Jurnal Medical Brasovean

1

Authors: Liliana Rogozea

Deși măsurile stricte de prevenție și de respectare a igienei mediului, locuinței și a celei individuale sunt singurele măsuri eficiente la ora actuală, în lipsa unui vaccin sau a unei terapii țintite, totuși campaniile de educație pentru sănătate au fost nu numai reduse ca număr, dar și aproape lipsite de reflexie în presa nemedicală. Astfel, atât personalul medical cât și misionarii sau mass-media care s-au ocupat de afecțiune au încercat să prezinte cu lux de amănunte evoluția numărului de cazuri, modul de răspândire a acestora, dar nu există informații despre numărul de campanii de sănătate duse în această perioadă sub egida OMS sau a altor organizații non-guvernamentale. Această reflexie amară m-a făcut să mă reîntorc în timp, la campania din 1938 din România, care a inclus un număr foarte mare de prelegeri de educație pentru sănătate, sau la preocuparea constantă din Gazeta de Transilvania din secolul al XIX-lea și începutul secolului XX, în care medici celebri din Brașov susțineau educația populației prin articole scrise cu regularitate.

3

Authors: Nicoleta Taus, Main Farraj

Glutathionperoxidase is an enzyme that catalyses the reduction of hydroperoxides, including hydrogen peroxide, glutathione reduction. Glutathione peroxidase has the function to protect cells from oxidative stress-induced changes. Toxicological studies have demonstrated the production of reactive oxygen species by titanium dioxide nanoparticles. In the present study, it was shown experimentally change in the enzyme glutathione peroxidase in guinea pigs that was implanted titanium screw.

4

Authors: Evelina Enășcuț, Dan Minea

Cerebrovascular disease is a leading cause of death worldwide. Stroke, ischemic or haemorrhagic, is accompanied by changes in all body systems. Among these, in literature is described the neurogenic heart disease. This represents all cardiovascular consequences arising in the context of acute brain pathologies. It includes: variations in blood pressure, left ventricular dysfunction, arrhythmias and sudden cardiac death.

4

Authors: Laura Larisa Dracea

Bacterial resistance is a serious health problem all over the world and a major topic to be discussed, therefor should be a focus for all those who are engaged in the battle against infections. Over the last few decades, there are strong signals coming from medical research and international organizations, that there are observed new, dangerous and antibiotic resistant bacteria. Profiles of bacterial species that are particularly concerning and factors that are contributing to emergence of resistance are discussed in this review. Strategies in fighting against this phenomenon and prescription optimisation based on knowledge about resistance acquiring mechanisms and therapeutic approaches in specific fields have to be developed and implemented in current practice.

4

Authors: Andrea Neculau, Nicolau Andrada, Florin Leașu, Liliana Rogozea

Prominent Romanian medicine figure, Jacob Felix is part of people who were not only perfectly integrated in their country of adoption, but have also greatly contributed to its prosperity. Equally concerned of hygiene and health organization problems, he bequeathed us a treatise on history of hygiene in 3 volumes that can be used today as a model of organizing information in the field. Unfortunately not all of his lectures have been retained, but studied documents shows that Felix was a very active person in medical and socio-political life, representing a model in this direction.

4

Authors: Dan L. Dumitrașcu

This is an essay dedicated to the issues linked to medical elite. The author defines the meaning of elite and describes the medical elite. The focus is put on the aspects that impose the elite: achievements in clinical practice, or in medical education or in biomedical research. Of course, the true elite is challenged by the false elite, pushed by charlatanerie. However, true members of the medical elite are able to resist to the passing of the time.

5

Authors: Călin Cobelschi, Adrian Maier, Iulian Toader, Alen Alfred Redalf Gheorghiu, Mircea Hogea, Alina Mihaela Pascu, Adrian Bărăcan

Diabetes is a common disease in the contemporary world. Diabetic foot is one of the major complications of diabetes because of it’s major individual, economic and social impact. Infection of diabetic foot lesions increases the complexity of treatment and worsens the prognostic. Surgical treatment and antibiotic therapy represent milestones in the approach of diabetic foot infections. This paper describes a bacteriological survey of a lot of patients hospitalised in a surgery department for infected lesions of diabetic foot.

