Asian Journal of Chemistry

1815-1823

Authors: Sunardi*, Wiwin Tyas Istikowati, Futoshi Ishiguri and Shinso Yokota

The second generation bioethanol production from lignocellulose materials through environmental friendly methods is one of the biggest challenges on industrial application. Enzymatic hydrolysis of cellulose has more benefits compared with the acid hydrolysis This method has the good specificity, low consumption of energy and chemicals and is more environmental friendly. However, the utilization of lignocellulose for bioethanol production through enzymatic methods is still confronting several difficulties for commercialization. Cellulose hydrolysis step has been reported to be the bottleneck of bioethanol production by enzymatic process, and the major barrier of this process is high price of enzymes, which making the process less economically feasible. For this reason, many developments are still needed in cellulase production from various organisms for cellulose saccharification. White-rot fungi have received much consideration for their valuable enzyme systems which can effective degrade lignocellulose biomass. These fungi could secrete extracellular oxidative and hydrolytic enzymes that degrade lignin, hemicellulose, and cellulose. This review provides a complete overview of the glycoside hydrolases enzymes production by white-rot fungus, such as endoglucanase, exoglucanase, β-glucosidase, cellobiose dehydrogenase and lytic polysaccharide monooxygenase. The use of white-rot fungus for low cost glycoside hydrolases enzymes production might be fascinating for second generation bioethanol production.

1837-1848

Authors: MRINAL SARKAR

2,6-Diformyl-4-methylphenol fluorophore derived Schiff base sensors detect metal ions such as Zn2+, Al3+, Hg2+, Cd2+, Sn2+ and Cu2+ with high sensitivity and selectivity through changes in fluorescence intensity based on CHEF, ICT, FRET, ESIPT, C=N isomerization and PET mechanism. Several anions viz. HPO4 2–, H2PO4 –, PO4 3–, AsO3 3–, H2AsO4 –, AsO2 –, PPi (pyrophosphate), I–, F– and N3 – were also detected through intermolecular hydrogen bonding (between sensor and anion) based on TICT, PET, CHEF, ESIPT and aggregation induced emission mechanism. Selectivity and sensitivity for these metal ions and anions were achieved by introducing various amines to core fluorophore 2,6-diformyl-4-methylphenol. Majority of these fluorescent sensors were Zn2+ ion selective. Due to the filled d10 electronic configuration of Zn2+ ion usually does not show deactivation of excited state via any electron or energy transfer mechanisms. Both solvent dependent and independent ten multi-ion selective sensors are found. This review will consolidate on 2,6-diformyl-4-methylphenol derived Schiff base fluorescent chemosensors.

1857-1864

Authors: G. Krishnaswamy, P. Raghuram Shetty, B. Roopa, Salma Banu, H.J. Preritha, B.S. Rajeshwari, M. Ravikumar, K. Pruthviraj, D.B. Aruna Kumar and S. Sreenivasa*

In the present investigation, we focused our interest on the synthesis of pharmacophoric units (quinoline and 1,2,3-triazole) linked through ester (3a-b) and (substituted aromatic ring and 1,2,3-triazole) linked through an ether (3c-h). The synthesis involves multiple sequence of reactions viz. diazotization reaction followed by nucleophilic substitution and finally Cu(I)-catalyzed alkyne azide cycloaddition reaction (CuAAC). The assigned structures of the compound were confirmed by 1H & 13C NMR and mass spectrometry. Prediction of activity spectra for substances (PASS) training set for the synthesized compounds were carried out using PASS software. Interestingly, PASS prediction of the compounds (3a-h) showed that the compounds are more potent as anti-inflammatory (Pa < 0.65) compared to antibacterial (Pa < 0.33) as well as antifungal agents (Pa < 0.35). Furthermore, these compounds were subjected to in silico ADMETox evaluation. All the compounds were found to pass the ADME evaluation and only few compounds passed the predicted toxicity evaluation. This work could be used as an initial approach in identifying potential novel molecules with promising activity and low toxicity.

