International Journal of Ayurveda and Pharmaceutical Chemistry

4

Authors: Preeti, Neerja R. Sharma

Amalpitta is commonest complaint or condition visible in current scenario, which is resultant of faulty lifestyle and eating habits followed by individuals. A single case study with follow up was done to see the effect of VamanDhauti along with lifestyle modification in control of Amalpitta, because of dynamism of health it is mandatory to be in mode of maintenance of health.

4

Authors: Ozal Patel, Harshit S Shah2 , Rajesh Kumar Sharma3 , Priti Engineer4 and Saurabh Patel

Background: Among commonly occurring traumatic skeletal injuries sprains and strains are more prone. These injuries appear to be simple, but are more painful and hamper the routine activities. A sprain is an injury to a ligament- a stretching or a tearing. Ankle is the most common site for acute musculoskeletal injuries and sprains. In all such conditions initial complaint of patients will be pain associated with swelling with or without deformity. Sometimes it has been chronic due to improper treatment. Acharya Sushruta- the ancient Hindu surgeon has described about the management of traumatic joint injuries and stated about the application of manjishthadi lepa in such type of injuries in his book Sushruta samhita. This attempt aims at exploring the scope of ayurveda in management of different type of musculoskeletal injuries, the effect of manjishthadi lepa in ankle sprain will fulfill our treatment aim.

5

Authors: Madhavi Rakhamaji Shelke, Lata Ambadas Rathod

Ayurveda is divided into 8 branches, among this Shalakyatantra is one of the most important branch had describe the importance of eye, without which a life is miserable.“Sarvedriyaanam Nayanam Pradhaanam”. Eye is the most precious organ in the body. So, it is the prime duty of every person to take care of his eyes. Now a days, due to busy life style people don’t have time to think and act for the healthy life and unable to follow proper Sadvrutta palan, dietetic rules and regulations. It may be responsible for etiopathogenesis of visual disorders. In such situations normal functioning of eyes can be maintained optimum with proper diet and therapies like Yoga, Pranayama and Trataka. It can be helpful to prevent multiple eye diseases. Yoga, Meditation and Diet Contributes much important role in Netraswasthya and also to cure various eye diseases allied with drug therapy. Trataka is one of the shatkarmas which is very powerful and useful to attain mental and physical balance. Trataka is one of the useful yogic Purification in Netraswasthya.

6

Authors: Nikita Gupta, Rajesh Kumar Malviya2 , Atal Singh Kushwaha3 and Abha Khare4

The exponential boom in industrialization and human civilization has led to progress but also has been enduring enormous life style disorders such as cardiovascular diseases, stroke, metabolic disorders, pulmonary disorders, musculoskeletal disorders ,cancer etc. due to their unhealthy lifestyle and if this unhealthy lifestyle and food habits are not intervened on time can lead to these life threatening diseases or even death .In Ayurveda treatise moreover in Charak Samhita Acharya Charak has mentioned Swastha Chatushka that comprises the ideal way of healthy living ,and that is the need of today’s era to follow various measures cited in Charak Samhita so as to attain health and longevity.

6

Authors: Ashwini Kumar Kushwaha

Leucorrhoea is condition where excessive amount of white discharge occur from vagina due to inflammation or infections of lower genital tract and one of the most common symptom of gynaecological morbidity. In Ayurveda leucorrhoea is considered as Shweta pradar, where sweta means ‘white’ and pradar means ‘discharge’ and usually occur due to vitiated Kapha and Rasa Dhatu. Depending on the involvement of dosha the discharge can be thin watery, slimy, sticky, purulent, curdy white to frothy with foul smell. It may be physiological but when turn in to pathological condition, produce symptom like itching in vulva, backache etc. Treatment of leucorrhoea depends upon the causative factor, prakriti of patient’s, involvement of Doshas etc. Usually leucorrhoea is a curable disease, but recurrence is a common due to causative factors. Many classical preparation and medicinal plants are described for the management of leucorrhoea in ayurvedic classics. Efficacy of such ayurvedic drugs are discussed in present paper.