6

Authors: Diana Ungureanu, Dan Minea, Iosif Șamotă, Marius Moga

Cranial ultrasound examinations are performing on preterm newborns to provide information about neonatal brain injury for the prediction of long term neurological outcomes. Because of recent developments in the technology and process of performing cranial ultrasound examinations, and in the classification and understanding of the predictive value of abnormal findings, it is timely and important to consider the value for cranial ultrasound screening in neonatal intensive care units (NICUs).

6

Authors: Nadinne Roman, Angela Repanovici, Liliana Rogozea

The concept of medical ethics occurred with the development of medical ac and medical science to help the main character of health system-the patient. The basic principles of bioethics focused on beneficence and on patient autonomy are complementary with medical rehabilitation specialization, converging to the same destination: patient independence. Over the last decade both disciplines have benefit from expansion and development, but most often not converged, being raised ethical and moral judgment related to behaviour and conduct of medical staff and reported in the scientific and academic therapists activity. This work wants to raise awareness of physical therapists and medical specialists in recovering, providing data on the evolution of these disciplines.

7

Authors: Andrada Nicolau

Epidemiological studies suggest that almost the entire world population has suffered or suffer from one or another form of periodontitis. The permanent tooth affected by caries in children has skyrocketed. The article is a brief overview of the issues related the epidemiology of dental caries and periodontitis, based on the literature in order to understand the phenomenon represented by some of the most common human diseases and their implications on the health of the population. Understanding the factors that influence the occurrence of periodontitis underpins the development of health education programs capable of improving the health of the population and to assure the development agenda at the institutional level to be involved not only dentists, but also general medical practitioner or teachers from the level of education, especially preschool and school.

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Authors: Cătălina Croitoru,Overcenco Ala, Opopol Nicolae, Pantea Valeriu, Crudu Petru, Barbă Oleg

The phenomenon of climate change has driven appearance of a multiplicity of studies in medicine as an argumentation for elaboration of adaptation measures. It was investigated a number of death cases in cold season (November-March) of very cold winters 2005/2006 and 2009/2010 compared with the period of reference (2001-2010) in 4 regions of the Republic of Moldova. During these cold winters the significant increase both in the absolute number of deaths and in excess deaths has been registered, that is directly correlated with very low temperatures of corresponding periods. At the same time the number of excess deaths was about three times higher during 2009/2010 compared to 2005/2006 (0.001

1

Authors: Liliana Rogozea

Începutul este întotdeauna legat de visele pe care ni le facem în adolescență, de valorile morale pe care ne construim aceste vise, pentru că așa cum spunea Paulo Coelho în Alchimistul: „Toţi oamenii la adolescenţă ştiu care este legenda lor personală. În acest moment al vieţii, totul este limpede, totul este posibil şi oamenii nu se tem să viseze şi să dorească ce le-ar plăcea să facă. Cu toate acestea, pe măsură ce timpul trece, o forţă misterioasă încearcă încet, încet să dovedească faptul că legenda personală este imposibil de realizat. Sufletul lumii se hrăneşte cu fericirea oamenilor, sau cu nefericirea, cu invidia, cu gelozia. Împlinirea legendei personale este singura îndatorire a oamenilor.”

4

Authors: Daniela Voda

In this prospective study I presented the efficiency / toxicity of iron chelation therapy for 8 children with β thalassemia major, hospitalized in Children Hospital Brasov between march 2011-march 2013. Evaluation of hemochromatosis based from level of serum ferritin (every 3 month), echocardiography (every 6 month), abdominal ultrasound (every 3 month), and complete growth assessment (every 6 month). I evaluated desferrioxamine toxicity by yearly ophthalmology and audiology examination and deferasirox toxicity by biochemistry every month (ALT, AST, and creatinine).

4

Authors: Daniela Drăguș

One of the major issues pharmaceutical companies confront themselves with in the commercial practice is related to the replacement of innovative drugs with generic ones, a much cheaper alternative, and at the same time, a lot more accessible to the patients. Comparing generic and innovative drugs it must be pointed out that both of them have to respect certain standards (related to purity, efficacy) and have the same active substances; the difference consists in the quantity of inactive substances or the organoleptic differences between them. From an ethical point of view, the use of generic drugs increases the population’s accessibility to these drugs, but it raises various issues related to how much the patients are informed about this, how the efficacy of these drugs has been verified or their safe use.