1869-1873

Authors: Muhammad Cholid Djunaidi*, Pardoyo and Tri Wahyuni

Desalination of seawater using various polymer inclusion membranes was carried out. Polymer inclusion membrane (PIM) is known to have the highest stability, able to overcome liquid membrane instability and was placed in between two phases: the source phase is seawater and the receiving phase is the micro-filtered water. Determination of salinity levels in the feed phase and the receiving phase was carried out using a salinity meter, while membrane characterization was done using FTIR and SEM techniques. Polyvinyl chloride (PVC) based PIM membranes were prepared using different single and mixed synergtic carriers ratio of 1:1 viz. dibutyl ether, methyl-trioctylammonium chloride (Aliquat 336), di-(2-ethylhexyl)-phosphate (D2EHPA), thenoyl trifluoroacetone (HTTA), tributyl phosphate (TBP) and eugenol (PE). The results showed the salinity value for single HTTA carriers had a greater salinity value in comparison to mixed carriers (HTTA:TBP; HTTA:Aliquat; D2EHPA:TBP; and D2EHPA:Aliquat) gave different salinity value towards the desalination process.

1881-1885

Authors: Sathiyanarayanan Singaram*, Venkatesan Chidambaram Subramanian, Senthamaraikannan Kabilan and Dandu Bhaskara Suresh Raju

Fosphenytoin sodium is a water dissolvable phenytoin prodrug that is directed intravenously to convey phenytoin, conceivably more securely than intravenous phenytoin. It is most ordinarily utilized in the intense treatment of convulsive status epileptics. The examination of the procedure-related contaminants will not help exclusively to advance the process parameters yet additionally to create sensible analytical methods and set the quality standard for a quality control system in pharmaceutical manufacturing. During the production of fosphenytoin sodium, all the process-related impurities are controlled in every stage and three degradation impurities are managed in the final API as per USP monograph. Besides, five unknown and one known contaminants were detected by HPLC method. All these impurities were identified, synthesized, isolated and characterized by IR, 1D-NMR (1H, 13C, DEPT) and HRMS spectral techniques. The mechanism of the formed impurities is examined for the first time. Quality control procedures to manage these impurities were developed to acquire the mass medication of ICH grade quality.

1895-1902

Authors: Manisha R. Sawant*, Suresh T. Gaikwad, Bhaskar H. Zaware and Anjali S. Rajbhoj

Present work involves the synthesis of substituted dimethyl octahydroquinazolinones by using electrochemically prepared copper oxide nanoparticles as catalyst in microwave. Copper oxide nanoparticles were prepared in appreciable yield by using electrochemical reduction method of synthesis in the presence of tetrabutylphosphonium bromide for capping. The prepared nanoparticles were analyzed by UV, FTIR, TGA, X-ray diffraction and electron microscopic studies. The nanoparticles of copper oxide then were successfully used as a catalyst in multicomponent reaction between diketones, substituted aldehydes and urea/thiourea to synthesize substituted dimethyl octahydroquinazolinones.

1909-1919

Authors: Thippeswamy Basavaraja and Giriyapura R.Vijayakumar*

An octahedral Ni(II) complex viz. diisothiocyanatobis(dmbpy)nickel(II) (3) based on 4,4′-dimethyl-2,2′- bipyridine (dmbpy) ligand was prepared by conventional method under mild reaction conditions. Besides analyzing FT-IR spectrum and the determination of percentages of atoms of elements, a thorough investigation of thermal and photophysical properties of the present complex was carried out. Diffuse reflectance spectrum of the complex scanned in the range 200-1100 nm displayed a prominent peak at 455 nm, with exhibiting reflectance percentage of 45. The measured band gap energy of the complex obtained by following Kubelka-Munk (K-M) function was found to be 2.18 eV. The photoluminescence spectra that incorporated excitation and emission spectra exposed the likely possibility of emission of blue light by the complex, for which the Commission Internationale de l’Eclairage (CIE) coordinates of (0.3009, 0.2942) were calculated. A fairly high thermal stability of the synthesized complex with the incorporation of thiocyanate ligands, practically confirmed by simultaneous TG-DTA measurements, could be explored for application as an emissive layer in the fabrication of OLED devices.

1921-1924

Authors: T.M. Ahamed Hussain and B.N. Sivasankar*

Anionic complexes, pyridine-2,6-dicarboxylato uranylate containing protonated weak bases such as hydrazine, guanyl hydrazine and pyridine as charge neutralizing entities have been isolated from aqueous solution containing respective bases, dipicolinic acid and uranyl nitrate hexahydrate. The molecular compositions and structural geometries have been assigned by analyzing their elemental analyses, spectral data and thermal patterns and the molecular formulae, A2[UO2(PDC)2] where A= N2H5 +/ AGH+ (aminoguanidinium) or PYH+ (pyridinium) cation and PDC = pyridine-2,6-dicarboxylate dianion has been proposed for the newly synthesized coordination compounds. Oxidative degradation in air yielded U3O8 as the residue, which has been proposed on the basis of thermogravimetric weight loss and powder XRD pattern. Based on the spectral results and careful analyses, a hexagonal bipyramidal geometry has been assigned for all the three uranyl(II) complexes.

