International Journal of Ayurveda and Pharmaceutical Chemistry

8

Authors: Rashmi Sharma*

The woman is said to be three times more responsible than the male in the procreation. Apart from attending natural processes of menstruation, pregnancy, one of the most inconvenient diseases in woman is Garbhashaya Grivamukhagata Vrana (cervical erosion). Cervical erosion is a common condition seen in almost all women. It affects the whole efficacy of woman which may lead up to infertility. Most commonly used treatment for cervical erosion is cauterization and cryosurgery which have their own side effects like secondary infertility, per vaginal bleeding, stenosis etc. In Ayurveda, Agnikarma has been described in the treatment of Vrana. To evaluate the utility and therapeutic effect of Agnikarma in Garbhashya Grivamukhagata Vrana we made an effort to collect all the available literature mentioned in ancient Ayurvedic classics backed with recent research evidences. Modern science data was collected from various textbooks along with this known database which was available on google, pubmed was selected for present studies from 1994 to 2013.

19

Authors: Gharde Subhash R1* and Inchulkar S R2

In classical Sanskrit literature, Ayurveda was called "the science of eight components" (Sanskrit aṣṭāṅga) a classification that became canonical for Ayurveda. In Ayurvedic literature Upavisa are the group of drugs which were less toxic in nature and not so lethal but produce certain toxic symptoms on consumption or administrations. Our ancient Acharya suggests that the poison can become a very good medicine if it is administered properly. This review is a sincere attempt to summarize the information concerning about semi poisonous drugs described in Indian system of medicine in respect to their literary, pharmacological activity,their toxicological effect, fatal period, fatal dose, treatment, postmortem appearance and medicolegal aspect.

7

Authors: Anamika Shukla*

Pharmacovigilance is awareness towards adverse drug reactions. As per the guidelines of WHO to AYUSH department of Ministry of Health and Family Welfare; Government of India,implemented a pharmacovigilence program for Ayurveda, as a means to ensure the safety and efficacy of Ayurvedic medicines in year 2008. Continuing Medical Education and public meetings are being conducted to raise health professional's awareness of Ayurveda, Siddha and Unani drug. Main focus of pharmacovigilance is on adverse drug reactions (ADRs) and other medication errors to minimize the risk of harm associated with pharmaceutical products. Instead it was not familiar in ayurvedic texts, but the commercialization has brought with it many challenges about safe use of ayurvedic medicines, bringing into focus the need for formal pharmacovigilance programs in the field. Pharmacovigilance system depends entirely on the alertness of physicians towards ADRs. Several challenges that preclude identification and reporting of adverse reactions to ayurvedic drugs can be identified related to detection, assessment and prevention of adverse drug reactions. Awareness should increase about the science of pharmacovigilance among ayurvedic physicians, patients and paramedical staff. Attempt should be pointed towards collecting safety data during marketing of formulation. Safety monitoring of medicines in common use should be an integral part of clinical practice. With the help of modern informatics we can make an effective attempt in this area.

11

Authors: Tawalare Kiran1*, Tawalare Kalpana2, Pawar Jatved3, Sharma Gopal4, Sharma Mrityunjay5 and Ramteke Rachana6

Aging is the process of life that includes progressive physiological and anatomical changes in various systems of body. The proposed study aims to describe various anatomical and physiological changes that occur in old age. Aging process brings about various changes in every system of the body such as cardiovascular, respiratory, gastrointestinal, urinary, nervous, endocrine, reproductive and musculoskeletal. Through the critical analysis of the literature it is found that Ayurveda has given remedies to avoid jara (old age) state of life in the form of rasayan (rejuvenation) drugs, adopting dincharya (daily routine follow up), by avoiding suppression of various adharniya vegas (urges), yogic process and pranayama.

16

Authors: Harish Kumar Singhal 1*, Neetu 2, Amit Kataria 3 and Jai SinghaYadav 4

Ashwagandha , commonly known as Withania somnifera (L.) Dunal is an important medicinal plant which is used in indigenous medicine for over 3,000 years. Due to its varied therapeutic potential, it has now become a subject of interest for modern scientific attention. Withania is widely claimed to have potent aphrodisiac, sedative, rejuvenating and life prolonging properties. It is also used as a general energy-enhancing tonic known as Medha Rasayana (‘that which promotes learning and a good memory’) and in geriatric problems. More than thirty five chemical constituents are present in the roots of Withania somnifera. The biologically active chemical constituents are alkaloids and steroidal lactones. To explore this drug and its properties we made an effort to collect literature mentioned in ancient textbook backed with recent research evidences. To achieve this, known database like pubmed, medline were selected for studies from 1988 to 2010. Data obtained in English language from clinical and experimental studies on Withania somnifera were considered. Various clinical & experimental studies proved its utility as anti-anxiety, anti stress, anti-inflammatory, antidepressant, antioxidant, antiageing, anticarcinogenic, antibacterial, adaptogenic, hemopoetic & immodulation activity along with cognition enhancing & memory improving activity with effect on Parkinson disease, neuritic regeneration and synaptic reconstruction.