Journal of Current Medical Research and Opinion

Number 01, 2019

66-71
Anti-Inflammation Potentials of Ageratum Conyzoides against Crude Oil-Induced Inflammation and Sperm DNA Damage in Male Wistar Rats

Authors: Ita, S. O. , Francis, E. E. , Eda, A. U. , Abia, E. R.

Abstract

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Sperm carry the necessary genome materials require for procreation in the deoxyribonucleic acid (DNA), and the integrity of this DNA is cardinal to the survival and function of spermatozoa. This integrity can be compromised due to the vulnerability of sperm cell which could impact negatively on male reproductive health. Forty male Wistar rats (119-128g body weight) were divided into eight groups of five rats each. Group I served as the control and were oral gavaged 3ml/kg of normal saline; groups II-IV gavaged 374.17mg/kg, 748.33mg/kg and 1122.50mg/kg body weight of the extract of Ageratum conyzoides respectively. Group V was gavaged 3ml/kg body weight of Nigerian Bonnylight crude oil (NBLCO). Groups VI-VIII was co-administered the aforementioned doses of the extract of Ageratum conyzoides with 3ml/kg body weight of NBLCO respectively. The results showed that NBLCO significantly increased DNA damages, elevated C-reactive protein and interleukin-6 levels compared to the control and extract of Ageratum conyzoides groups (p<0.05). The co-administration of ethanol leaf-extracts of Ageratum conyzoides with NBLCO significantly reversed these trends (p<0.05). While the NBLCO significantly decreased platelet count and percentage of the circulating neutrophils compared to the control and extract treated groups (p<0.05), it significantly elevated the total white blood cell count (p<0.05). But the co-administration of the extract with NBLCO significantly increased platelet count as well as the percentage of circulating neutrophils (p<0.05). It is concluded that the co-administration of ethanol leaf-extract of Ageratum conyzoides with NBLCO can ameliorate sperm DNA.

72-75
Role of Education of Diabetes to Controlling Plasma Glucose, BMI, Cholesterol, Blood Pressure in Central Hospital Nampula

Authors: Dr Madhumati Varma MD

Abstract

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Number of views: 226

Mozambique is located on the East Coast of Africa. In this country, obesity, poor knowledge regarding diabetes, and a lack of awareness of the complications of diabetes are prevalent. Furthermore, most of the population utilizes traditional healers for the treatment of diabetes. There are unhealthy food habits, a sedentary lifestyle in the urban population, and increased economic growth among office-related professions, which is one of the risk factors that cause diabetes and its complications. Currently, no study has been conducted for patients on the effects of education in various modalities of diabetes. Accordingly, there is an extreme need to educate diabetic patients to improve their control of diabetes and to reduce its complications. Adequate medical management and proper lifestyle measures should start directly at the time of the diagnosis of diabetes, which can result in the diabetic individual living a life just as cheerful as that of a non-diabetic person. However, this objective requires proper counselling of the patient specifically at the time of diagnosis, which can be achieved by well-planned educational programs that target the newly diagnosed diabetic individual and create awareness about diabetes. In central hospital Nampula in diabetic OPD, three education sessions were organized, at an interval of one month (baseline, first follow up and second follow up). Each participant was evaluated in each session regarding their BMI, blood pressure, plasma glucose, cholesterol concentrations. The statistical analysis showed strong significantly positive correlation effects with glucose to BMI, blood pressure, cholesterol on controlling each of these parameters. Prior to the commencement of the baseline education session, an evaluation of the evolution of patient knowledge regarding diabetes mellitus (the pretest) was performed. At the end of the second follow up, a posttest was performed, which showed strong significant increases in the knowledge of diabetes.

76-79
Specific Chemotherapy Treatments for Patients with Ovarian Endodermal Sinus Tumors

Authors: Jiménez-Báez Maria Valeria , Maravilla-Ulloa Ilinova , Rojas-López Brenda Michelle , Quiroz-Valdes Berenice de Jesús , Chavez-Hernández María Margarita , Sandoval-Jurado L , Enrique Leobardo Ureña Bogarín , Irma Archundia Riveros

Abstract

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Number of views: 234

Ovarian endodermal sinus tumors are a neoplasm of germinal origin derived from the primordial cells that during their migration from the caudal area to the gonadal region undergo mutations that progress to become malignant cells that proliferate constantly. Appearance is unilateral; it is considered the germinal tumor with the highest malignancy rate. (20%) Early diagnosis could increase patient survival. An exploratory investigation included the five last years in the pubmed, science, and Cochrane was carried out to evaluate the evidence of the diagnosis and / or treatment of these tumors. It was found that mortality is due to delayed diagnosis and ineffective treatment. It is necessary to determine the chemotherapy treatments that effectively attack this type of neoplastic cells, which behave differently from other types of tumors.