6

Authors: Surendra Kumar, Gopesh Mangal2 and Shashi Prakash Gupta

Neonate care is of huge importance for the appropriate growth and for baby's healthy life. Neonatal health is single among most of the significant health challenges facing the developing world. After birth, the baby depends on external help and needs to adapt to live outside the womb and to develop a sense of security in the newborn, Abhyanga is essential. Abhyanga which is daily oil massage is a routine practice in the care of neonates for their growth and development. In Ayurveda, Abhyanga is advised right from birth to make the child conscious and stable.

6

Authors: Ashwini Kumar Kushwaha

Nowadays the complexities of human life, indulging in fast means of living, changing lifestyle, eating habits and increasing mental pressure in the race to become so-called cultured and civilized are the root causes of many diseases. A result of this changing lifestyle is a disease called "Amalpitta" and the number of such patients is increasing day by day. Eating food without hunger and eating against the season reduces the digestive fire and this leads to improper digestion of food. Improperly digested food, when mixed with bile, produces burning sensation, thirst, diseases of the mouth and ‘acidity’.Acharya Sushruta has considered the taste of Prakrit pitta (bile) to be bitter and the taste of distorted or vidagdha piita (bile) as acid. When there is an increase in Vidgdha Pitta, it is called Amlapitta. ‘Amal-vidagdham cha tat pittam amlapittam’. In modern science it is known as hyperacidity and it is becoming a rapidly growing dreadful disease of stomach. Generally, two out of every five people are suffering from this disease. In present paper important aspect of Amlapitta (hyperacidity) and efficacy of medicinal herbs in its management are discussed.

7

Authors: Pathak Reetika, Inchulkar S R² and Bhagat Sangeeta

No person is immortal in the world, and no one can stop death. Ayurvedahas a unique place in terms of health and well-being, the importance of Ayurveda for peace in life has increased even more due to the modern lifestyle and side effects of our Karma (deed). The main purpose and objectives of Ayurveda is the preservation of health in healthy individual and eradication of diseases, which are curable. Diseases that manifest in a locality by the same source i.e. due to vitiation of land, water, air etc. are called Janapadodhwamsa. Inspite of consuming different food, habit, age, constitution person gets affected by one and the same disease due to abnormal water, air etc. these abnormalities are due to abnormal movement of planets, calamities, which occur naturally in the earth, atmosphere and the sky. The cause of epidemics is effect of sinful acts of people who are residing in the epidemic prone area. The common factors which affect mass population are Vayu (air), Udaka (water), Desha (land), and Kala (season). There are three tenets describes in Ayurveda to proposed a healthy and patient related subject. Knowledge of pathogenesis, symptomatology and therapeutics is best way for both healthy and the sick. In Ayurveda, ‘Code of conduct’ is described as an Aachar Rasayana, and Dincharya, (Daily routine) Ritucharya (seasonal regimen) by following this; people and nations are entitled to the achievement of disease free long life.

7

Authors: Seema Yadav, Hardik Chudasama2 and Aparna Sharma

Abstract – Introduction- Ayurveda is a science of life which gives more important on maintaining health of healthy individuals and to cure the diseases of the patients. To fulfil this purpose Ayurveda emphasis on many basic principles like Dinacharya (Diurnal regime), Ritucharya (Seasonal regime) and AcharRasayana (Modal code of conduct). The prevalence of Shiro, Nasa,Karna and Mukha roga has shown consistently an upward trend through the last few decades. Materials and Methods- Review from diverse Ayurvedic literatures, research journals, magazines and authentic internet sources. Discussion- Review suggests that Tilataila, kanji (gruel), Yusha, Cow milk and Ghee, nimbu, amalaki etc... are beneficial in Shiro roga, Luke warm water, meat of wild animals, Yusha, the substance which have pungent in taste are beneficial in Nasaroga, Shalidhanya, mudaga, yava, patola, punarnava, Karvellak etc... are beneficial in Karnaroga and Mudaga, Kultha, Karvellak, Paravala, Kapitha, Shatawari and Khadira etc... are beneficial in Mukha roga. Conclusion – Pathya is the one which keeps the person healthy and maintain normal function which leads to proper functioning of the organ, nourish the mind and intelligence, prevents disease and at the same time corrects the irregularities that may occur in the body. Thus everyone should abstain from Apathya and follow Pathya as prevention is better than cure.

