Prevalence and Resistance pattern of Staphylococcus aureus isolated from a Tertiary Care Centre in Pudhucherry
Authors: Kavitha K, Sowmiya M, Latha R, Venkatechalam GK, Sethumadhavan.
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Objectives: To study the prevalence and resistance pattern of Staphylococcus aureus isolated from abscesses from a tertiary care centre.
Materials and Method: A retrospective study was done at Department of Microbiology, Aarupadai Veedu Medical College and Hospital on 465 isolates from pus samples of which 218 isolates were identified as Staphylococcus aureus upon standard techniques. The samples were obtained from patients with abscess from various sites like foot, legs, hands, surgical sites, skin ulcers, injection wounds of both inpatients and outpatients of all age groups and both gender.
Results: Overall rate of culture positive abscesses were 35.6% (n=465/1306). Staphylococcus aureus is the predominant pathogen isolated contributing to 46.88% (n=218/465) isolates followed by Pseudomonas aeruginosa 15.4% (n=72/465), Escherichia coli 11.1% (n=52/465), Klebsiella spp 6.5% (n=30/465), Proteus spp 5.3% (n=25/465), Enterococcus spp 4.3% (n=20/465), Streptococcus spp2.7% (n=13/465). The highest resistance were observed for Penicillin 98% (n=214/218), followed by Methicillin 79.3% (n=173/218), Clindamycin 73.6% (n=160/218), Streptomycin 72.6% (n=158/218), Amoxyclav 65% (n=142/218), Chloramphenicol 41.8% (n=91/218). Majority of Staphylococcus aureus isolates were sensitive to Vancomycin 97% (n=211/218), Gentamicin 95% (n=207/218), Ciprofloxacin 85% (n=185/218), Erythromycin 78.1% (n=170/218), Oxacilin 52% (n=113/218), Ampicilin 61.3% (n=134/218).
Conclusion: Staphylococcus aureus is the predominant pathogen isolated in our study. Higher rate of isolation were seen among skin ulcers as they are more exposed to environment. Following them were from diabetes patients, since Staphylococcus aureus play vital role in causing varied ulcers because of their lower immunity status. Resistance rates were high for Penicillin, Methicillin, Amoxyclav, Clindamycin and Chloramphenicol because of the abundant use in routine practice. Judicial use of antibiotics, better hygiene and good clinical practices should be followed to prevent the severity of these infections.