Journal of Natural Remedis

28-37

Authors: Patil Kalpana and Wadekar Raju

The aim of the present work is to investigate the possible therapeutic potential of Trichosanthes lobata in paracetamol induced hepatic damage in rats. The hepatotoxicity was induced in rats by administration of paracetamol at higher dose (2 gm/kg) reflected in term of increase lipid peroxidation, impairment in antioxidants [Superoxide Dismutase (SOD), Catalase (CAT) and Reduced Glutathione (GSH)] along with elevation of serum marker enzymes. The possible ameliorative effect of Trichosanthes lobata Leaf extracts mainly Aqueous (TLAQ) and Alcoholic (TLAL) were administered at various doses for 7days and found to restored the depleted antioxidants (SOD, GSH, CAT) attenuated lipid peroxidation (MDA formation) and prevented elevated marker enzymes significantly. Further, histopathological alterations were also improved with TLAQ and TLAL in dose dependent manner. Thus, the hepatoprotective activity of TLAQ and TLAL may be correlated with amelioration of oxidative stress by improving endogenous antioxidant defence ability of hepatocytes and histopathological alterations in rats. The ameliorative effect of Trichosanthes lobata in paracetamol-induced hepatic damage in rats was studied.

48-56

Authors: Lamia AlHajri, Moaza AlFalasi, Munira Abdelrahim and Rawdha AlKaabi

Nausea and Vomiting (N/V) are unpalatable manifestations seen commonly during pregnancy, which impinge upon the overall well-being, the productivity and might result in hospitalization. There is growing evidence concerning the efficacy of ginger in alleviating Nausea and Vomiting in Pregnancy (NVP). Therefore, we sought to conduct a systematic review to explore the effectiveness of ginger for NVP. A comprehensive search was conducted in Google Scholar, PubMed, and Science Direct which resulted in identifying five studies. These studies showed that ginger can improve NVP in a statistically significant manner (P< 0.05). Assessing the safety profile of this agent was difficult due to the short duration of intervention, and inconsistency in the dose and dosage form of ginger used. This study helped to glean evidence about the efficacy of ginger in NVP. It also emphasized the need for conducting more studies with a better quality and that are using standardized dose and dosage forms to be able to conduct a meta-analysis.