The Journal of V. N. Karazin Kharkiv National University. Series «Medicine»

11-14

Authors: O.V. Bilchenko

The aim of the study was to evaluate correlation between diastolic function of left ventricular and autonomic regulation on the base of the heart rate variability indexes at rest and during tilt-test in hypertensive patients. 176 patients with hypertension were included in the study. The data obtained in this study shown that in hypertensive patients diastolic function of left ventricular correlate with autonomic regulation. The decrease of diastolic function associated with low indexes of heart rate variability and unfavorable prognosis concerning mortality in patients with hypertension. During tilt-test compensatory reserve of humoral, sympathetic and parasympathetic brunches was observed in hypertensive patients this decrease of diastolic function.

17-19

Authors: Lie In, A.S. Isaeva, M.I. Yabluchansky

The interrelation between the quality of life and clinical manifestation of arterial hypertension (AH) was studied at 121 patients (out of which were 50 men and 71 women) in the outpatient setting. The age of observed patients was 52.7±8.98 years. The mean continuity of AH is 10.9±8.11 years, the levels of systolic (SBP) and diastolic (DBP) blood pressures are 172.1±16.55 mm hg and 101.9±8.57 mm hg Those who had myocardial infarction less than 5 years ago, heart failure of IV FC, diabetes mellitus, corpulence of the III – IV level, ulcer of stomach and duodenal ulcer were excluded of the research. The group of control was 17 healthy people of the same sex and age. The quality of life was judged by the general index of life quality (GILQ), which was identified by the scale of Ferrans&Power. Three groups of patients with GILQ were picked out, who had 90, from 90 to 120 and more than 120 scores. The calculation of the statistical datum was made due to SPSS 10.0 for Windows. It is shown the definite interrelation between clinic manifestation of AH and patients' quality of life. The more severe clinic cases took place by GILQ with less than 90 scores. The definition of GILQ is recommended for treatment the patients with AH in medical practice.

23-26

Authors: E.M. Babish, V.F. Moskalenco, U.L. Volyansky, U.M. Krasnopolsky, L.G. Verezub, O.B Kolokolova, Z.M. Paramonov, V.S. Didik, V.I. Chueshov, V.I. Belosersky, N.I. Sklar, V.V. Grin

The grund-immunity of sufficient pressure can be created by peroral reusable (9 receptions) the introducings of a pertussoid antigen, protected by zeolite, in doses, in 50 times superior infection doses. The booster - effect was reached at the introducing of smaller doses энтеральных of the forms of antigens (in 2-5 times as contrasted to by doses, which one formation of grund-immunity been cause).

29-32

Authors: U.A. Barshtein

Data post-mortem findings deads of different age for meningo-encephalitis of bacterial, viral-bacterial and viral aetiology have explored. Aetiology of meningo-encephalitis during the life of everybody deads have confirm viral- and bacteriological liquor analysis.

36-38

Authors: D. Velyvyte, A. Laiskonis, A. Gozdzicka-Jozefiak

Infection with high-risk human papillomaviruses (HPV) is a significant risk factor for malignancy. The identification of particular HPV types is important for identifying patients with premalignant lesions who are at risk of progression to malignancy and for epidemiological studies. We present data on the prevalence of HPV infection in the upper respiratory tract of healthy children.

42-46

Authors: E.L. Evstarev

Laimas Borreliosis is a new zoonosis disease with transmissive mechanism of spread of the disease. The basis shows the rate of epidemiological danger causes the rate of infection of Ixodus mites. It is one of the highly met natural-centre diseases on the Crimean territory.

49-52

Authors: V.V. Kononenko, I.G. Vasylyeva, D.Y. Kobytsha

The observation of foreign publications about epidemiological and clinical aspects of polioma-viral infection of human central nervous system, modern methods in its diagnostics and treatment is presented in the research work. First in Ukraine the description of clinical case of recurrence leucocytic-encephalitis, caused by polioma-viruses, with positive result of therapy is made.

56-59

Authors: V.P. Malyi, V.P. Tchulanov, A.T. Podkolzin, T.I. Lyadova, S.B. Lavelin

The data about the frequency of different viral hepatitis B and D genotypes occurrence are shown in the article in the Kharkiv region. The communication of clinical course of the disease is shown due to the identified agent genotype.

