Health Risk Analysis

14-17

Authors: Khamidulina Kh.Kh.

The analysis performed of modern trends in chemicals handling and implementation in the RF and abroad showed the understanding that the chemical factor poses an integral hazard to human health and the environment and requires significant conjoint efforts to regulate it as well as the necessity to harmonize domestic regulatory and methodological bases with international requirements; to implement GLP and GHS into the hygiene and preventive toxicology practice ; to create and implement a national program in systemic investigations into substances publicly traded on the market in order to withdraw those posing a high risk from circulation and replace them by safer alternatives.

30-41

Authors: Deynego V.N. , Kaptsov V.A., Soroka A.I.

It is shown that in a pineal gland serotonin-melatonin synthesis process from tryptophan is classified as oscillatory process. This process can be described in terms of pattern that allows building seasonal and annual schedules of melatonin doses changes in blood. Redistribution between serotonin and melatonin in the hormonal spectrum is regulated by light exposure time on ganglion cells of eye retina, and the levels of melatonin doses depend on the sensory characteristics of the pineal gland. Cyclical process of melatonin synthesis under the influence of light can enter into dissonance with astronomical cycle of the pineal gland, which disturbs the harmony in the antioxidant system of an individual and affects his/her health, increasing the risk of disease in distance future. Morphological studies of the pineal gland showed that in it a variety of crystals (calcite, fluorite) are synthesize, which can be combined into three-dimensional matrices. These crystals have direct and inverse piezoelectric effect, and may contain ions of phosphorus, magnesium and fluorine. Studies have shown that the concentration of fluoride in the pineal gland of an individual is more than in his/her bones. The analysis of calcite (CaCO3) formation in various biological systems has been implemented and the new model of interaction between crystals and intracellular structure of the pineal gland has been proposed. In this system model there are interlinked crystals of calcite, which touch the glial cells, with the grid in which there are canals with melatonin, which form in the human brain an area sensitive to grade-gravitational effects (from redistribution of surrounding mass or changes in specific ambient density). Suggestions to correct hygienic requirements to the light spectrum and lightning time from the artificial sources have been formulated. Requirements for excluding fluorine introduction into food stuff (milk, flour, water) and into hygienic items (tooth paste) also have been formed. Melanopsin pattern can be accepted as a basis for forecasting techniques for detection of melatonin levels in the antioxidant system of an individual.

48-54

Authors: Novikova T.A., Raykin S.S., Buyanov E.S., Spirin A.V. , Rakhimov R.B. c

The complex physiological-hygienic evaluation of the working conditions of agricultural machine operators in the dynamics of the annual production cycle of growing crops is carried out. It is set that the machine operators performing basic types of work are subject to the combined effect of harmful factors of environment and labour process, the levels of which correspond by the degree of deviation from the hygienic standards to harmful labor conditions of 1–4 degrees (classes 3.1–3.4). Levels of blood pressure, hemodynamic and functional status (IFS) show tension of regulator systems and reducing of the body's adaptive capabilities of the machine operators that can be caused by exposure to adverse working conditions.

68-75

Authors: Kamaltdinov M.R.

As a part of multi-level model of accumulation of functional disorders in the human body under the influence of environmental factors, the sub-model of “meso-level” of digestive system is being developed. The article highlights the tasks of reconstruction of 3D model of antroduodenal area of the gastrointestinal tract and evaluation of nodes dislocation of the computational grid at the passing of peristaltic wave in gastric antrum and pyloric sphincter motor activity. The observed approaches could be applied in health risk assessment at peroral exposure to chemicals.

83-89

Authors: Lebedeva-Nesevrya N.A.

The article describes the necessity of interpretation of the risk-communication in the field of public health as a method of information provision between concerned parties who are equal participants of the dialogue. The article offers the values and the health risk levels as well as their decreasing methods. The key parties of riskcommunication are: a) expert community; b) decision-makers; c) population; d) mass media; and e) non-profitmaking organizations.

97-103

Authors: Luzhetsky K.P., Ustinova O.Yu., Maklakova O.A., Palagina L.N.

The study of incidence of endocrine diseases in children, living in conditions of high level risk of inhalation exposure to chemical technogenic factors of large industrial center, has been performed. In the condition of high level risk of chronic aerogenic exposure to benzene, phenol, benzo (a) pyrene the violations of thyroid homeostasis, carbohydrate and fat metabolism (goiter (E04.9), the excess food (E67.8) and obesity (E66.0)) were diagnosed in 1.3-2.0 times more likely than in the comparison group. The relationship of the formation of endocrine disorders in children with increased content of benzene, phenol and benzo (a) pyrene in blood has been established. Children, living in the areas with chemical atmospheric pollution with substances influencing hormonogenesis and light iodine deficit, have a reduced level of iodine provision, changes in the structure and volume of the thyroid gland 1.7-2.4 times higher than in the comparison group.