors: Oleksandr Dikhtyaruk

Acute rhinosinusitis (ARS) in adults is a sudden occurrence of two or more of the symptoms of which one is nasal discharge, facial pain, unilateral or symmetrically on both sides, reduction or loss of smell with the proviso that the symptoms persist for at least 12 weeks. Algorithms for the examination and treatment offered in the latest edition of the European conciliation document sinusitis and nasal polyposis (EPOS) 2012 can be used as the basis of patient care protocols in national medical practice.ARS can be caused by viral, bacterial or fungal infections. The main pathogens are: Streptococcus pneumoniae (44%), Haemophilus influenzae (27%), Moraxella catarrhalis (16%), â-hemolytic Streptococcus (7%), BS. Pyogenes (3%), H. Parainfluenzae (2%), S. Aureus (1%). Algorithms examination of ARS includes: medical history and complaints, visual examination of the upper respiratory tract, palpation of the front walls of the paranasal sinuses, optic rhinoscopy, analysis of blood, x-ray examination. Treatment is designed for 7-10 days and includes: antibiotics, topical decongestants, topical corticosteroids, saline solutions, antihistamines, mucolytics, anti-inflammatory, sinus puncture. The modern concept of antibiotic therapy patients – SMART – use. International Association of IDSA and EPOS recommend: Amoxicillin/clavulanate – first-line antibiotics, second- or third-generation cephalosporins and macrolide antibiotic – second-line antibiotics, antibiotic of reserves – respiratory fluoroquinolones.

40-43

Authors: V.S. Melnyk

The research activity of fibrinolysis in 123 patients with ischemic stroke, of which 65 (52.8%) women and 58 (47.2%) males, mean age 72,6 ± 11,5 years. Main parameters evaluated fibrinolysis system (t-PA concentration and PAI-1 activity and plasminogen á2- antiplasmin, euglobulin lysis time determination and Hageman-dependent fibrinolysis). The highest activity of plasminogen was detected in patients who have ischemic stroke arose from 06:00 to 11:59 (89,42 ± 13,5%, 95% CI 85,35-93,49) and from 18:00 to 23: 59 (87,88 ± 8,8%, 95% CI 84,74-91,01), the lowest activity - from 24:00 to 5:59 (83,56 ± 6,1%, 95% CI 80, 31- 86.82). The activity of alpha- 2 antiplasmin also had some differences - the highest activity was registered from 24:00 to 5:59 (85,38 ± 4,7%, 95% CI 82,84-87,91), lowest at 18:00 59 to 23 (84,21 ± 10,0%, 95% CI 80,65-87,77). In cases patsentov from 06:00 to 11:59 was recorded the lowest average level of fibrinolysis activator t-PA 0,045 ± 0,02 USD / Ml (95% CI 0,039-0,052) and high concentrations of its inhibitor PAI-1 0,113 ± 0,05 USD / Ml (95% CI 0,099-0,128). Inhibition of fibrinolysis, was confirmed by the increase in lysis time euglobulin (7,97 ± 0,71 hours, 95% CI 7,76-8,19) and Hagemann-dependent fibrinolysis (23,09 ± 2,79 m, 95% CI 22,25-23,93). The activity of the fibrinolysis system in patients with ischemic stroke tsirkazhdni has certain peculiarities. The highest activity of plasminogen, amid lower t-PA concentration and high content of PAI-1 is registered in patients stricken from 06:00 to 11:59. These changes are responsible for a significant extension of the clot lysis time euglobulin and Hagemann-dependent fibrinolysis.

49-53

Authors: Prystupiuk M.O.

To investigate the clinical efficacy of the treatment of patients with neuroishemic diabetic foot ulcers (DF) by using nano-dispersed antimicrobial compositions based on silica sorbents. We observed 78 patients, 27 male (35%) and 51 female (65%). Diagnosis of DF was carried out in accordance with the International Consensus on the Diabetic Foot. Status of the main blood flow in the lower limbs were assessed in terms of ankle-brachial index. Patients received a complex treatment protocols in accordance with Ministry of Health Ukraine. Prescribed broad-spectrum antibiotics, derivatives of thioctic acid, neurotropic vitamin preparations, antiplatelet effects. Compensation of diabetes carried out by insulin. Patients were divided into 2 groups, the treatment group without the use of applicative sorption and group using applications on the sorption-ulcer antibacterial nanocomposite. Treatment is considered effective when complete epithelialization ulcers. Statistical processing of the results of research carried out by methods of parametric statistics. The results of the study on the use of treatment of necrotic ulcers in patients with diabetic foot show declines in terms of ulcer healing in patients treated with applications of sorptionantibacterial nanocomposite. Full-epithelialization of ulcers is achieved by an average of 10 days faster than treatments ulcers without applicative sorption. The duration of treatment for patients with neuroischemic diabetic foot ulcer increases after 70 years in male and female. The use of antimicrobial compositions based on nanosized silica shortens complete epithelialization of ulcers an average of 10 days compared with the treatment of patients with no applicative sorption.

58-62

Authors: D. Pavlenko

Every year almost 10 million patients are registered with ophthalmic herpes. Herpetic keratitis is associated with more than 66,8% of the entire cornea pathology, 55,1% of all ulcerative lesions and it causes more than 60% of the corneal blindness, the recurrence rates in 20-75%. The most common pathogen of the herpetic keratitis is the herpes simplex virus - it is revealed in 50% of adults and 70-80% of children.Quite often, successful drug treatment of diseases depends not only on the proper doctor’s prescription drugs, but also on the patient’s compliance. According to the World Health Organization, about half of chronic patients do not fully comply with medical prescriptions and recommendations, about 50% of patients discontinue therapy within 6 months from the beginning, and only 15% continue treatment for a year. Now the main links of etiopathogenesis, clinical features are studied and treatment regimens of herpetic keratitis are developed, but the role of compliance of the patient during the disease is poorly studied. In this clinical case of recurrent herpetic keratitis flow tree shows the important role of compliance as a factor in the effectiveness of treatment of the patient. The patient was hospitalizes with of the recurrent course of superficial epithelial dendritic herpetic keratitis. Reduction of compliance of the patient led to the complicated course of the disease in the form of rerecurrence with ulceration of the cornea. Due to the combined treatment and awareness of compliance we were able to stabilize the herpetic keratitis and prevent complications.Therefore, while prescribing complex treatment attention must be payed to the observance of the patient’s compliance. Increased compliance is one of the effectiveness factors, which allows achieving a more favorable course, reducing the terms of treatment, decrease and preventing complications, relapses and the need of re-hospitalization.