62-66

Authors: V.V. Nikonov

It is a lot of problems, bound with a sepsis. In the basis of a pathogenesis of a sepsis the leading role belongs to both exciter, and toxin, developed by him, which one starts the whole stage of pathological processes. The considerable role is allocated to endogenic mediators (cytokines), playing the relevant role in adapting reactings of an organism, at their failure the septic process develops. The reference directions in treatment of this travail are resulted. One of the major moments in treatment of septic process is the antibacterial therapy.

68-72

Authors: N.N. Popov, E.A. Romanova

Mechanisms of humoral and cell-mediated immune responses to viruses were examined in this paper. Mechanisms of IFN-α/β/γ, antibody, cytotoxic T-lymphocytes, NK-cells, macrophages effects were considered. The methods of enhancing immunity to viruses were proposed.

75-78

Authors: А.А. Rudenko, М.М. Gorodeckiy, I.А. Bobrova, Т.N. Pavlikovskay

Data about relapsing malaria are shown in the work. Scheme of treatment stable forms, scheme of prophylaxis malaria are given. Case of giving a late diagnosis of tropical malaria with a lingering relapsing course on a background of sipsis, tertian in female patient with non-Hojkin malignant lymphoma of spleen, and quartan malaria are adduced.

81-83

Authors: N.F. Shystval, V.P. Maliy, А.К. Polykchi, D.E. Ryspaeva, V.М. Dmitrenko

Electrocardiography changes in dynamics in 146 patients with diphtheritic myocarditis have been studied. The most often pathology was: sinus bradycardia for 48,7 %, sinus tachycardia for 32,3 %, atrial extrasystolia for 23,5 %, ventricular extrasystolia for 38,7 %, atrial Bouveret's disease for 9 %, ventricular Bouveret's disease for 5 %, atrioventricular blockage I degree - for 19 %, II degree - for 8,5 %, III degree - for 5,4 %, blockage of a dextral leg of a ventriculonector - for 13,2 %, left-hand leg - for 22,6 %. The blockage of the left-hand leg of a ventriculonector was accompanied by a cardiomegaly with considerable violations of hemodynamics. Electrocardiography investigation is a quite informative method in diagnostic of complications on the part of a cardiac muscle in patients with diphtheria.

86-90

Authors: G.N. Danylenko, A.A. Besedina, S.A. Pashkevich

The aim of the research was to study features of dynamics of physical development in schoolchildren of city ofKharkovwith 1959 till 2002. It is necessary, that the processes of acceleration among children of school century proceed. For the investigated period the growth boys has increased on 6,5 cm, weight of a body - on 3,7 kg; the growth girls - on 4,9 cm, weight of a body - on 1,2 kg. The increase of parameters of physical development occurred not linearly, and with fluctuations, degree of which displays depend on year of research, on age and sex of the schoolchildren.

94-98

Authors: N. M. Korenev, O.O. Khyznyak, T.N. Sulima

The paper presents systematization of complaints of the patients with PPHS as well as the data of their objective examination, confirming the hypothesis of heterogeneity of patients with said diagnosis, and singling out 4 clinical forms of the disease. A systemic analysis has demonstrated that the selected parameters comprise a minimal set of appropriate diagnostic indications for differential diagnosing of PPHS clinical variants. The method of factor analysis used in the study makes it possible to characterize every subgroup. Further studying of pathogenesis of the disease development will allow to apply differential methods in the treatment of the patients.

103-106

Authors: M.I. Lutay, S.I. Deyak, O.M. Lomakovskyi, I.P. Golikova

The 64 patients with stabile angina pectoris with different degree of ingury of coronary arteries by data of coronary ventriculography are investigated. On the basis of parameters of agraggation ability of thrombocites to different inductors, level of Von Willebrand’s factor and fibrinogen there are established interaction between functional condition of thrombocites and hemostaziological function of endothelium. Hemostaziological disfunction of endothelial cell and connected with it disfunction of functional condition of thrombocites cam be defineted as by axpression, so by stage of atherosclerotical processes in coronary arteries in patients with angina pectoris.

112-115

Authors: V. A. Ognev

The data about personality peculiarities of children, suffering from allergic diseases, got with the help of psychological test «SMOL» are cited. It was defined that the preponderance of suspiciousness, dubiousness, diffidence, reticent manner as personality accentuation are typical for such children. Given peculiarities are of great medical and social importance for primary prevention of psychiatric diseases of children.