8

Authors: Mishra Prasun Prannay, Asthana Alok Kumar2 and Asthana Monika

Coronavirus disease-2019 (COVID-19) is a global public health emergency and has affected every country in the world. It was announced as a Public Health Emergency of International Concern by the end of January 2020 and a pandemic in March 2020. With the public health challenges, this pandemic has created another parallel pandemic of mental health problems. It also exaggerated the existing mental health problem .There would be deterioration of mental health of front line workers as well as general public. Due to lockdown effect and increase in covid patients disastrously there would be vast increase in frightening of getting infected, feeling of fear of getting quarantined, fear of loss of profession, fear of losing jobs, fear of poverty, fear of hunger etc. Due to various psychological impact of covid19 on individuals there is increased tendencies of suicidal attempt. Here in this descriptive study the efforts are being made to put together the different perspectives of Ayurveda which can be implemented in the management of different psychological conditions. With concepts like Sadvrutta,AcharaRasyana, Adharma, PrajnnaparadhaAyurveda proved to be beneficial for management of psychological impact of Covid 19 on individuals.

8

Authors: Suchithra K, Shrikanth P H2 , Arhanth Kumar A3 , and Sudhakar Bhat

BACKGROUND: Sandhaniya Mahakashaya Varga is one among the Panchashanmahakashaya explained in Charaka Samhita, Sutra Sthana 4 th Chapter. Chakrapanihas commented that Sandhaniyameans Samgrahana(withholding) in general (that is explained under Atisara). This indicates that there are certain other meanings too for the word Sandhaniya. Few are healing (as in case ofVrana Sandhana) and few areStambhana (as in case of stopping Raktapravrutti). This paves a way to explore the wider actions of the drugs mentioned under Sandhaniya Gana as Stambhana along with Vranasandhana effect which is the need of the hour. As there are different meanings for the word Sandhana, an effort was made to see the VranaropanaandStambhanaaction of Guduchi, one drug among the Sandhaniya Gana. AIM: To assess the Vrana Sandhana and Rakta Stambhanaaction of Guduchion excision wound. METHODOLOGY: An experimental study was carried out to assess haemostatic and wound healing activity of Guduchiby using excision wound model technique and bleeding induced experienmt in Wistar Albino rats by taking wound contraction, histopathological study of wound tissue and bleeding time, clotting time as parameters respectively. RESULT & INTERPRETATION: Observations after the study showed that there was non significant increase in the percentage of wound contraction in test group which shows the wound healing enhancing property of the drug Guduchi and histopathological study also supported the same. Guduchi showed statistically significant result with respect to reduction in bleeding time. There was statistically nonsignificant reduction in the clotting time. CONCLUSION: The results of the study revealed that the test drug Guduchi has both wound healing enhancing property as well as haemostatic property. Thus it can be concluded that the word Sandhana means Vrana Sandhana in case of wound healing and it means Rakta Stambhana in case of Raktatipravrutti.

8

Authors: Chithra K, Sheethal Dinesh Lende

BACKGROUND: Prameha is one among the Ashtamahagada Vyadhi. If, Prameha is neglected and proper therapy is not given, then it can lead to the manifestation of Prameha Pidaka. The Prameha Pidakas or the Upadravas of Prameha can be co-related with the complications of Diabetes. The foot complications in Diabetes are the most frequently seen complication in Diabetes. Early recognition and management of independent risk factors for ulcers and amputations can prevent or delay the onset of adverse outcomes. As explained in the SwasthaChathushka, the care of the foot is highlighted in Dinacharya context.Health Education can help to extend knowledge and to strenghten desired behaviour patterns. So here the study was conducted as a health education in the form of a Self Instructional Module in order to increase the awareness of foot care among the Prameha patients. OBJECTIVES:To assess the knowledge of foot care before and after implementation of Self Instructional Module among Prameha patients. METHODOLOGY: An Interventional study was conducted after selecting 100 subjects from the hospital as per inclusion and diagnostic criteria, by the set of questionnaires regarding the Knowledge of Diabetic foot and Diabetic foot care and then the assessment of knowledge before and after implementation of Self Instructional Module was carried out. The results obtained from the above parameters were statistically analyzed and conclusion were drawn. RESULTS: The overall knowledge regarding Diabetic foot among Prameha patients was 18.23% in pre-test and 99.15% in post-test. The overall knowledge regarding Diabetic foot care among Prameha patients was 56.43% in pre-test and 89.43% in post-test. CONCLUSION: The study concluded that the Self Instructional Module was effective in improving the knowledge regarding Diabetic Foot and Diabetic Foot care among Prameha patients.