68-75

Authors: Cherkasov E.V.

In the article presents the results of study the cell death and of the kinetics of cell cycle indicators thymus cells of rats during burn disease after thermal burn injury of the skin on the background of treatment with 0,9% solution of NaCl, drugs lactoprotein with sorbitol or HAES-LX 5%. Burn injuryof the skin on the background of treatment with 0,9% solution of NaCl leads to disruption of the cell cycle of the thymus cells is most higle expressed at 1 and 3 day observation. The use lactoprotein with sorbitol or HAES-LX- 5% can significantly improve the performance of the cell cecle of the thymus cell and reduce the negative impact of burn injury: lactoprotein with sorbitol affects on DNA synthesis (s-phase), and the drug HAES-LX-5% affects on apoptosis that manifests a decrease in DNA fragmentation (SUB-G0G1).

80-84

Authors: V. G. Stolyar, A. V. Borysenko, À. Ð. Levitsky

During the dental implantation quite often develope an inflammatory process in the bone tissue around the implant. For the prevention and treatment of the inflammatory process proposed oral gel. It consists of osteovit, propolis tincture, Metrogil-Denta, chlorhexidine and silicon dioxide. This composition has antibacterial and anti-inflammatory effect. At experimental conditions anti-inflammatory effect of this composition on the inflammatory process in the periodontium were studied. Experiments were performed on 32 Wistar rats which were administered with food prednisolone at 5 mg/kg for 14 days. Part of the rats received daily applications of oral gel containing propolis, osteovit, metrogil, chlorhexidine, silicon dioxide. As a comparison, the drug ointment Mefenat was used. The results were studied using histologic and biochemical techniques. The following parameters were investigated: the degree of atrophy of the alveolar bone, the level of markers of inflammation in the gingiva (MDA, elastase), microbial contamination (urease), nonspecific immunity (lysozyme), antioxidant defenses (catalase), permeability of histohematic barriers (hyaluronic acid). Prednisolone administration with food causes the development of inflammation in periodontal tissue of rats. After the application of drug compositions pathohistological examination revealed the presence of anti-inflammatory effect of the composition. This medicamental composition in rats with prednisoloneperiodontitis reduces the activity of acid phosphatase, increases the ratio of alkaline phosphatase/acid phosphatase and mineralization, reduces the degree of atrophy of the alveolar bone. The experimental pathohistological and biochemical investigations revealed the presence of anti-inflammatory drug action in the proposed medicamental composition.

92-95

Authors: M. Dronova, Z. Suvorova , A. Tsykoza, N. Vrynchanu

Derivatives of 4- (1,1,3,3-tetramethyl butyl) phenoxy-3-(N-alkyl amino)-2-propanol are the novel class of antimicrobial agents, possessing pronounce inhibitory activity against bacteria and fungi. KVM-194 was found to be one of the most promising compounds of this class, preliminary experiments demonstrated its broad spectrum of activity against planktonic microorganisms and biofilms. The aim of the present study was to investigate the development of resistance to KVM-194 in bacteria and fungi. Staphylococcus aureus and Candida albicans were used in all experiments. Microorganisms were grown on the nutrient agar in the presence of subinhibitory concentration of compound. Susceptibility of bacteria and fungi to KVM-194 and officinal antimicrobials was tested every 5 passages. The antimicrobial activity of the 4- (1,1,3,3-tetrametylbutyl) phenoxy-3-(N-alkyl)-2-propanol derivative was investigated by serial broth dilution method. Susceptibility of bacteria and fungi to the officinal antimicrobials was tested by disk diffusion assay. The data obtained suggest no significant changes of C. albicans and S. aureus susceptibility to KVM-194 for 20 passages in the presence of compound. Further studies showed that clotrimazole action on C. albicans was not affected in the experimental conditions, while polyene antimycotics (nystatin and amphotericin B) demonstrate even slightly higher activity. Bacteria S. aureus, grown in the presence of KVM-194, showed no changes in susceptibility to levofloxacin, oxacillin, clindamycin and erythromycin. Thus, obtained results suggest a slow development of KVM-194 resistance in bacteria and fungi and a lack of crossresistance between the compound and officinal antimicrobial agents.

100-104

Authors: V. Kultenko

This article describes negative influence of anxiety-phobic disorders on the person who suffered initial cardiac attack, for which significant influence is made by negative emotional distress (anxiety, depression, anxiety). And creation of psycho-correction algorithm to prevent the development and complication of somatoform disorders. Creating methods of psychological correction and adapting the patients with existing minor malfunction of the cardiovascular system, and with severe somatoform disorders. In the result of the study it is noted the relationship between the change in the psychological and cognitive functioning, mood disorders, somatization, catostrophizing regarding further changes in visceral interoception under the influence of negative emotions and stress. Providing effective and timely cognitive-behavioral therapy (correction), methods of reflection and relaxation with clear adherence of the day, exercises in combination with the minimum doses of medicine therapy leads to a substantial increase of the health level of patients, higher level of self-conception and belief in a positive future and a reduction of anxiety-phobic symptom. Cognitive behavior therapy and psychological analysis of patients‘ behavior features in difficult situations allows to prognosis successful adaptation to the disease in posthospital period and rate the risk of unfavorable dynamics of the disease, prevent recurrence of the disease.

110-113

Authors: E. Shapochka, O. Fitkalo

The problem of alcohol dependence is discussed among the health professions, state leaders and the general population for quite a long time. The present article deals with the theoretical developments of using psychological factors of remission in alcohol addicted patients. The scientific approaches have been investigated to develop an effective rehabilitation program. The aim of this program is to achieve long-term and highquality remission among patients with alcohol dependence.