120-125

Authors: Т.P. Yabluchanskaya, I.P. Vakulenko

There has been studied gender features of heart biomechanics during atrial flutter (research group - AF) in comparison with sinus rhythm (comparing group - SR). The research group consisted of 41 patients with constant AF, 19 females and 22 males, average age was 62±15. The group of comparing consisted of В 29 patients with sinus rhythm, 14 females and 15 males, average age was 65±11. Echocardiographic analysis has been carried out taking into account left ventricle (LV), left atrium (LA) and aorta biomechanic and geomyetry indices in 10 consistant heart cycles. In each heart cycle there has been measured and calculated endsystolic and enddyastolic sizes and volumes of LV, endsystolic and enddyastolic thickness of interventricular septum and LV backwall, LV stroke volume and ejection fraction (EF), LA and aorta linear dimension. Each group of patients has been devided into subgroups according to their gender. The results statistical calculation realized using Exel programme. Acording to all of the indices there has been calculated average (М), maximal (max) and minimal (min), moda (moda) and excess (ex) values. Distinction reliability of indices between groups of patients with AF and SR has been determined using Student method. Obtained gender distinctions in theLVindices more refered to indices absolute values, but not to the distribution law. Similar standard deviations and excess values in the subgroups of comparing patient groups with AF and SR are the reason for the same ultrasound research approach of males and females. In spite of chaotic character of heart biomechanic cycle changes in the subgroups of male and female patients, studied geometric and biomechanical indices, excluding LA dimensions, during AF are corresponding the indices during SR.

10-34

Authors: G. Varoneckas

Heart rate (HR), stroke (SV) and cardiac output (CO) were investigated at individual sleep stages, as well as during active orthostatic test (AOT) at evening before sleep and morning-after sleep in 42 healthy subjects (HSs) and 184 ischemic heart disease patients (IHDpts). HR variability was analyzed using HR power spectrum with calculation of three main frequency components: very low (VLFC), low (LFC) and high frequency component (HFC). There was shown, that constant CO during changes of sleep stages was reached due to increase of SV fol­lowing HR increase during non-REM and by a decrease of SV with increasing HR frequency during REM sleep for HSs. IHD pts demonstrated reduced responses of both HR and hemodynamics, less able to reach constancy of CO during sleep. Decrease of CO was sun at transition from wakefulness to light sleep due to lowering SV and decreasing HR frequency. Decrease of HR was followed by slight increase of SV and CO during sleep non-REM sleep did not enabling to read the level of hemodynamics at wakefulness. During REM sleep there was seen mark­edly diminished CO due to lowered SV, which was not compensated by reduced HR increase. HR power spectrum analysis demonstrated an increase of HFC and decrease of LFC and VLFC during sleep non-REM sleep, pointier to increase of parasympathetic and decreased sympathetic impact to HR control. Marked decrease at of HFC and increase of VLFC, LFC during REM sleep was due to depression of parasympathetic and increase of sympathetic control. Sleep, due to its cyclic activity, was promoting restoration of functional reserve of cardiovascular function, what was rejected by HR decrease and a tendency to increase of SV and CO in HSs. While restoration of cardio­vascular function was going on in HSs mainly due to decrease of HR frequency, e. g. due to increase of parasym­pathetic control, in IHD pts restoration was related more to improving hemodynamics, e. g. due to decreasing pe­ripheral vascular tone, what was sun by means of decrease of total peripheral resistance and systolic blood pres­sure at morning time, as composed to evening.

40-45

Authors: V.A. Mashin

The means of spectral analysis the dependency of Heart Rate Variability (HRV) from the RR-intervals average (RRav, sec) is explored at controlled (forced) breathing. According to got results, the dependency of peaks frequency on spectral density graph for source series of RR-intervals from RRav possible to present the following formula: fp1.0 = fp : RRav, where fp1.0 - peak frequency when RRcp = 1.0 sec, fp - peak frequency at current RRav. For correcting (the standertizations) of frequency domain borders of spectral power (fd) of source series of RR-intervals comparatively current RRav possible to use the formula: fd = fd1.0*RRav, where fd1.0 - frequency domain border at RRav = 1.0 sec. The correction (the standertization) of frequency domain borders of spectral power (fd), frequency peaks (fp1.0) of source series of RR-intervals comparatively current RRav allows to compare different series of RR-intervals without use the transformation to the discrete event series (DES).