1931-1940

Authors: Sailu Betala*, Hanumandlu Racha and Chiranjeevi Abba

Novel triazolothione, thiadiazole, triazole and oxadiazole-tagged trifluoromethyl group containing naphthyridine derivatives (6a-l and 7a-d) were synthesized from 2-amino-6-(thiophen-2-yl)-4- (trifluoromethyl)nicotinonitrile (1) on treatment with acetophenone and obtained 2-phenyl-7-(thiophen- 2-yl)-5-(trifluoromethyl)-1,8-naphthyridin-4-amine (2), compound 2 on reaction with bromoethylacetate and after that reaction with hydrazine hydrate and obtained carbohydrazide derivatives (4), compound 4 on reaction with different substituted phenyl isothiocyanates to obtain phenyl hydrazine carbothiamide derivatives (5). Compound 5 is independently reaction with NaOH, H2SO4 and N2H4·H2O to obtain triazolothione, thiadiazole, triazole-substituted naphthyridine derivatives (6a-l), respectively. The carbohydrazide compounds 4 on reaction with diverse substituted aromatic acids and obtained oxadiazole derivatives (7a-d). All the synthesized compounds (6a-l and 7a-d) were tested for anticancer activity against four cancer cell lines such as “HeLa-cervical cancer (CCL-2) COLO 205-colon cancer (CCL-222) HepG2-liver cancer (HB-8065) MCF7-breast cancer (HTB-22) and one normal cell line (HEK 293)”. Compounds 6b, 6d and 6l are known to have good anticancer activity at micro molar concentration and found to be non-toxic on normal cell line. And all the products 6a-o and 7a-d were tested against Gram-positive, Gram-negative bacteria and fungal strains. All the compounds, compounds 6e-h showed more activity against Bacillus subtilis (MTCC-121) at < 6.8 micromolar concentration. Compounds (which showed more activity) further screened for minimum bactericidal concentration against B. subtilis MTCC 121 using ciprofloxacin as standard and known to show optimistic activity. These compounds further tested for biofilm inhibition activity against B. subtilis MTCC 121 using erythromycin as standard which confirmed the high activity.

1947-1954

Authors: J. Ramesh Babu*, K. Ravindhranath and K. Vijaya Kumar

The effect of doping nano Sm2O3 particles in PVA + Na3C6H5O7 (90:10% w/w) polymer composite films on the structural, thermal, electrical properties and battery parameters are investigated. The PVA + Na3C6H5O7 + nano Sm2O3 (90:10:1- 4% w/w) films were synthesized and characterized. A 2% w/w Sm2O3 film was relatively homogeneous with high amorphous in nature enabled the movement of nanoparticles in the matrix of polymer under potential gradient. The maximum conductivity was 2.09 × 10-3 S cm-1 for 2% w/w nano Sm2O3 film and it is 7 orders more than polyvinyl alcohol. The films were adopted in batteries with configuration: Anode (Mg+MgSO4)/[{PVA:Na3C6H5O7 (90:10% w/w)} + nano Sm2O3 (1-4% w/w)]/cathode (iodine + carbon + pieces of electrolyte) and battery parameters were assessed. The discharge time is 174 h with the cell having 2.0% w/w nano Sm2O3 film. These nano Sm2O3 doped films are successfully adopted in the fabrication of batteries and also the proposed cells are simple, effective, eco-friendly and economical.

1961-1966

Authors: Ahmad Husain, Mohd Urooj Shariq*, Sharique Ahmad1, Anees Ahmad and Faiz Mohammad

Herein, the synthesis and characterization of a novel polypyrrole (PPy)/zinc oxide (ZnO)/SWCNT nanocomposite together with pristine polypyrrole is reported. These as-prepared materials have been characterized by FT-IR spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and thermogravimetric analysis (TGA) techniques. The PPy/ ZnO/SWCNT nanocomposite is used as a pellet-shaped ammonia sensor. The sensing response is calculated in terms of variation in the DC electrical conductivity at different concentration of ammonia ranging from 50 ppm to 2000 ppm. The sensing response of the sensor is determined at 2000, 1000, 500, 400, 300, 200, 100 and 50 ppm and found to be 76.3, 60.5, 54.8, 52.6, 50.2, 48.5, 40.5 and 36.6%, respectively The sensor displays excellent reversibility along with very high selectivity and stability. Finally, a sensing mechanism is also proposed involving polarons (charge carriers) of polypyrrole and lone pairs of electrons of ammonia molecules.