118-121

Authors: A.V. Kovalchuk, L.A. Cherkasova, A.J.Yanchyshyn

History of Ukrainian science is rich in names of people who were able to significantly accelerate its progress and promote significant achievements. One of these was Vladimir A. Betz - Professor, Head of the Department of Anatomy of the Kiev Imperial University of St. Vladimir for 22 years (1868-1890). During his scientific activity at the university, VA Betz has written a lot of work, but most znachuschee his discovery was connected with the study of the structure of the central nervous system. Open them giant pyramidal cells in the 5th layer of the cerebral cortex, known as Betz cells, clarified the anatomy and physiology, in a complex, and at the same time interesting systems of the human body, as well as become an impetus for the further development of the global and modern neuroanatomy, in particular. Today, throughout the world there is no textbook on anatomy, histology, physiology and neurology, which would not have described these cells. For his discovery, VA Betz was awarded numerous medals and awards, received repeated offers to sell his collection of drugs that he himself has made. However, Vladimir A. Betz as a dedicated patriot of his country, has presented all the materials department of human anatomy, where he worked all his life. This article reflects the main milestones of the life of the scientist, as well as the discovery of the giant pyramidal cells.

10-15

Authors: S. Lytvynyuk

In the experiment on white laboratory rats histological and morphometric study of neurocytes of hippocampal field CA1 was performed after severe thermal injury. It was established that deep burns cause a significant decrease of the numerical density of neurocytes, increase the number of hypo- and hyperchromic cells, the degree of damage depends on the term of the experiment, the most damage of neurocyte and morphometric changes were revealed at the stage of septicotoxemia of burn disease.

26-30

Authors: O. Tymochshuk

The success of the practical use of HTS materials depends on many interrelated properties of superconductors. These properties has chemical stability. That is why the question of stabilizing the superconducting properties of HTSC compounds has a very important practical significance. The effect of substitution of Ln for the rare earth elements was analysed, it is an important element in deciding ho whether to improve technical characteristics of superconducting materials. The synthesis of samples was made in systems Er1- xAxBa2Cu3Oy (A = Pr, Tb, Ce: 0,05d”xd”0,5) by ceramic technology. In each system radiographic study of the synthesized compounds was performed, oxygen content was determined and dependence of its content on the degree of substitution of REE, which is an important element in deciding whether to improve technical characteristics of superconducting materials and further development of scientific ideas and material science. Well known that the change of oxygen content in compounds Ln123, caused by heat treatment, leads to structural phase transitions, which are closely related to changes in the electronic and magnetic properties. The increase in concentration of intercalated oxygen in intercalated basis CuO planes causes the increase of oxygen index y. Twodimensional Ising model was used to describe the process of filling CuO layers with oxygen and the formation of ordered structures in a number of works, which allowed to calculate the phase diagrams of the synthesized compounds. Well known that an increasing number of intercalated oxygen Ln123 causes to increasing concentration of free carriers (holes) in proportion to changes in oxygen index. However, a phase semiconductor-metal transition occurs on the verge of transition from tetragonal phase to rhombic and disappearance of antiferromagnetic ordering in the CuO layers. It is showing in the concentration dependences of properties such as conductivity, permittivity and magnetic susceptibility. Electrical conductivity of the samples was studied and the dependence of the superconducting properties of the type of replacement atoms was found.

37-41

Authors: M. Sharayeva

Two cases of non-effusive pericarditis associated with serologically proven Epstein - Barr virus were reported. Almost healthy young males had complaints of abrupt onset of retrosternal chest pain that appeared during breathing or moving. Other common causes of chest pain must be ruled out, including cardiac ischemia, pneumonia, costochondritis, pulmonary embolism and substance abuse (cocaine). The past medical history were unremarkable, they denies recent use of medications. During physical exanimation a pericardial friction rub was not heard, X-ray was normal. The 2015 updated European Society of Cardiologists Guidelines for the diagnosis and management of pericardial diseases recommended ECG, Echo, measurement of inflammatory or myocardial injury markers. The presentation and discussion of ECG typical changes and Echo signs that proved diagnosis of acute pericarditis were reported. Potential causes of pericarditis are numerous and include trauma, viral infection, tuberculosis, malignant disease and autoimmune conditions. The search for causative factors is often fruitless, because the condition is deemed to be idiopathic. It is common that viruses can lead to acute pericarditis, but only few cases of EBV-associated pericarditis have been previously published. Broad serological tests of infectious diseases were taken. EBV-associated effusive or non-effusive pericarditis may develop without any signs of the infectious mononucleosis in young and almost healthy patients. Both patients made a good physical recovery after being placed on special non-steroid anti-inflammatory drugs, colchicine therapy.

47-50

Authors: A. Mazur, M.Andrienko

This article presents the results of esofagus scintigraphy in 98 patients with different pathology of upper gastrointestinal tract : 48 men and 50 women aged from 14 to 64 years. Half of them, mainly with functional dyspepsia (FD) (18.4%), was showed slow passage of the radiopharmaceutical preparation (RPHP) through the esophagus, accompanied by a decrease in its clearance of up to 60%. Narrowing of the esophagus and local suprastenostic delay of RPHP > 12 sec was observed in 29.6% of patients: with Mts in hilar lymphatic nodes (HLN) with esophageal varices (EV) and esophageal cancer (EC). In 3 patients with Mts in HLN RPHP was delayed > 20 sec with a deviation of the esophagus to the left on the border of the upper and middle thirds. Gastroesophageal reflux disease was diagnosed in 53 studied: with ulcer disease (20.4%) with a functional dyspepsia (FD) (19.4%) with chronic gastritis (7.2%), with cholecystitis (5.7%) and two with esophageal and stomach cancer. Scintigraphic signs of gastroesophageal reflux were antiphase change of curves on the definition of the second study, in excess of its activity for more than 5% of the activity of the stomach, it was considered pathological.