8

Authors: Hem Parkash

Cervical erosion is a common gynaecological problem, which can be caused by congenital,due to hormonal changes, taking contraceptive pills and due to pregnancy. Cervical erosion can be correlated as Karnini Yonivyapad due to its clinical features described in ayurvedic literature.Vitiated dosas is the leading cause of yoni roga. Karnini yonivyapda is a vataja, kaphaja and rakhtajyoni roga caused by akala prvahan (straining without labor pain) during prasava (labor) and produce karnika (protuberance or papilla) in yoni. This case is ideal example of cervical erosion or Karnini Yonivyapad and is successfully treated with ayurvedic drugs. Patient was suffering from foul smell-whitish discharge with backache and weakness since 2 to 3 years. She had taken allopathic treatment but was not relieved completely. Now her problems aggravated since 4 month with left side abdominal pain and burning sensation around the umbilical region. On P/S examination cervical erosion was present over both cervical lips with thick white discharges. P/V examination showed AV uterus, fornices clear and tenderness present. PAP smear was done to exclude CIN (cervical intraepithelial neoplasias) and it was found to be normal. Considering the clinical features the patient wastreated with Cap Leukoline 2 BD, Tab Amlapittantak Yog 1TDS, Cap Sery 1BD, Pushyanug churn-3gm with Tunkan Bhasma 250 mg/1×2BD and Syp Amlapitamishran 1TSF TDS. For yoni prakshalana or douching Panchwalkal Kwath used with local application of Tunkan kshar application over cervical erosion, than apply Neembu swarasa over that place. The above treatment continued for 3 months with 3 follow up in every month. Yoni prakshalan or douching and tunkan kshar application done only for 7 days in every month after clearance of menses. In every follow up patient clinically improved. In last visit patient on P/S examination showed complete cure of cervical erosion with symptoms resolved.

8

Authors: M Midhunasree, Ramadevi G 2 and Arpana Jain

A woman is treasured by the richness of continuing the human race. Pregnancy is the most important and critical part of everywoman’s life. Wide range of references regarding garbhini paricharya,masanumasika pathya, garbhopaghatakara bhavas,soothika paricharya are available in brihatrayi and laghutrayi. To ensure normal pregnancy and uncomplicated labour, with delivery of a healthy baby from a healthy mother our Acharyas have explained a detailed and systematic month wise regimen and a list of do’s and don’ts to be followed in the antenatal period which ismainly dependent on maintenance of kapha. This article emphasizes on the role of kapha in garbha vrddhi.