5

Authors: Marius Moga, Cosmuță Adina, Nicușor Bîgiu, Petru Ifteni, Victoria Burtea, Alina Pascu

Multiple sclerosis (MS, SM) is a condition that interferes with the decision of having a child because of the complex associated-morbidity and treatment. This paper indentifies and highlights the importance of a reliable evaluation of the relationship MS – pregnancy. We can hereby conclude how the pregnancy influences the evolution of MS and also in which degree the MS influences the evolution of the puerperium. Therefore, to ensure a good management of this complex situation, this article proposes some indications to be taken into account whenever this morbid association occurs.

5

Authors: Mimoza Velickovski, Bedri Veliu, Radmila Maksimovska-Simonovska, Gordana Ristovska

Article is a retrospective study based by a questionnaire survey for quantifying annoyance and the sleep disturbance level within the adult population. The conclusion of the study is that population in Kumanovo who live and work in trade-business-residential and residential areas were exposed to increased noise level and they reported annoyance and sleep disturbance.

6

Authors: Ştefania Diaconu, Radu Mircea, Bogdan Cârlan, Oana Falup-Pecurariu, Monica Moarcăş, Cristian Falup-Pecurariu

Traumatic brain injury is a frequent medical condition that major affects the patient’s quality of life. Sleep disorders represent important consequences of traumatic brain injuries, both in the acute or chronic phase following the trauma. Posttraumatic sleep disturbances include hypersomnia, insomnia, narcolepsy, sleep apnoea and circadian sleep-wake disorders. The aim of this study is to review the clinical aspects and the epidemiology of these particular sleep disorders, the most important assessment tools (subjective methods like scales or objective measurements like polysomnography) and their management.

6

Authors: Anamaria Raluca Badea, Laurențiu Nedelcu

Cardiac autonomic neuropathy (CAN) is one of the most common complications of diabetes mellitus. CAN is recognized as a strong independent predictor for cardiac events, it increases both mortality and morbidity risk in diabetic patients. The imbalance between sympathetic and parasympathetic nervous system due to an impaired autonomic function is leading to an increased arrhythmic risk. Heart rate variability (HRV) reflects the cardiac autonomic function and a reduced HRV in diabetic patients reflects a sympathetic dominance. In clinical practice HRV measurements are obtained with an analysis of RR fluctuations in continuous ECG monitoring. HRV indexes are analysed in time and frequency domains. Further researches are required to standardize HRV indexes by gender and age.

7

Authors: Cristian-Adrian Constantinescu, Elena-Mihaela Constantinescu

The incidence of Helicobacter pylori infection is between 3-10% of the population per year in developing countries and 0.5% per year in developed countries. There are significant correlations between the prevalence of H. pylori infection, hygiene and living conditions of childhood. The natural reservoir of H. pylori infection is human, describes many possible routes of transmission: oral-oral, fecal-oral, gastro-oral, iatrogenic, aquatic and zoonotic Based on genetic differences, H. pylori have been classified in seven varieties, with different geographical distribution, prevalence specific ethnic groups. Suggested origin of H. pylori infection is in East Africa, from where it spread ago a hundred thousand years The first form of the disease, which manifests itself in all patients infected with H. pylori is active chronic gastritis. Later complications occur or developments such chronic gastritis to ulcer disease and gastric cancer.

8

Authors: Gheorghe Banu

Trekking is not practised only by apparently healthy people, but also by an increased number of subjects with risk factors associated with subclinical or diagnosed cardiovascular diseases, with or without treatment. This study has focused on a sample of 56 subjects belonging to the age group 46-55 years, and is part of an ample research on a group of 164 trekkers, aged between 35 and 65 years. They were monitored by measuring the blood pressure, heart rate and electrocardiogram on a route between Bușteni (850 m), up the Cerbului Valley (2000 m) to Omu Peak (2500 m) and back. The conclusions were: for the untreated hypertensive, blood pressure jumps determine more frequently cardiovascular events with clinical expression of angina of effort and electrocardiographic changes of ischemic ST -T; treated hypertensive patients have moderate tolerance to climbing effort with ischemic ECG changes in dynamics; cardiovascular events of the type: angina, arrhythmias, myocardial sequelae were not complicated with fatal or non -fatal events.