63-66

Authors: I. Y. Katsitadze

Purpose: To compare the effects of the same resting heart rate using as a combination of ivabradine and bisoprolol (BS) and uptitration Bs on exercise tolerance, its chronotropic support of LV systolic function and NT proBNP in patients with chronic ischemic heart disease with moderate heart failure and systolic dysfunction of the left ventricle (LV). Methods: In this blind, parallel-group study included 52 patients aged <60 years (54 ± 2,3) with sinus rhythm> 70 beats per minute with coronary artery disease (stable angina CCS class I- II), to document infarction> 3 months mild hypertension and approximate 38-45% of the PV taking ACE inhibitors and BB 2.5 mg / d. In group 1 (n = 40) was dotitrovan BS to 5 mg / d and Iv was added (5 mg to 7 5 mg twice, 12,4 ± 0.49 mg / day), Group 2 (n = 38) BS titrated to 10 mg / d (9,1 ± 0.35 mg / d). At the beginning of the study (M0) and 2-months (M2), the patients underwent treadmill- test - TT (Bruce protocol) was measured by ejection fraction, the velocity of the mitral annulus, the ratio of the flow rate to the speed of the ring (were rated E / E ') of using TDI and plasma NT proBNP was measured by ELISA. Results. Resting heart rate and systolic blood pressure were similar in both groups at M0 (78,6 ± 3,59 versus 81,4± ± 3,7 beats and 135,4 ± 5,8 versus 132,4 ± 5,8 mm Hg. In.) and M2 (66,4 ± 2,93 64,9 ± 2,91 against and beats against 124,2 ± 5,4 125,2 ± 5,7 mm Hg, p> 0, 05) . Fatigue and / or shortness of breath dominated the reasons for stopping the TT both groups at M0 (55% vs. 47.5%) and M2 (68.6% vs. 60%). Conclusions: In patients <60 years with coronary heart disease and moderately reduced vWF equivalent control heart rate at rest after 2 months, treatment with the combination of ivabradine and bisoprolol, compared with monotherapy with bisoprolol was associated with an improvement in exercise tolerance, despite the increase in chronotropic reserve and and improved systolic function in terms of tissue Doppler and decreased plasma NT proBNP in the absence of significant changes in ejection fraction. Key words: heart rate, heart failure, exercise tolerance, bisoprolol, ivabradine.

73-76

Authors: I. Novarchuk

Resection pancreas is the only effective treatment for a number of malignancies biliopankreato- duodenal zone and complicated forms of chronic pancreatitis. Type 3 Diabetes is a major factor affecting the quality of life of patients who underwent resection of the pancreas. Cases of diabetes are 3 types depend on the type of surgery, degree of resection and software as abandoned gland tissue. In our study, was recorded a clear association of diabetes with 3 types of postoperative complications. We believe that rational surgical tactics, adequate preoperative preparation will certainly affect the reduction in the risk of developing diabetes type 3

83-90

Authors: I. V. Poladich

The issue of multiple pregnancy continues to maintain its relevance and status of the priorities of modern obstetrics, thanks to a stable high frequency in the population and in the world. According to the observations, only for the period from 2000 to 2010 year Ukraine has seen an increase in the frequency of multiple births by more than 30%, while deliveries with twins account for nearly 95% and the remaining 5% are triplets birth and multiple pregn of higher order. Multiple pregnancy contributes to significant morbidity and adverse pregnancy outcomes for the mother and for the newborn. Maternal morbidity in multiple pregnancies (BV) increases in 3-7 times, and the associated material costs of health care, increased by more than 40% compared with a singleton pregnancy and childbirth. Compared with singleton pregnancy at BV complications occur more often before, are characterized by a severe and prolonged course. Perinatal mortality in pregnancy with twins is 5 times higher than in singleton pregnancies, intrauterine fetal death is 4 times higher, neonatal - 6 times, perinatal - 10 times. Despite numerous published data, in obstetric practice, there are no clear recommendations for the effective management of multiple pregnancy at different stages of gestation, depending on fertilization - spontaneous or as a result of assisted reproductive technology. The algorithm is a multiple pregnancy antenatal care should be based on the early formation of the risk of preterm birth and possible development of perinatal complications. However, there are some controversial issues concerning the diagnosis and management of these women require a more thorough study of occurrence of these pregnancies, identify risk factors and optimization tactics of pregnancy and childbirth. Key words: multiple pregnancy, twins, assisted

95-98

Authors: V. Tereshchenko, V. Stepanenko, K. Kolyadenko

The article provides information about molluscum contagiosum and shows the necessity of efficient method of therapy of molluscum contagiosum in childhood. Molluscum contagiosum - a contagious viral skin infection, which is caused by Molluscum contagiosum virus, results in round, small, firm, flesh-colored bumps. Knowledge of this disease in medical practice is necessary because it is one of fifty most common diseases in the world, and more often occurs in age one to ten. In addition, every year from two to ten percent of new infections in children appear. So, the molluscum contagiosum is highly contagious, but is not dangerous because it does not lead to serious or fatal complications. The main goal of treatment of this disease - is removal of the soft center of each skin element of the rash, after which they resolve. Despite the availability of a sufficient number of treatment of molluscum contagiosum, there is no consensus on medical treatment. Most of methods of treatments of molluscum contagiosum have disadvantages. It is important to remember in children's treatment because therapy of this disease could cause unfavorable psychological and physiological reaction in child's body. However, single use of a pulsed dye laser (PDL) with a peak wavelength of 580590 nm provides a quick positive effect and also it is safe in treating of molluscum contagiosum in childhood because of causing less children's fear and is less painful.

103-107

Authors: O. A. Chernichenko, KS. Sakalo, A.V. Sakalo

There were violations of bone mineral density determined by bone densitometry in 82 patients with prostate cancer receiving the hormone therapy. The significant percentage of patients has been diagnosed with osteopenia II-III types (19,7%) and osteoporosis (5,9%), which needed to prescribe the inhibitors of bone resorption. The administration of zolendronic acid in combination with denosumab has showed the significantly beneficial effect on increasing bone mineral density.

123-128

Authors: Gordeychuk M.A.

Globulomaxilla cyst - a cyst neodontogen- naya jawbone . It has a slow growth asymptomatic and detected incidentally . That is why the use of modern methods of diagnosis , such as computed tomography , are very important in the preparation of the patient's dental treatment . Holding, during the preparation of the patient, computed tomography allowed to detect and treat the disease, which is not allowed to be in the future plan of dental implantation and prosthetics with removable reliance on dental implants.