9

Authors: Priyanka Bhatt, Sunil Thakur2 , Vijay Chaudhary3 and Manik Soni

Shwasa Roga is one of the common and deadliest diseases according to Ayurvedic literature and similarly according to modern medical science, Chronic Obstructive Pulmonary Disease (COPD) is a common respiratory disease having high morbidity and mortality, whose symptomatology resembles to Shwasa Roga. It affects all socioeconomic groups equally all over the world and its prevalence is increasing day by day. Morbidity and mortality of the disease is also rising with the passing years. It not only affects respiratory system but other systemic components also get involved with its progression. There is no absolute cure for this disease but to reduce its morbidity, mortality and fatal complications patient requires long term therapy. So, a controlled clinical study was planned to develop a safe and cost-effective therapy to manage this chronic disease. Haritakyadi Gutika(Chakradatta Kasachikitsa 11/30)and Vasadi Kwatha (Yogratnakara Shwasa Nidana 5)werethe interventional drugs used in this study whose ingredients were mainly Tridoshashamaka and work on Pranavaha Srotasa. Study was done on thirty subjects diagnosed with COPD, aged between 45-75 years. Studysubjects were screened from OPD and IPD of Kayachikitsa department of Rajiv Gandhi Govt. Post Graduate Ayurvedic College and Hospital Paprola and were diagnosed on the basis of spirometric results. Spirometry was the main tool for inclusion of subjects in this study. Registered subjects were treated for thirty days with above mentioned drugs in group I and tablet Doxofylline in group II. Statistically significant improvement was observed after the completion of therapy in some of the symptoms. Haritakyadi Gutika in the dose of 2 gram per day and Vasadi Kwatha in the dose of 100 ml per day found to be more effective in cough and expectoration as compared to tablet Doxofylline in the dose of 400 mg per day. On overall assessment therapeutic effect of Haritakyadi Gutika and Vasadi Kwatha was found to be comparable to the standard drug i.e., tablet Doxofylline. As per the safety concern no untoward effect of drugs seen during the entire trial period.

9

Authors: KhushbuTT, Sheethal Dinesh Lende

BACKGROUND: Pama Kushta is one among the Kshudra Kushta, caused by vitiation of Pitta and Kapha Doshas. Based on the signs and symptoms, Pama Kushta can be correlated to Scabies in modern science. It is an intensely pruritic skin infestation caused by the mite Sarcoptes scabiei var hominis. Skin related epidemics are the causes of 14% of all contagious diseases in India. Among all contagious skin diseases Scabies accounts for 28%. Scabies can cause secondary infections and other complications including severe systemic illness if it is left untreated. Lack of awareness regarding the contagious nature of the disease as well as poor educational background contributes towards the prevalence of Scabies. A video assisted teaching programme is a planned teaching material of lecture combined with video which is imparted to the study group includes the concept in detail. The study has aimed at creating an awareness regarding Pama Kushta (Scabies) among the parents of children suffering from the disease and providing knowledge regarding Primary as well as Secondary prevention in order to prevent the occurrence of disease in vulnerable category and to prevent the complications in diagnosed cases respectively. OBJECTIVES OF THE STUDY 1. To assess the knowledge of parents regarding the prevention of Pama Kushta (Scabies) in children by a pre test. 2. To assess the effectiveness of video assisted teaching programme on prevention of Pama Kushta (Scabies) in children among Parents by comparing the pre test and post test knowledge. METHODOLOGY: A video assisted teaching programme was conducted after selecting 100 parents of children who were suffering from Pama Kushta (Scabies) and the knowledge regarding the disease as well as its prevention were analysed by using a structured pre-test and post-test questionnaire before and after the programme. The results were analysed by using descriptive statistical test and conclusion were drawn. RESULTS: The overall knowledge regarding Pama Kushta (Scabies) among parents of children suffering from the disease got increased from 26.7% to 84.9% after the video assisted teaching programme. CONCLUSION: The video assisted teaching programme was successfully imparted to the study group, helped to increase the knowledge level regarding Pama Kushta (scabies) and its preventive aspects.

10

Authors: Rupali Praveen Kamble, A P Vaijwade

These days due to dust pollution and unhygienic conditions, Hyperaemia of Conjunctiva occurs, and it has become commonest most frequently occurring eye disease. It is a custom to treat the patient of Hyperaemia of Conjunctiva with Decongestant and Lubricating eye drops. Though such medications give symptomatic relief in short time period but recurrence is not prohibited as it does not act on root causes so it has been decided to solve out the problem by an Ayurvedic line of treatment.

11

Authors: Roshni K P

Kala is unique and specific causative factor of all type of effects, which is unavoidable. It is described as a Nimitta Karana, (instrumental cause) which means no action is possible without the causative association of Kala. That is why, Ayurveda being science of life, gives emphasis on the concept of Kala. The relationship between Bhesaja and Kala is having great applicability in the management of diseases. As per Acharya Vagbhata, Kala explains the administration of Bhesaja1 . Similarly, Acharya Charakaalso pointed out that Bhesaja given at proper Kala is more effective than the one which given at inappropriate Kala.

