European Journal of Medicine

Number 10 (1), 2022

3-11
Regulation of Transport of Ca2+ NMDA-Receptors in Rat Brain Synaptosomes Under the Influence of Polyphenols

Authors: Alisher A. Mukhtorov, Rahmatjon R. Mamadaminov, Nozim N. Khoshimov, Kabil E. Nasirov, Rakhmatilla N. Rakhimov, Lutpillaev X Gaybullo

Abstract

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It is known that disturbance of Ca2+ dynamics in nerve cells is universally involved in all pathologies of Alzheimer's disease (AD). It is likely that the use of chemical agents or small molecules specific for Ca2+ channels or membranes of intracellular organelles to correct Ca2+ dysregulation of neurons may open up a new approach to the prevention and treatment of AD. The experiments were carried out according to the Weiler method. Synaptosomes were isolated from the brain of rats by two-stage centrifugation at a temperature of 4°C.To measure the amount of cytosolic Ca2+ synaptosomes were calculated by the Grinkevich equation. The results of the experiments show that there is a possibility of competition between different polyphenols of Caralinia, Granatuum and glutamate for the site of regulation of the opening ion channels оf NMDA-receptors.

12-18
Application of Continuous Glucose Monitoring Systems in Patients With Type 2 Diabetes Mellitus

Authors: Athena Myrou, Theodoros Aslanidis, Triantafyllos Didangelos, Georgia Kaiafa, Andreas Theodoridis, Christos Savopoulos

Abstract

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Number of views: 40

Though continuous glucose monitoring systems (CGMS) have proven their benefits in type 1 diabetes mellitus, research about their use in type 2 diabetes mellitus (Τ2D) are still in progress. The current study aimed to evaluate the use of such systems in patients with T2D in comparison with the standard periodic capillary measurements. Twenty-five patients with T2D under insulin or combination of insulin and oral medication participated in a prospective 7-day observational study. American Diabetes Association 2021 targets for good euglycemic control were used as primary goals for the two groups (CGMS over capillary measurements). Seventy two percent of the participant achieved maintenance of blood glucose within therapy target guidelines. Moreover, 64 % of the participants achieved glycohemoglobin HbA1c < 6.5 %. Glucose values with both methods display high level of correlation ((r = 0.901, p < 0.001) and the same is also valid for HbA1c and estimated HbA1c ((r = 0.939, p < 0.001). Thus, CGMS can achieve both better glycemic control and decrease of HbA1c in patients with T2D. Though the present findings are in accordance with the available literature, further studies in larger populations with more deeper analyses are still needed to confirm the usefulness of CGMS in T2D.

19-23
Reasons Linked with COVID-19 Vaccine Taking and Tentativeness Amid Medical Doctors in ATBUTH Bauchi Nigeria

Authors: Sulaiman Hafizah Sani, Jibrin Yusuf Bara, Maigari Ibrahim Mahmood, Abdulrasheed Hamisu, Umar Yahaya Adamu, Yeboah Kai Kolo

Abstract

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Number of views: 42

Though COVID-19 has been in existence for more than three years, it remains a great public health problem worldwide, causing mortalities, economic and social problems even withing medical doctors. The current study aimed at discerning the main reason why some medical doctors at ATBUTH show reluctance in receiving the vaccine. A cross-sectional study was carried out using questionnaires administered to consenting medical doctors of ATBUTH. A total of 300 were administered, 117 were returned. Random sampling was employed in the selection of participants. Simple Percentages and Means were used to analyze the data. Findings showed 84.11 % of respondents were vaccinated while 15.88 % were not. 19.7 % were fully vaccinated, 57.3 % were partially vaccinated while 17 % were not vaccinated at all. For protection, to avoid travel restrictions, mandatory for work, fear of segregation, others were the reasons for being vaccinated while religious convictions, fear of segregation, conspiracy theories, dearth of information, absence of choice vaccine were the reasons given by respondents for hesitancy to be vaccinated.

24-27
Factors Associated with COVID-19 Vaccine Acceptance and Hesitancy amongst other Health Care Workers besides Doctors in ATBUTH Bauchi

Authors: Sulaiman Hafizah Sani

Abstract

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The acceptance of COVID-19 vaccine and hesitancy among Health care workers besides doctors in ATBUTH was examined with in order to determine the level of COVID-19 vaccine acceptance among health care workers in ATBUTH and to assess the factors of COVID-19 vaccine non-acceptance/hesitancy among health care workers in ATBUTH. A cross-sectional study was carried out using questionnaires administered to health care workers of ATBUTH. Current studies showed that 70 % of respondents were vaccinated while 40 % were not, reasons given by respondents for accepting the vaccine were: 37 % to avoid travel restrictions, 15 % mandatory by employer, 45 % for protection, while 9 % gave other reasons, those that were hesitant in receiving the vaccine did so for fear of side effects, 35 %, lack of adequate information, 30 %, religious belief, 17 %, while 12 % gave a collection of other reasons. Fear of side effects and limited knowledge about the vaccine appear to be the main reasons for vaccine hesitancy among health care workers in ATBUTH.