129-133

Authors: M.V. Syroishko, N.A. Zelinska, M.Yu. Antonenko

The study involved 120 patients with GP I-II degree, chronic course, in the age of 26-35 years (study group). Control group consisted of 54 patients with clinically intact periodontium. The patients of the main group were divided into subgroups: A primary (57), where the background of DTH to microbial antigens and bone in preoperative preparation scheme include specific microbial desensitization method followed by immunization; main B distinguished by the fact that this method of correction they are not carried out (due to failure patients). Specific microbial desensitization followed by immunization was carried out with the help of the adsorbed staphylococcus toxoid and streptolysin-O. According RTML patients with major groups A and B to the HRT streptococcus was found in 70,8 ± 1,81%, P <0.01 observations against 25,9 ± 0,75% in the control group. By antigen Staphylococcus - from 49,2 ± 4,2% P <0.01, in control - 0. We have found positive effects of the method specific microbial desensitization followed by immunization at 84,2 ± 0,23% in the main and the group. Without the use of this method (basic group B) efficiency was 39,7 ± 0,24%.

134-140

Authors: I. Sakhanda, M.Syatynya

The article presents the results of a study of herbal medicines for the treatment of cardiovascular diseases. We studied the motivational preferences of consumers. To obtain representative data in the course of sociological research methods used the method of random sampling without repetitions.

141-145

Authors: V. Vedeneev, D. Vedeneev

This article first introduces into research soviet state security bodies surveillance materials of outstanding scientist-ophthalmologist, academician V.P Filatov. They contain valuable information about organization, scientific research and foreign security services interest to innovative scientific and technological developments of Odessa experimental ophthalmological institute (established by V.P Filatov). Materials give evidence about high culture level, religiousness of scientist, his patriotism and devotion to medicine, despite anti-soviet beliefs and political persecution. Security services reports contain a lot of information about Filatov's scientific achievements, his science school formation, relationship with governments and hierarchs of Orthodox Church including Crimean bishop Luke (Voino- Yasenetsky).

11-14

Authors: Dzevulska I.

Microscopic study in rats, which after burns of the skin 2-3 degrees 21-23% of the surface area of the body were injected the first seven days Lactoproteinum with sorbitol solution at a dose of 10 ml per kg show that microcirculatory disorders, degenerative and necrobiotic changes in endocrinocytes of glomerular, beam and netted area of cortex and brain substance endocrinocytes within 30 days of the experiment were less pronounced than in rats that after burn skin the first seven days were injected 0.9% NaCl solution. Also, unlike the rats that after burn of skin the first seven days injected 0.9% NaCl solution, the injection of Lactoproteinum with sorbitol solution 14 days after the burn of skin in foci of necrosis was present hypertrophy and hyperplasia of fibroblasts and after 21 and 30 days after skin burn - in the connective tissue of cortical and adrenal medulla manifestations of multiple sclerosis are less pronounced.

20-29

Authors: T.Panova, M. Kîshelnik, S.Sherbаk, G. Bîrtnikova, I.M. Karvatskiy, O. Mozheitova, O. Moroz

Different medicines that affect distinct mechanisms of the arterial pressure diminishing are used in clinic for hypertension treatment - neural, humoral. It is unclear why these drugs display different effect in different patients. Impairment of neural and humoral chains of arterial pressure regulation under hypertony of different etiology is suggested to be unequal. Chronic hypertony of different genesis was developed in rats during 4 months: under alcoholism (n=10) and metabolic obesity (n=10). Emotional stress modeled by introducing caffeine. After that hypotensive medicines of different mechanism of action were administered: Concor cor (beta1-adrenergic receptor blocker), Doxazosin (antagonist of alfa1- adrenergic receptor), Prestarium (inhibitor of ACE). These drugs were applied separately of under the stress made by caffeine. Arterial pressure on the tail and the heart rate were registered using sphygmomanometer.

36-39

Authors: O. Mitina

The article is devoted to the problem of the sanitary ecological state of recreational areas. An author on the basis of empiric research's result was developed the draft of comprehensive assessment of the sanitary ecological state of coastal recreational areas. This scheme proposes an analysis of recreational loading and recreants' opinion poll on the issue of the environmental quality and the study of the most important indicators of sea water, sediment, contamination of beach sand by household waste and staging experiments by bioindication with typical representatives of coastal recreational areas. Statistical analysis of the results showed that the most pronounced differences in terms of total suspended solids and solid waste in the area of the beach Omega in compare with the beaches of the north part of Sevastopol, whereas the most pronounced correlation between the indices of the total suspended solids and content of sea water's oxygen (r = -0,965), as well as the total suspended solids and the amount of garbage on the beach (r = 0,753). Between the recreational load and the amount of municipal solid waste has been identified the feedback (r = -0,702). We can assume that this trend is associated with the better cleaning of popular beaches and municipal protection of less visiting areas.

50-54

Authors: S.Tarasenko, V. Smianov, A.Maslenko

In a study to assess the relationship between the number of donors and the amount of blood collected from them in the Sumy region during 2005-2013 years, was used a method of time series analysis and correlation analysis (calculated Spearman rank correlation coefficient). The reliability calculation estimated by calculating the average error rate and reliability. The basis of the study were reporting data of Sumy Regional Blood Transfusion Station and “SOTSSK”. There are such characteristic features of the donation process in Ukraine: 1) insufficient supply of blood, its components and preparations; 2) reducing the “prestige” status of the donation; 3) a small proportion of voluntary unpaid donors in the total amount; 4) the existence of problems with the quality and safety of donated blood; 5) restrictions on the use of effective methods of blood testing. It is proved that the increase in the number of donors in the Sumy region does not cause an increase in blood obtained from donors (Spearman rank correlation coefficient is 0.58, the average error - 0.31 coefficient of reliability - 1.87).bEmphasis in the premises to ensure the quality of blood donation, three levels: system, service, network. At the system level prerequisites that ensure the quality of blood donation, not well defined are the questions of creation of a national registry of donors, the adoption of legislative acts in the field of standardization processes donation, there is no communication strategy to ensure the quality of blood donation. At the service level needs to be improved service organization donors and increase the adequacy of equipment. The network layer is represented by the insufficient number of donors and the need to improve their quality and structural composition. To build a quality management system donation in Sumy region it is necessary prerequisites for development at three levels: system, service and network, allowing purposefully to maintain a certain quality standards in the donation.