1972-1980

Authors: Anas R. Al Johani, Saud M. Almutairi, Wael S. El-Sayed, Pramod K. Sahu, Praveen K. Sahu and Mouslim Messali

A series of sixteen new ionic liquids (ILs) bearing imidazolium moiety were designed and synthesized under sustainable and green conditions which were confirmed by analytical and spectral techniques using 1H- & 13C-NMR, FT-IR, mass and elemental analysis. A panel of clinically isolated strains was used for in vitro inhibitory antimicrobial activities screening of synthesized ionic liquids. The results of antimicrobial assay showed that some of synthesized ionic liquids showed moderate to good activity. Among these ILs, ionic liquids 3, 4 and 5 (bearing alkyl chain with a phenyl group) significantly inhibited cell growth of strains. In this regard, these ionic liquids considered as promising antibacterial agents when compared with standard antibiotics. By encouraging in vitro antimicrobial screening, in silico ADMET evaluation has been performed and found excellent pharmacokinetic, bioavailability and toxicity profiles. Synthesized ionic liquids has found to be safe and non-toxic according to calculated in vivo computed LD50 values (2.49-2.80 mg/kg) for rat acute toxicity.

1986-1990

Authors: Ayusman Swain and Hariprasad Puttaswamy*

The present study investigated the phytochemical constituents from Canna indica rhizome acetone extract, which was earlier reported to possess α-glucosidase inhibiting potential. Different fractions were collected from column chromatography of the acetone extract and the in vitro enzyme inhibition and the kinetic study was performed with the active fraction. The active fraction exhibited competitive inhibition of α-glucosidase. HRLC-MS/MS technique was used to identify the lead compounds from the active fraction. The major compounds were psoromic acid, usnic acid and rosmarinic acid. Molecular docking study of the compounds with the crystal structure of α-glucosidase was performed using ParDOCK. Psoromic acid and usnic acid exhibited strong binding affinity with the active site nucleophiles Asp349 and Asp212, respectively. Usnic acid also stabilized the catalytic residue Glu274. Rosmarinic acid formed multiple hydrogen bonds with the catalytic residue Glu274 and also bonded to non-catalytic residues Gln276, Arg312 and Glu408. The study illustrated informative data on the phytochemical constituents from Canna indica rhizome as α-glucosidase inhibitor and as potential candidates for the development of antidiabetic drugs.

1996-2000

Authors: V. Mohanraj, S. Ponnuswamy*, P. Muthuraja and M. Dhandapani

Growth of a new organic single crystal of N-acetyl-2,6-bis(4-methoxyphenyl)piperidin-4-one (APM3EPO) is reported by using a slow evaporation method. The characterization of the crystal was done by IR and NMR spectra. Further, electronic spectrum and TG/DTA studies have also been carried out. The SHG efficiency of the crystal was found to be closer to that of standard KDP (potassium dihydrogen orthophosphate) using the modified Kurtz-Perry powder test employing Nd: YAG laser as the source of IR radiation. The calculated hyperpolarizability values were also projected to confirm the aptness of the crystal for non-linear optical applications. Optimization of the molecular structure of APM3EPO is done at the basic level of B3LYP/6-311(d,p) and the corresponding molecular properties such as HOMO-LOMO and Mulliken charge analyses are carried out at the same level of theory.

2007-2012

Authors: Mahendra B. Bodake, Ghanshyam R. Jadhav, Vijay J. Medhane and Avinash D. Bholay

A series of new molecules containing pyrrolidine and thiazole moiety (4a-l) were designed and synthesized. The structures of the synthesized compounds were characterized by IR, 1H NMR and mass spectral data. All the synthesized compounds were screened for their antibacterial activity against strains of bacteria as well as antifungal activity against fungal strains. Minimum inhibitory concentrations (MICs) of all the synthesized compounds were determined. The screening of title compounds revealed that most of the tested compounds showed moderate to good microbial inhibitions.

