International Journal of Ayurveda and Pharmaceutical Chemistry

5

Authors: Malvika Badyal, Veenu Malhotra

Khalitya is a dermatological disorder characterized by gradual hairfall. It is a Tridoshaja Vyadhi dominated by Vatta-Pitta. In Khalitya, hairfall is primarily caused by aggravated pitta dosha along with vata dosha at the root of hair follicle; while at the same time, kapha dosha with rakta dosha blocks the roots of hair follicles. Most Ayurvedic manuscripts have described hair disorders under Kshudra Roga with names like Khalitya, Palitya, Indralupta, Darunaka etc. However, it has been mentioned as Tridoshaja Vikara in Sutrasthana while Vagbhatta has mentioned it under Shiroroga2 . This is a case study of 48-year-old female complaining of hair fall along with itching on scalp who visited the OPD of Kayachikitsa at BKAMCH, Moga. As per protocol, this case was treated in the line of Khalitya. In present study, Shiroabhyanga is advised with Bhringrajadi oil.

5

Authors: Khushali D Zalavadiya, Ruchika A Chaudhary2 and Vandana Raval3

According to Ayurveda science the musculoskeletal and neurological disorders are mentioned under the general term Vatavyadhi. Sandhigatavata is one of the diseases of Vatavyadhi. When the VataDosha gets vitiated & accumulated in various Sandhi Sthana and that causes impairment in normal function of Sandhi,soit is called Sandhigatavata. In that Janusandhigata Vata is the most commonly seen.The condition similar to Sandhigata Vata has been described as Osteoarthritis in modern science. Osteoarthritis is the chronic degenerative joint disease, which commonly affects the knee joint which leads to difficulty in walking, movement restriction or painful movement. A 53-year-old female patient was diagnosed with Sandhigatavata since 6 month. Patient was treated with the help of general Vatavyadhi chikitsa along with direction of Pathyapathya. After 3 months treatment, symptoms were significantly reduced. Patient had marked improvement after 3 months complete course of treatment plan. The detailed case study will be described in full paper.

5

Authors: Harmeet Kour

Bhallataka is one among the wonderful drugs used to cure many diseases like inflammation, piles, cancer etc in Indian system of medicine. Shodhana is must before administering the drug to the patients. The oily fraction in the pericarp of the fruit is responsible for the toxic nature of the drug. To purify Bhallataka fruit ishtika churna method is followed.

7

Authors: Aboli S Girme, Rahul S Suryavanshi

As mentioned by Acharya Charaka that Oil is the best remedy for Vatika disorders. In the oil, most preferable oil is Sesame oil as given by AacharyaCharaka in Sutra sthana. The continuous use of Sesame oil alleviates Vata, as oil is unctuous (Snigdha), hot (Ushana), and heavy (Guru) while Vata being dry (Ruksha), cold (Sheeta) and light (Laghu) is of the opposite nature. Sesame oil Abhyangais the best remedy to protect once from the disorders caused due to imbalanced Vatadosha. Here we will know about the importance of Sesame oil Abhyanga as a preventative measure in Vatavyadhi. As prevention is always better than cure as Ayurveda always focuses on maintaining health though natural practices.

8

Authors: Kirti Mishra, S R Inchulkar2 and Yuvraj Kaushik

Ayurveda is an ancient science having description of the topical applications in the name of Lomashatan Lepa which is known as hair removal formulation described to enhance the beauty. Objective- To document various hair removal formulations (Lomashatan lepa) described in Ayurved and make them available for the research workers to revalidate their efficacy. Methodology- Collection of data related to various herbomineral hair removal formulation such as Hartal, Manahshilla, Palash kshar, Shankh bhasma, Sarjika kshar etc. from Ayurvedic classical text books. Discussion-Almost all depilatory formulations documented in the Ayurvedic literature use for the purpose of topical applications only. On a critical study it is observed that Hartal, Manahshila, Sarjakshar, Sankha Bhasma, Palash kshar are present as the main ingredient in different lomshatan Yogas. Most of these drugs are Katu Rasa; Sukshma, Tikshna, Laghu Guna; Ushna Virya and Katu Vipaka and are having Lekhana and Kesaghna property. Conclusion-Research work of Hartaladi Yoga, Kusumbha Taila has been done in different institute to understand the efficacy of lomashatan or hair removing action which concludes that they are nontoxic and efficacious. Hence the other formulations can also be tried by conducting pre-clinical and clinical trials and make them available for the benefit of a large number of suffering population so as to provide safe and cost effective solution.

9

Authors: Prerana Dixit, Govind Sahay Shukla2 , Rajaram Agarwal3 , Manisha Goyal4 and Vijaypal Tyagi5

Rasashastra forms the basis of Ayurvedic pharmaceutics and the principles of dhatuvada, dehavada, and chikitsavada forms the basis of Rasashastra. Rasendra Chintamani is one among the textbooks that explains these principles. The current article focuses on the book's structure, author, historical period, chapters with detailed information, and unique features. Rasendra Chintamani holds an important place amongst academicians, researchers and student of rasashashtra. The contribution of the text towards Ayurveda is also described in details. The uniqueness of Rasendra Chintamani is in the description of several metallic and mercurial preparations for the purposeof internal use as medications.