58-62

Authors: O. Barabanchyk

To study clinical manifestations in patients with impaired metabolism of uric acid in combination with obesity and non-alcoholic steatohepatitis. The diagnosis of NASH was established on the grounds of exclusion criteria of chronic diffuse liver disease, viral, autoimmune, genetic and medical etiology as the cause of cytolytic syndrome, as well as on the basis of increased echogenicity and decreased conduction liver ultrasound findings. In patients with impaired metabolism of uric acid in combination with obesity and non-alcoholic steatohepatitis noted features such as the presence of clinical manifestations of dyspeptic, abdominal, joint syndrome, and the presence of the phenomenon of “biliary sludge”, which indicates a high risk of developing gallstones.

69-71

Authors: V. Vasyuta

The number of patients with visual impairment in the world is growing steadily. Among the serious ophthalmic disabling diseases special place occupies optic nerve atrophy (ANA). The system of care needs improvement and effective management decisions. Purpose of our study was to justify the management model of medical care to patients with ONA. Materials and methods. The study was based on the experience of providing care to patients with ONA in the department neuroophtalmology SI “Institute of Neurosurgery named after A.P. Romodanov NAMS of Ukraine”. We analyzed data from 4000 patients with ONA, which were sent for further diagnosis and treatment strategy from medical institutions of all levels (primary, secondary and tertiary). We proposed a model management system of medical care patients with ONA. This model has the following elements: organizational, legal, structural and functional, resource economy and takes into account the socio-economic conditions of the region. The basis of organizational and legal integration element is the principle diagnostic and treatment process for optimal interaction between physicians related specialties. Studies management model of medical care to patients with ONA, presented its basic elements, which will optimize the medical assistance given category of patients.

76-78

Authors: Y. Zavodovskyi

. The work is based on the results of examination and treatment of 141 patients treated with renal replacement therapy by PD at the Department of General Surgery and Department of Nephrology of the Oleksandrivska clinical Hospital in Kyiv in the period from 2007 to 2015. Within three years ESI occurred in 67 (47.5%) patients. The most common pathogen in ESI was Staphylococcus aureus - 48 (34.0%) the second most frequently pathogen was Staphylococcus epidermidis - 19 (13.5%). There were no significant differences between categories of ESI and the frequency of infection by various pathogens. After ESI catheter was removed in 12.1% of patients. In all cases of ESI caused by Pseudomas aeroginosa catheter was removed.

85-89

Authors: Kovalenko E., Kovalenko O., Moiseienko V.

This article provides the evidence of the relationship between the meteodependency, as one of the indicators of adaptive reactions of the body, with physical activity and the alarming indicator for the young people. Based on a survey of people aged 17- 25 and its further analytical processing, the results showed that in the non- meteosensitive group the majority of people are engaged in physical activity and vice versa - meteosensitive group consists of people who rearly or never do sports. Perhaps, the physical activity has an adaptogenic effect on the autonomic nervous system due to an improved respiratory function and regulation of vascular tone.

94-97

Authors: I. Kravchenko, N. Turchina

Scapuloperoneal Davidenkovhs myodystro¬phy represents a fairly rare disease nowadays, which diagnosis is sometimes difficult. Scientists still continue to study the characteristics of the mutations that occur in human's body within this disease. Biochemical and pathophysiological processes in the body of patients today have been studied too little. The main problem, which concerns this article, is that the disease in its clinical course may look like Landouzy- Dejerine muscular dystrophy, which occurs much more frequently. The problem becomes more acute because there are controversies among scientists about the place of scapuloperoneal Davidenkovhs myodystrophy amongst others myodystrophies. Some scientists and scientific sources indicate that scapuloperoneal Davidenkovhs myodystrophy is one of the clinical forms of Landouzy- Dejerine muscular dystrophy or a very similar disease. But over the time, the scientists concluded that scapuloperoneal Davidenkovhs myodystrophy is an independent disease, as it has certain features in the clinical course. That is why this article is dedicated to the definition of the main clinical manifestations of scapuloperoneal Davidenkovhs myodystrophy as well as the identification of the main differences of this disease from Landouzy-Dejerine muscular dystrophy. The objects of the study were two families received in patient treatment in the neurological department of the Alexander Hospital: mother and her son, patients with Landouzy-Dejerine muscular dystrophy disease and mother with her daughter with scapuloperoneal Davidenkovhs myodystrophy disease. The results of objective and laboratory researches of these two families, their neurological status, medical history and treatment plan are presented in this article. The Analysis of the survey results of two families has once again shown that both myodystrophies in their clinical flow and development are very similar to each other. Both diseases inherited from the parents of the patients, hit the same muscle groups, are progressing rather slowly, and amenable to symptomatic treatment only. The article describes the clinical and laboratory criteria for differential diagnosis of scapuloperoneal Davidenkovhs myodystrophy and Landouzy-Dejerine muscular dystrophy. On example of clinical cases and also based on review of the medical scientific literature, the main differences between these two diseases are opend. Information on Davidenkovhs myodystrophy, as about an infrequent disease, is also provided separately. Criteria of diagnostics and feature of a clinical course of this disease are also given.

103-106

Authors: E. Nazarenko, A.Radchenko, S. Belal, M. I. Yabluchansky

In 50 patients (25 men and 25 women, mean age - 69,2 ± 12,58 years) with arterial hypertension (AH) influence of biofeedback (BFB) sessions in closed loop of paced breathing (PB) and heart rate variability (HRV) parameters on life quality was studied. All patients were divided into two comparable groups: 1st - 25 patients, where carried out the standard drug therapy, 2nd - 25 patients, where similar treatment was supplemented by 10-day BFB sessions in researched loop with subsequent rhythmic breathing exercises at outpatient stage. Life quality was assessed by questioning of patients before and one month after treatment with the SF-36 questionnaire. The data was processed by parametric and nonparametric statistics. It was found that the systematic BFB sessions in closed loop of PB and HRV significantly improves the life quality of patients with arterial hypertension that allow us to recommend this technique in clinical practice.

