INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES

1251-1255

Authors: Salma Mirza1 , S.A.Naaz2 , S.M.Alim3 and Azizur Rahman*4

Background and Objectives: Iltehabe Unqur Rehm (cervicitis) refers to the inflammation of the cervix which may be acute or chronic causing various complications. Method: This study is an observational study. All the patients were randomly allocated to test and control group (30 patients in test group & 15 patients in control group). Prevalence of cervicitis is seen among 45 patients according to dietary habits, contraceptive methods and parity. Interpretation and Conclusion: In the present study most of the patient 35(77.80 %) were observed to be vegetarian and non- vegetarian followed by 10 (22.20%) were only vegetarian. Out of 45 patients the highest prevalence of this disease, as observed in the study, was found in women who were tubectomized i.e. 23 ( 51.% ) followed by 18 ( 40 % ) used barrier method and 4 ( 9% ) not using any contraceptives measures. Maximum number of patients included in the study had ≥3 children i.e. 18 ( 40% ) followed by 16 ( 35.60% ) had only 2 children, 9 ( 20 % ) had only one child, and 2 ( 4.40% ) were nulliparous. Key words: Iltehabe Unqur Rehm; Cervicitis; Dietary habits; Contraceptive methods; Parity.

1264-1273

Authors: Dr. M. Purushothaman*1 , V. Viswanath2 , B. Narashimha Rao3 , S. Irshad Begum4

The aim of this study was to Formulation and In-vitro evaluation of liposomal drug delivery system of Decitabine. Decitabine is an anticancer medication is indicated for treatment of patients with myelodysplastic syndrome (MDS). Decitabine Liposomes are prepared by the thin film hydration method using the soya lecithin as the phospholipid. This study mainly explains about the effect of concentration of soya lecithin, cholesterol and Tween 80. The prepared liposomes were characterized by scanning electron microscopic method respectively. The In-vitro release studies were performed and the drug release kinetics was evaluated using linear regression method. The objective of the present study was to develop liposome containing Decitabine and the prepared liposomes were evaluated for size, shape, drug entrapment efficiency, In-vitro drug release and stability. Decetabine loaded liposomes formulation had good ability to encapsulate drug and elicted favorable physicochemical characteristics. The intestinal absorption and antitumor capacity of Decitabine was significantly enhanced by using liposomes. These results suggest that liposomes could be a promising perioral carrier for Decitabine. Key Words: Liposomes, (MLV) multi lamellar vesicles, Thin film hydration method, Decitabine, Lecithin, Cholesterol, Tween 80

1280-1288

Authors: Dr.G.Kiran1* , Dr.K.Lavanya1 , Dr.G.Sireesha1 , Dr. D.M.Ravichand

The socioeconomic and pharmacoepidemological studies have made significant contributions in understanding the risks and benefits associated with current drug therapy. These studies have also been instrumental in addressing various aspects of drug safety and effectiveness that cannot be readily or adequately evaluated using an appropriate experimental design and also the risk and health benefits of the drugs and its outcomes. To understand the scenario the current study was aimed in assessing the health-related quality of life and treatment satisfaction in a large, ambulatory based sample of patients with type 2 diabetes. Attempts were made to investigate the extent of the variables to which they correlate with physical and psychological well-being, and with treatment satisfaction. Thus, it is possible to study clinically relevant outcomes in a timely and cost efficient manner. The results revealed that the type 2 diabetes disease observational studies were correlated with SES measures, which are required in particular during addressing to the biasing effect of disease duration and progression with its severity. Ideally, one should have complete information on hemoglobin A1c (HbA1c), a biomarker for measuring glycemic control which is intern associated with the risk of diabetes and other related complications. Unfortunately, this laboratory parameter is typically unavailable in majorities of administrative health databases developed in rural and urban hospitals and clinics. The primary outcome was loss of glycemic control, defined as a glycated hemoglobin level of at least 8% for 6 months or with sustained metabolism and finally the usage of insulin for combating the disease. In conclusion, the results of the study revealed additional evidence on socioeconomic and pharmacoepidemological parameters and its association with the individuals possessing type 2 diabetes. We also observed that a continuous monitoring of glycaemic control not only forecast the progression of the diseases but also determines the use of medication for healthy leaving. Key words: Pharmacoepidemology, SES, Diabetes, Glycosylated Haemoglobin

