International Journal of Ayurveda and Pharmaceutical Chemistry

14

Authors: Sudhir Turi1, Ashish Reja2*, Pawankumar Godatwar3 and Reetu Sharma4

Sthaulya (Obesity) is a disease which invites many other major and minor diseases. It has turned into a pandemic and needs attention from all, for its control. The present study was done to evaluate the efficacy of trial drugs Apamarga Tandula & Vyoshadi Guggulu in comparison to standard drug Sibutramine. Sixty subjects were randomly divided in three groups and Apamarga Tandula was given to group A, Apamarga Tandula & Vyoshadi Guggulu was given to group B and the standard drug Sibutramine was given to group C. Patients having clinical presentation of Sthaulya as mentioned in the ayurvedic texts (Prayatma lakshana) parameters as well as laboratory parameters viz., Hb, TLC, FBS, Cholesterol, TG, HDL, LDL and VLDL, were assessed for its efficacy. The trial groups displayed a comparable result in the laboratory and Prayatma lakshana parameters. In variables such as FBS and LDL, the drug Apamarga Tandula was found to be better than the control drug. In a display of synergistic action, trial drugs Apamarga Tandula + Vyoshadi Guggulu showed the best results in all the parameters, much better than the control drug Sibutramine.

8

Authors: Rashmi Sharma*

The woman is said to be three times more responsible than the male in the procreation. Apart from attending natural processes of menstruation, pregnancy, one of the most inconvenient diseases in woman is Garbhashaya Grivamukhagata Vrana (cervical erosion). Cervical erosion is a common condition seen in almost all women. It affects the whole efficacy of woman which may lead up to infertility. Most commonly used treatment for cervical erosion is cauterization and cryosurgery which have their own side effects like secondary infertility, per vaginal bleeding, stenosis etc. In Ayurveda, Agnikarma has been described in the treatment of Vrana. To evaluate the utility and therapeutic effect of Agnikarma in Garbhashya Grivamukhagata Vrana we made an effort to collect all the available literature mentioned in ancient Ayurvedic classics backed with recent research evidences. Modern science data was collected from various textbooks along with this known database which was available on google, pubmed was selected for present studies from 1994 to 2013.

19

Authors: Gharde Subhash R1* and Inchulkar S R2

In classical Sanskrit literature, Ayurveda was called "the science of eight components" (Sanskrit aṣṭāṅga) a classification that became canonical for Ayurveda. In Ayurvedic literature Upavisa are the group of drugs which were less toxic in nature and not so lethal but produce certain toxic symptoms on consumption or administrations. Our ancient Acharya suggests that the poison can become a very good medicine if it is administered properly. This review is a sincere attempt to summarize the information concerning about semi poisonous drugs described in Indian system of medicine in respect to their literary, pharmacological activity,their toxicological effect, fatal period, fatal dose, treatment, postmortem appearance and medicolegal aspect.

7

Authors: Anamika Shukla*

Pharmacovigilance is awareness towards adverse drug reactions. As per the guidelines of WHO to AYUSH department of Ministry of Health and Family Welfare; Government of India,implemented a pharmacovigilence program for Ayurveda, as a means to ensure the safety and efficacy of Ayurvedic medicines in year 2008. Continuing Medical Education and public meetings are being conducted to raise health professional's awareness of Ayurveda, Siddha and Unani drug. Main focus of pharmacovigilance is on adverse drug reactions (ADRs) and other medication errors to minimize the risk of harm associated with pharmaceutical products. Instead it was not familiar in ayurvedic texts, but the commercialization has brought with it many challenges about safe use of ayurvedic medicines, bringing into focus the need for formal pharmacovigilance programs in the field. Pharmacovigilance system depends entirely on the alertness of physicians towards ADRs. Several challenges that preclude identification and reporting of adverse reactions to ayurvedic drugs can be identified related to detection, assessment and prevention of adverse drug reactions. Awareness should increase about the science of pharmacovigilance among ayurvedic physicians, patients and paramedical staff. Attempt should be pointed towards collecting safety data during marketing of formulation. Safety monitoring of medicines in common use should be an integral part of clinical practice. With the help of modern informatics we can make an effective attempt in this area.

11

Authors: Tawalare Kiran1*, Tawalare Kalpana2, Pawar Jatved3, Sharma Gopal4, Sharma Mrityunjay5 and Ramteke Rachana6

Aging is the process of life that includes progressive physiological and anatomical changes in various systems of body. The proposed study aims to describe various anatomical and physiological changes that occur in old age. Aging process brings about various changes in every system of the body such as cardiovascular, respiratory, gastrointestinal, urinary, nervous, endocrine, reproductive and musculoskeletal. Through the critical analysis of the literature it is found that Ayurveda has given remedies to avoid jara (old age) state of life in the form of rasayan (rejuvenation) drugs, adopting dincharya (daily routine follow up), by avoiding suppression of various adharniya vegas (urges), yogic process and pranayama.