12

Authors: Azara Qureshi, Sunil Thakur2 , Vijay Chaudhary3 , Anjana Mishra4 and Manik Soni

Background:The incidence of Kamala is very common due to erratic lifestyle, food habits and sanitation (water pollution and contaminated food). On the basis of similarity in clinical symptomatology, Kamala can be co-related with jaundice as described in modern medical science. It is not an independent disease entity but a clinical condition which may arise due to diverse disease conditions. Multifactorial etiological conditions can result in impairment of liver function which clinically manifests as jaundice. Hence, apart from treating the basic disease which is responsible for this condition, every effort has to be done to improve the liver function which is primarily deranged.Objectives: To evaluate the effect of Eladi Churna and Draksha Ghrita in Kamala Roga. Methodology:A comparative clinical study was conducted on thirty patients of Kamala. Patients fulfilling the inclusion criteria were randomly selected for the trial and put into two groups of 15 patients each. Group-I was treated with Eladi Churna while group II was treated with Eladi Churna and Draksha Ghrita. Sign and symptoms of Kamala asNetra, Twaka, Nakha, Mukha and Mutra Peetata, Avipaka, Aruchi, Hrullasa, Chardi, Daha, Daurbalya, Angasada, Kandu as well as biochemical assessment was done as total serum bilirubin, serum glutamic oxaloacetic transaminases, serum glutamic pyruvic transaminases were recorded before and after treatment. Patients of obstructive jaundice, jaundice due to carcinoma of liver, gall bladder, pancreas, acute hepatocellular failure were excluded from the study. Assessment suggests improvement in patients suffering from Impaired Liver Function after 3 weeks of treatment.Results: Both Groups showed statistically significant result in terms of subjective as well as objective criteria. Group-II treated with Eladi Churna and Draksha Ghritashowed better result compared with Group-I treated with Eladi Churna.

12

Authors: Pooja Badani, Hitesh Vyas

Among all dreadful conditions arising because of modern day living, Diabetes is a giant disease considered as one of the arch enemy of the mankind caused by improper diet and lifestyle. It is often referred to as a „Silent Killer‟. Diabetes and its complications pose a major threat to public health resources throughout the world. So it is like to understand how Prameha is arising as preventive aspect of Ayurved. Also holistic approach of Ayurveda in regard to preventive, promotive and curative measures with due consideration of appropriate diet & lifestyle to provide better health by preventing Samprapti. Taking these facts in focus, trying to elaborate all the aspect of Samprapti of Prameha.

15

Authors: Sithara M S, Joy Verghese T2 , Hariprasad P3 andMigy John

Background: KatakakhadirādiKaṣāyaṃis a classical Ayurvedic Polyherbal preparation used for the treatment of diabetes, skin, and urinary tract ailments. However, to scientifically validate its efficacy and also to develop it as a product fulfilling all domestic and international regulatory guidelines, preclinical in vivo safety and efficacy data is essential. Objectives: To assess the toxic potential of, KatakakhadirādiKaṣāyaṃ,when administered orally in repeated doses to Wistar rats. Methods: KatakakhadirādiKaṣāyaṃwas manufactured at CARe Keralam Ltd. Subchronictoxicity study of KatakakhadirādiKaṣāyaṃ, with 28 day reversal period, was conducted in six groups of rats with equal number of males and females. On completion of treatment and recovery periods, blood and tissue samples were collected from rats, from respective groups, for evaluation. Results: Hematological and serum biochemical analysis data did not show any statistically significant differences in KatakakhadirādiKaṣāyaṃtreated groups compared to respective normal control groups. On necropsy, no gross pathological changes were noted in the treated animals compared to the control animals. Histopathological examination of internal organ samples from the control and the treatment groups did not reveal any pathologically significant changes. Conclusions: From the results of this study, the No-Observed-Adverse-Effect–Level (NOAEL) of KatakakhadirādiKaṣāyaṃ in Wistar rats, after administration for 90 days was found to be 2300 mg/kg.