115-119

Authors: A. Sakalo

After chemotherapy (ChT) in seminoma patients the residual tumors (RT) of different size and composition could occur. Either ChT or radiotherapy, active surveillance or surgical excision can be administered in this scenario. We present results in 31 patients with RT, and analysis of factors affecting progression. Statistical work out includes logistic regression and Kaplan-Meier analysis. We found that RT sized > 3 cm are more frequently being diagnosed after ChT of disseminated seminoma. When disease progresses (despite salvage- therapy and surgical excision) the prognosis is worse compared to other patients. When alive tumor is found in RT after ChT of second line the prognosis is worse compared to necrosis or fibrosis in the RT. Stage at the beginning of the treatment and spontaneous regression (stabilization of the process) during the follow up are factors confounding the progression. Surgical treatment of RT is technically complicated and associated with high risk of intraoperative complications. Radiotherapy of RT does not improve survival. Long term follow up and active surveillance during many years is justified due to fact of long lasting regression (stabilization) of the RT.

128-131

Authors: V. Revich, T. Shuminska

of blood factors as probable genetic markers investigated tooth decay in 93 people aged 12-14 years. Representation material found on comparative assessment of the frequency of detection of blood groups in 3227 blood donors - residents of Ukraine. Determining genetic markers of blood and saliva conducted in hemagglutination reaction. As a result of genetic and morphological studies the groups at risk of dental caries depending on group membership to the systems ABO (H), P1, MN, Lewis. Found a different structure of enamel, depending on group membership to the ABO system, denser structure of different tooth enamel persons with B5 (III) and ABo (IV) of blood samples of tooth enamel people with O5b (I) and Ab (II) characterized by a loose group structure

138-143

Authors: E. Kovalevskaya, E. Ostapenko, L. Zaprivoda

Department of Histology and Embryology appeared at our university through the work of anatomists. Volodymyr Betz has made an important contribution to the development, so he is fairly called “godfather”. Originally, department located in two classrooms of anatomical corps on Fundukleivska str. (now it is called Bogdana Khmelnitskogo str., 37), but then department was placed in a one-story house nearby. During the evacuation (1941¬1943) department had to be moved into Chelyabinsk. Fortunately, the buildings in Kyiv have been preserved and department has returned in its previous location. When morphological building of the Kiev Medical Institute in Brest-Litovskiy highway 82 (now Peremogi Avenue, 34) was ended, department moved to a new building and is still located there. Everyone who headed the department made an enormous contribution to its development. Only through their efforts the department has become a model, one of the best. Famous histologists: Petro Peremezhko (1868-1891), Yakiv Yakymovych (1891-1904), Fedir Lomynskiy (1905-1924), Olexandr Chernyakhivskiy (1925¬1929), Semen Shahov (1930-1953), Mykola Zazybin (1954¬1975), Kostyantin Kabak (1976-1992) were heads of the department. Since 1992 until now, the department has been being managed by the Corresponding member of NAMN of Ukraine, Professor, MD Yuriy Bogdanovich Chaikovskiy. New scientific discoveries is being made at the department, neyrohistological school continues its life in the works of students and followers. The study of nervous system is continuing, but other systems is being studied too; new embryological research is being held.

10-16

Authors: Kovalchuk A.I. , Cherkasov V.G. , Dzevulska I.V. , Titarenko V.N. , Malikov A.V.

on the experimental model of the local thermal burn we investigated reactive changes of the pituitary-adrenal system in rats. In burned rat installed nonspecific destructive changes parenchymal and stromal elements of the adenohypophysis and adrenal glands. Changes characterized three phases of the development of organ dysfunction: 1-3 days - microcirculatory disorders and degenerative changes of initiation; 7-14 day - the progression of degenerative changes and stabilization; 21- 30 day – activation of regenerative processes and hemodynamics. In the pathogenesis of burn injury leading place has regional hemodynamic changes. Microcirculation disturbance cause ischemic cell injury, development of dystrophic disorders and in critical hypoxia caused tissue necrosis.

19-22

Authors: Khallo O.E.

Chronic hypoxia prostate plays a key role in the development of male infertility. To study the structural features of the parenchyma and bloodstream prostate chronic prostatitis, 9 specimens taken from men 32-38 years old, whose death came not from diseases of the genitourinary system, conducted histopathological study of prostate cancer. Histopathological and by color ultrasound angiography in patients with chronic prostatitis set expressed circulatory disorders and structural changes in the parenchyma and stroma in prostate cancer. In some areas it acinus expanded in connective tissue septa available edema and lymphocytic infiltration, mainly along the blood vessel wall which irregularly thickened and narrowed lumen them by hyperplasia of endothelial cells. The glandular epithelium of the acini flattened, partially desquamated into the lumen. Hyperchromic nuclei of cells, cytoplasm vakuolizovana. Marked increase in the number of vessels in the area of inflammation and lesions near the urethra. The epithelium of the glands cubic or flat. In general, chronic prostatitis varies considerably relationship between parenchyma (56.1%) and stroma (43.9%) body downwards its glandular component. The lumen narrowed glands, glandular epithelium flattened. According to the ultrasonic diagnostic parameters ehometrychni prostate in these conditions significantly increased width – to (51,7 ± 2,5) mm thickness – to (46,4 ± 2,0) mm, length – up (33.2 ± 1,5) mm on average. Twice increased volume (49,7 ± 1,7) cm 3 and weight (51,7 ± 2,0) g (P <0.05) of the prostate. This indicates circulatory disorders in the prostate, which appear arteriospazmom ishemizatsiyeyu parenchyma and peripheral areas with a significant decrease in peak systolic velocity and peak diastolic flow velocity and volume flow.

27-29

Authors: Antonenko E.V. , Zhaboedov G.D

In patients with combined endocrine disorders (type 2 diabetes and hypothyroidism) investigated the state of tear production (Schirmer’s test) and the tear film break time (sample Norn), depending on the level of vitamin D3. It is shown that vitamin D3 deficiency is observed moderate gipolakrimiya, with a deficit – significant.

34-38

Authors: Glushak À.À. , Gunas I.V.