50-54

Authors: O.V. Bilchenko

The aim of the study was to estimate types of neirohumoral regulation on the base of the heart rate variability indexes at rest and during tilt-test in hypertensive patients. 176 patients with hypertension were included in the study. The data obtained in this study shown that in hypertensive patients balans of regulatory brunches or increase of humoral regulation observed more frequently. Dominance of neural regulation associated with favorable prognosis concerning mortality in patients with hypertension. During tilt-test decreased brunches at rest increased.

59-80

Authors: D. Zemaityte

The paper represents of the results of analysis of heart rate variability (HRV) in patients with chronic ischemic heart disease (IHD) in the context of search for informative characteristics for prognoses of IHD development and its end-points based on data of 297 healthy subjects and 4561 IHD patients (pts) (range of age was 20-84yr’s). HRV was analyzed by means of calculation of HR power spectrum, HR responses to complex of tests (active orthostatic test, bicycle ergometry, night sleep), non-linear dynamics analysis methodology and baroreflex sensitivity. There was shown, that the pattern of HRV depend on level of development of IHD and its complications or leading pathology, having an impact to HR parameters due changes of mechanism and particular point of influence to HR autonomic control. The level of impact depends of the changes in cardiovascular functional state, particularly of development of congestive heart failure. HRV changes were dependent on increase of an impact of humoral-metabolic HR control due to depression of nervous reflex control, particularly parasympathetic one. Because of that, changes of HRV in IHD pts enable to follow the tendencies of development and treatment efficacy. As it was shown for myocardial infarction, in chronic IHD pts, there were possibility to use HRV characteristics, reflecting parasympathetic control, for cardiac death prognoses.

85-90

Authors: N.I. Yabluchansky, I.I. Zinkovych, I.A. Khripachenko

Comparative analysis of neuro-humoral regulation in the first 20 minutes after isoproterenol injection in extreme doses (6 mg/kg) was done in 2 groups of animals: 11 surviving rabbits and 7 – dead ones. It was shown, that the basic higher total power level of regulation and its more significant rise during the first 5 minutes after isoproterenol injection are typical for dead animals. Opposite, parasympathetic domain reactions of these animals are characterized by decrease of power. Regulation of dead animals is concentrated in humoral domain. Neuro-humoral regulation of surviving animals is normalized to the end of first experiment day.

95-97

Authors: Lie In

The changes of a level TNF-ά and sTNFR in serum of blood for the patients with a chronic heart failure (СН) on a background of therapy are researched. 64 patients with СН II-IV FC are inspected according to NYHA by functional classification. The patients with СН III-IV FC are divided into 2 groups: with a cardiac cachexia (CC) and without СC. Control group - 16 practically healthy people. Before treatment a level of sTNFR1 and sTNFR2 in serum of blood is defined by ELISA method. The observed data allow to utilize the obtained data as a criterion at production of the diagnosis СН and evaluation of efficacy of the treatment. The degree of augmentation of concentration of the investigated factors in serum of blood allows to estimate a degree of manifestation СН, that would entitle the usage of antagonists in the therapy.

102-104

Authors: L.D. Кaliuzhna, M.М. Shmiglo, U.Т. Ibragim, Е.А. Uvarenko

Atopic dermatitis represents as the multifactor generically determined disease of a skin. They determined a general level IgE and allergen specific IgE-antibody to an acaruses of a home dust, investigated association of atopic dermatitis with fungal infection of a skin and its appendages, determined a status of lipid peroxidation in the patients with atopic dermatitis.

112-115

Authors: O.K. Polukchy

77 patients with local forms of diphtheria of oralpharynx and 49 patients with tonsillitis have been examined. Cellular and humoral indices of blood immunity have been studied/ It is established that alterations of immunity in the patients with diphtheria and tonsillitis are of different purposefulness. This fact enables to use these indices for differential diagnosis.

126-134

Authors: E.N. Soloszenko

Modern literature data and investigations results related to the drug disease pathogenesis, diagnostics, treatment and prophylaxis are represented. The discussional matters of the problem related to the terminology, statistics as well as dermatologists and alergologists consensus for curation and rehabilitation of patients with drug disease are described.