2021-2027

Authors: A.S. Aswar* and K.A. Thakare

The metal complexes of Ti(III), Cr(III), Fe(III), VO(IV), MoO2(VI), WO2(VI), Th(IV) have been synthesized with hydrazone ligand. The mononucleating hydrazone ligand has been synthesized via condensation reaction between pyrazine-2-carbohydrazide and 2,4-dihydroxy benzophenone in 1:1 ratio. The ligand and its complexes were studied on the basis of elemental analysis, magnetic susceptibility measurements, IR and electronic spectra, TGA, XRD, 1H NMR, mass spectroscopy and SEM analysis. Spectroscopic and magnetic studies suggest coordination of most of the metal complexes in a regular octahedral around the central metal ions except vanadium which is square pyramidal. Free ligand as well as its metal complexes were screened against the growth of pathogenic bacteria. The inhibition data revealed that metal complexes exhibit higher inhibition potential against growth of bacteria and fungi than free ligand.

2033-2037

Authors: Abdelfatah A. Fadlelmula*, Abdulaziz Y. Al-Ghamdi and Mohamed O.M. Abdalla

In this study, the active ingredients from Coleus forskohlii were detected and evaluated their antioxidant and antimicrobial activities. Coleus forskohlii leaves were collected, air dried, powdered and extracted first with aqueous ethanol and secondly with petroleum ether, chloroform, ethyl acetate and n-butanol successively. The chemical analysis of the extracts showed the existence of (flavonoids, alkaloids, tannins, terpenoids, steroids, saponins and sugars). Furthermore, the extracts were subjected to analysis of total phenolic contents. Where the n-butanol exhibited highest TPC value (384.23±15.86 mg GAE/g), followed by ethyl acetate (199.73±29.35 mg GAE/g) then petroleum ether (96.97±61.29 mg GAE/g), ethanol (90.80±17.51 mg GAE/g), and eventually chloroform extract exhibited the lowest (TPC) value. In addition to that the antioxidant status of the different extracts of Coleus forskohlii was detected. Butanolic extract showed the highest radical scavenging (96.33±1.53 %, lowest IC50 value 0.03) followed by ethyl acetate extract (46.67±3.50 %, IC50 value 0.07). Eventually the antimicrobial activity tests were carried out for all the plant extracts. Where n-butanol showed the maximum inhibition (14±0.70 mm). All the pathogens except C. albicans exhibited moderate response towards petroleum ether extract. C. albicans was sensitive towards ethanol extract only (14.00±1.41), whereas the other Gram-positive and Gram-negative bacteria exhibited high impedance to the ethanol, chloroform, and ethyl acetate extracts. This study scientifically props the usage of whole plant as a medicine for several surface bacterial and fungal strike in folk medicine, in addition to this the plant may serve as a exporter for additional development of indigenous antioxidant and antitumor agents.

2043-2050

Authors: Phattarasuda Manantapong, Nattanon Chaipunya, Suttipong Wannapaiboon, Prae Chirawatkul, Worawat Wattanathana and Yuranan Hanlumyuang*

The inhibiting action of Thai-bael fruit extract at room temperature on hot-rolled steel in 1M HCl solution was studied. The chemical functional groups of the green inhibitors were characterized by Fourier-transformed infrared spectroscopy. The electrochemical activities of steel surface were investigated through linear polarization measurements, electrochemical impedance spectroscopy, surface assessment techniques based on optical microscopy and X-ray absorption spectroscopy. Electrochemical testing samples have been prepared in the form of square plates with the size 1 × 1 cm2. The organic corrosion inhibitor extract from Thai-bael fruit has shown the smallest corrosion current density (Icorr) of 114.8 μA cm-2 and corrosion potential (Ecorr) of -424.6 mV, compared with standard Ag/AgCl electrode potential. In comparison, similar tests in the bare HCl solutions yielded Icorr = 882.4 mA cm-2 and Ecorr = -445.8 mV. The mixed-type corrosion inhibiting behaviour was evidenced in the results of the polarization measurements. Electrochemical impedance spectroscopy reveals that the resistance to charge transfer due to the presence of the extracts has been increased by about four times that of the same test on the bare HCl solution, indicating the formation of a protective layer. The adsorption of the organic molecules near the steel-electrolyte interface is evident in the decreasing double-layer capacitance with the enhancing concentration levels of the extract. This latter finding supports the displacement of the water molecules by means of the adsorption of the inhibitors on the steel surface. The optical images of steel surface before and after being immersed in HCl solution also showed pieces of evidence of corrosion retardation. XANES study as well as the linear combination fitting revealed that the samples immersed in HCl solutions with Thai-bael fruit extract possess less Fe3+ compositions. All tendencies across the four examinations indicate that Thai-bael fruit extract could potentially inhibit the corrosion reaction of steel electrodes in the acidic solution.