Found that in 86.7% of boys and 83.3% of girls with different craniotypes with orthognathic bite built significant regression models of individual sizes needed to build the correct form of dental arch, depending on the characteristics of the linear dimensions of the teeth of the upper and lower jaw. In most cases, the coefficient of determination R2 has the highest value in boys and girls mesaticephalic (respectively R2 = 0,877-0,977 and 0,934- 0,951). In boys and girls mesa- and brachycephalic most often to the models includes vertical dimensions of the teeth (respectively in boys 59.3, 60.0% and 64.0, 40.0% in girls); in boys hyperbrachycephalic – vestibular-oral dental dimensions (42.9%) and in girls hyperbrachycephalic – mesiodistal size of teeth (42.5%).

43-46

Authors: Kolomytseva I.N. , Yabluchansky N.I. , Volkov D.E. , Lopin D.A.

The study included 43 patients with a permanent pacemaker on the atrio-ventricular block (AV block) and sick sinus node syndrome (SSNS) in the modes of stimulation DDD/R, bradysystolia permanent atrial fibrillation (AF) in the modes of stimulation VVI/R and dilated cardiomyopathy (DCM) in the modes of stimulation CRT-P/D. Hemodynamic parameters were evaluated according to the functional class of chronic heart failure (CHF FC). In the semi-annual period after pacemaker implantation regardless of the mode of stimulation diastolic blood pressure (DBP) and heart rate (HR) were completely normalized in all groups FC CHF, and diastolic blood pressure (SBP), end-systolic and diastolic volumes (EDV and ESV LV) and left ventricular ejection fraction (LVEF) – group I, II CHF FC with a tendency of normalization in groups III, IV FC CHF. The results were the best in the mode of stimulation CRT-P/D. Thickness of posterior wall and interventricular septum of the left ventricle (LV PW and IVS), the size of the left and right atrial (LA and RA), right ventricle (RV) showed only a tendency to reduce irrespective of the CHF FC. It is concluded that the hemodynamic parameters in patients with implanted pacemaker III, IV CHF FC require more active therapeutic monitoring and treatment.

52-57

Authors: Mellina V.

Prisms are used in ophthalmology for the treatment of binocular function for over 100 years. In 1970, the US was reproduced Fresnel lens of 3M Company with a flexible membrane material polyvinyl chloride (Press-On prism). But in our country using “Press-On™ Prism” was limited due to the large value of purchases. In 2006 on the Ukraine presented new modified Fresnel prism made of polimetylmethacrylate. The objective is to study the effect of prism Fresnel binocular function and stereopsis in children. The study involved children aged 5 to 17 years with normal binocular function. Total number of patients 100 people including 44 boys and 56 girls. In study tested prism force ∆5, ∆10, ∆14, ∆18, ∆20, ∆24, ∆28, ∆30. Micro prisms of equal power were installed on one the basis of lens to the outside and the pair of eye the basis of lenses inside. On top of the prism installed red and green lenses of glass set. The survey results show that modified Fresnel prisms face value ∆5; ∆10; ∆14; ∆18; ∆20 have no effect on binocular vision unlike ∆24, ∆28 and ∆30. Acting on fusion, prisms high power causing diplopia phenomenon, and in some cases, lead to the transition from binocular to the simultaneous vision. Also, the modified prisms high power less impact on stereoscopic vision, unlike membrane prisms “Press- On™ Prism”

62-65

Authors: O. B. Nekhanevich

The aim was to establish the dynamics of the systolic and diastolic function of the left ventricle of the heart during exercise of different capacities according to echocardiography in athletes with bicuspid aortic valve. To achieve the objectives we have examined 39 athletes aged 8 to 16 years, who were involved in football. In the study group included 9 athletes with bicuspid aortic valve. In the control group included 30 athletes of appropriate age, sex and sports training with normal aortic valve structure. All athletes echocardiography performed during the execution of exercise on a bicycle ergometer. The results showed that athletes with bicuspid aortic valve at rest characterized by increased aortic diameter and deterioration of left ventricular diastolic function (p<0.05). The threshold of tolerance to physical exertion in athletes with bicuspid aortic valve was statistically significantly lower than the control group at the expense of systolic and diastolic function of the left ventricle. Early symptoms of physical overexertion by cardiovascular system in athletes with bicuspid aortic valve was increasing the ratio E/e’. It can be used to diastolic myocardial function reserve diagnostic.

70-73

Authors: LEV PRYSTUPIUK

Objective. Determine the prevalence of disorders of carbohydrate metabolism in study of ukrainian population. Materials and methods. The study involved 1,148 people, which was measured by glycosylated hemoglobin The results of the study. The highest level of HbAlc was found in 23% of males and 48% of females. Conclusions. 1. The screening of carbohydrate metabolism disorders by definition of HbAlc level reveals an increase the HbAlc level in 23% of males and 48% of females of the study cohort. 2. The greatest number of people with high HbAlc level was observed in the age group above 59 years old. 3. Active detection of violations of carbohydrate metabolism by definition of HbAlc level enables patients to make change lifestyle and begin treatment of undiagnosed type 2 diabetes mellitus, that diminish the negative impact of hyperglycemia and the development of cardiovascular disease. Key words: glycated hemoglobin, type 2 diabetes mellitus, cardiovascular disease.

78-80

Authors: K.A. Chympoy , M.V. Bobyk , K.A. Syrota , I.L. Nemish , N.D. Pavlyukovich

The dynamics of indicators of thyroid homeostasis, pro-and antioxidant system in patients with chronic diffuse liver diseases using of selenium- containing drug “Triovit” has been studied. It has been established, that Triovit in the complex treatment of patients with chronic diffuse liver disease contributes to optimizing thyroid

88-90

Authors: V. Monashnen , N. Gorchakova , I. Chekman

Article is devoted to a new direction of nanopharmacology – functioning nanoparticles, nanocom- posites comprising nanomotors that mimic the dynamics of natural motors. The natural nanomotors include ATP-ase. Degree of activation of ATP-ase protein kinesin associated with the hydrolysis of ATP and its synthesis. Wherein a transition of the chemical energy into mechanical energy. Each conformational cycle is set a certain number of reactions. Identify the operation and the mechanism of molecular motors which include Ca2 + ATP-ase myosin, DNA polymerase, etc. Establishment mechanisms of nanomotors contributes to finding new methods of diagnostics and treatment.