1298-1308

Authors: Pooja Gupta*, Gnanarajan and Preeti Kothiyal

The objective of the present study was to formulate and evaluate a gastro retentive in situ gelling system of ciprofloxacin HCl using HPMC K100M, sodium alginate gelling polymer, calcium chloride and calcium carbonate as a cross linking agent for potentially treating gastric ulcer, associated with Helicobacter pylori. The drug delivery systems of in situ forming polymeric formulation is in sol form before administration in the body, but once administered, that under goes gelation in situ to form a gel. The formulation of gel depends up on factor like temperature modulation, pH changes and presence of ions from which drug gets released in sustained and controlled manner. The floating in situ gelling systems were prepared by dissolving various concentration of sodium alginate in deionized water, to which varying concentrations of drug. The results shows that the formulas which containing a combination of the polymers (sodium alginate and HPMC K 100 M) shows more retardation in drug release than formulas based only with sodium alginate at the same percentage. The increasing gas generating agent calcium carbonate reduces floating lag time gelling integrity and increase floating duration. The formulation batch F6 was most suitable preparation being able to control the drug release for longer duration with administration and physiological suitability in terms of pH and viscosity. The in situ gel exhibited the expected, viscosity, drug content, pH, in vitro gelling capacity, in vitro floating ability, water uptake ability and sustained drug release. A stomach specific in situ gel of ciprofloxacin hydrochloride could be prepared using floating mechanism to increase the residence time of the drug in stomach and thereby increase the absorption. Key Words: In situ gel, Gelation, Gastro retentive drug delivery system, H. pylori, Ciprofloxacin HCl.

1314-1322

Authors: Venkata Rao Vutla*, Ramarao Nadendla, K. N. Rajani Kanth

1,5-Dihydrobenzothiazepines Are Synthesized . The Compounds Have Been Screened Foranti Inflammatory And Anticonvulsant Activity. 1, 5-Dihydrobenzothiazepines Are Prepared By The Reaction Of 1,3-Diarylprop-2-Enones With O-Aminothiophenol. All The Products Were Tested For Purity By TLC And Characterized By Elemental Analysis ,IR, 1H-NMR, 13C-NMR And Mass Spectral Studies. Keywords: 2,4-Difluoroacetophenone, 1,5-Dihydrobenzothiazepine, 2-Aminothiophenol, Piperidine.

1332-1338

Authors: Harjot Pal Kaur*, Sukhvir Kaur, Anamika Sharma

The present study was planned to assess the aflatoxins contamination by Aspergillus in grains of maize, rice, wheat and groundnut; some detoxification methods were also studied. From the grains fungus Aspergillus was isolated and identified based on morphological and microscopic features. 3 isolates out of 4 were probably identified as belonging to Aspergillus species and identified isolates were screened for aflatoxins production. Screening for aflatoxins production showed that two isolates, isolated from groundnut and maize, were found to produce aflatoxins as these produced intense yellow orange colour on selective media and blue fluorescent ring under UV light. These two isolates were selected for further analysis of aflatoxins by TLC and ELISA. The results showed that the fungi isolated from groundnut produced more quantity of aflatoxins as compared to fungi isolated from maize i.e. the fungi present in groundnut had greater potential for aflatoxins production. Detoxification of aflatoxins, by chemical (sodium bisulfate) and biological (bacteria B. subtilis) methods revealed that both the methods were effective against this aflatoxigenic fungus. The results of this study showed the contamination of aflatoxins in grain samples and gave further evidence of suitability of screening by microbiological method and detection of aflatoxins by TLC and ELISA, which were reliably low-cost approach to determine food and feed biosafety. Further investigations are required for detoxification of aflatoxins by testing health safe chemicals and biological agents. More and more cost-effective and less time consuming, methods should be developed that can give quantitative results accurately at faster rate. Key words: Aflatoxins, Biological, Mycotoxins, Quantitative, Detoxification