2055-2060

Authors: S.J. Hepziba Magie Jessima*, B.G. Rakesh, Moksha Muthappa and S. Subhashini

Lime, a vibrant fruit of citrus family is known for its antioxidant as well as anti-microbial properties. The constituents of lime juice include organic acids, polyphenols, soluble sugars, vitamins, minerals and amino acids. These details prompted to experiment lime juice as corrosion inhibitor for mild steel in 1 M HCl. The weight loss studies showed that the corrosion inhibition efficiency increased with increase in concentration of the lime juice as well as increase of temperature. The inhibition efficiency reached a maximum of 96% for an immersion period of 24 h. The best fit for the adsorption process obeyed Langmuir isotherm. The negative value of ΔGads showed the spontaneity of the corrosion inhibition process. The corrosion inhibition efficiency of the acidified lime juice was further validated by electrochemical studies namely AC impedance studies and potentiodynamic polarization studies. The surface morphology study was performed used optical profilometer.

2067-2074

Authors: J. Puvithra and D. Parthiban*

Diversely functionalized chromeno-pyrimidine-2,5-dione/thione compounds were synthesized by cyclocondensation of 4-hydroxy coumarin, aldehydes and urea/thiourea using tannic acid as a green catalyst and 1:1 (EtOH:H2O) as a green solvent. Different acids were screened for their catalytic activity of chromeno-pyrimidine-2,5-dione/thione derivatives. Tannic acid (10 mol%) was used as a suitable catalyst with increased catalytic activity. By utilizing this protocol, chromeno-pyrimidine scaffolds were prepared in acceptable to excellent yield without the use of conventional volatile organic solvent and toxic metal catalyst. To our best of knowledge, this is the first report, in which tannic acid is utilized successfully as an eco-safe catalyst for synthesis of fused pyrimidines.

2079-2083

Authors: Paweena Porrawatkul, Rungnapa Pimsen, Saksit Chanthai and Prawit Nuengmatcha*

In this study, silver nanoparticles (AgNPs) were successfully synthesized from aqueous Terminalia catappa leaf extract that acts as a novel reducing agent. Various parameters, including pH, temperature and reaction time, were determined. The UV-visible spectra showed the main peak at 416 nm, which was the characteristic surface plasmon resonance of AgNPs. The spherical shape and particle size of 49 ± 0.01 nm were observed from SEM, TEM and laser particle size analysis (LPSA). FTIR spectra of the leaf extract exhibited the characteristic functional groups that should be responsible for Ag+ ion reduction. The EDX spectrum proved that the obtained sample is silver. The antioxidant activity of AgNPs treated with the leaf extract as determined by the DPPH assay was higher compared to that of Terminalia catappa leaf extract, and the treated AgNP sample exhibited high antibacterial potential against both Gram-positive and Gram-negative bacteria.

2091-2098

Authors: Md. Hasibul Islam*, Md. Chanmiya Sheikh, Ryuta Miyatake, Ronok Zahan and Md. Al-Amin-Al-Azadul Islam

The bis-chelated four coordinate complexes (ML2, L = deprotonated ligand) of Zn(II) and Pd(II) ions were synthesized, derived from a new bidentate NS Schiff base called S-benzyl-β-N-(4-hydroxy-3- nitrophenyl)methylene dithiocarbazate (HL) which is the condensation product of S-benzyl dithiocarbazate (SBDTC) with 4-hydroxy-3-nitrobenzaldehyde. The synthesized ligand and complexes were characterized using conventional techniques like NMR, UV-visible, IR, mass spectroscopic techniques, magnetic susceptibility measurement and molar conductance. A single crystal X-ray crystallography data approved the proposed crystal structure of the ligand. Both in solid and solution phase, the ligand continues to exist in its thione tautomeric form. The chelates were formed by the reaction of ligand with the metal ions through the ligand azomethine nitrogen atom and the deprotonated thiolate sulfur anion. Magnetic susceptibility and electronic spectroscopic data suggested to have a tetrahedral geometry for ZnL2 complex whereas a square planar structure for PdL2 complex. The analgesic and anti-inflammatory bioactivity were assayed on both the ligand and its complexes by tail flick and carrageenan induced paw edema test. The ligand at the dose of 10 mg/kg, produced a significant (***p < 0.001) increase in pain threshold in tail flick methods when compared to control but in case of complexes, it showed moderate activity. At the same dose, the ligand and complexes significantly (***p < 0.001) reduced paw edema when compared to the control. Altogether, these results suggest that ligand and its complexes could be used as a potent anti-inflammatory agent.