10

Authors: Renu, Soni Kapil2 and Anil Bhardwaj

Woman - a marvelous creation of almighty goes through variable stages during her reproductive life. The alterations in her body during puberty, reproductive, menopausal and postmenopausal stages, create affinity towards different diseases. Menarche and Menopause are the landmarks of reproductive stage of woman's life. Though, Rajonivritti as a diseased condition is not described separately in classical Ayurveda text. In Ayurveda Menopause deals with the JaraPakwaAwastha of body1 .Menopause is generally defined as cessation of periods for 12 months or a period equivalent to three previous cycles or as time of cessation of ovarian function resulting in permanent amenorrhea2 . The Menopause is thus a gradual and natural transitional phase of adjustment between the active and inactive ovarian function and occupies several years of a women's life and involves biological and psychological adjustments. This period is usually associated with unavoidable manifestation of aging process in women. Quality of life covers physical, functional, emotional, social and cognitive variables. Menopause is a natural event as a part of the normal process of aging, it is turning into a major health problem in recent years in developed as well as developing countries. HRT(Hormonal replacement therapy)is effective treatment for menopausal syndrome but not safe and with dangerous side effects like endometrial hyperplasia, CA etc. Thus; we can make a safe approach through Ayurveda to minimize these perimenopausal symptoms. 2Aim & Objective: The present study is an effort to understand the disease according to Ayurvedic principles& to evaluate the role of safer and cost effective Ayurvedic management modalities in perimenopausal symptoms. Materials &Methods: Patient with age 49 years with 2 years of menopauseaccompanied by symptoms of excessive sweating and sleep disturbanceduring night. The probable cause found after routine examinations and history taking was perimenopausal changes in patient. She was visiting the OPD of PTSR Department for this complaint andsirodhara and basti were advised in treatment. Results: Patient got relieved after the panchkarama procedure i.e; sirodhara, basti. Conclusion: Hence; it has been concluded that Panchkarmacan be practiced as palliative management for perimenopausal symptoms by Ayurvedic gynecologists with promising outcome.

11

Authors: Pravesh Tomar, Sudipkumarlal

The functions of female reproductive system as well as its sufferings are comprehensive and should always be concerned withrhythm of whole-body, mind and soul. The endocrine system of female body takes roller coaster ride starting from puberty to end at menopause. Diet, life style and if needful medicinal support plays a very important role for stabilizing this rhythm. Any disorder in dietary habits and life style would ensue or evolve tridosaprakopa (abnormality in vata, pitta and kapha).Only those disorders are left for divine help which are not expressing clear interrelation among hetu (aetiology), ling (sign and symptoms) andsamprapti(pathophysiology) and lead to an intricate task to decide the upshaya(therapeutic effects) and chikitsa(treatment) of any particular disorder. Pushpaghni Jataharini which now be compared with PCOD/PCOS may be understood as divine wrath. In both cases the aetiology and pathophysiology are still not very clear. Scholars have emphasised on environmental factors (e.g., diet. nutrition, socioeconomic status and geography) whichcan exacerbate the pathology of PCOS even in cases of genetic origin of PCOS; on the other hand, toxicants evolve from infectious agents and autoimmunity may also play a role. Thus, the cause of polycystic ovarian syndrome is unknown, but studies suggest thata strong genetic component that is either affected by gestational environment, lifestyle factors or both. The age of prevalence of PCOS is 15-40 years i.e., from puberty to reproductive phase of woman.

16

Authors: Kundan Rameshwar Meshram, Tushar Sheshrao Dhawali

Hriday is one of the important marma among Trimaramas, which may leads to fatal consequences even on the slight injury. There is not any direct reference of Aushadhijanyahridroga in our ancient textsbut our ancient Acharyas explained the cardiac disturbances as the side effect of medicines which are not prepared properly. This shows that they were well known about the drug induced cardiotoxicity. In Agadtantra, Garavisha is explained as a one of unique concept which artificially prepared by the mixture of various substances responsible for various disorders. Itis the vast aspect mentioned in our ancient literature, which can be compared with various sources of exposure of toxins through our daily life activities in which we can include various drugs and chemicals used in modern medical science are also produced toxic effects like Paracetamol, aspirin, erythromycin, oral contraceptives etc. Such a way Cardiotoxicity occurs due to many chemotherapeutic agents and other drugs can also be understood under the concept of Garavisha. The aim of this article is to review contemporary aspect of cardiotoxicity induced by drugs and classical aspect of Garavisha. It is an attempt to find correlation between them. This will be helpful in exploring the different treatment modalities associated with of drug induced cardiotoxicity.