Jurnal Medical Brasovean

1

Authors: Liliana Rogozea

Începutul este întotdeauna legat de visele pe care ni le facem în adolescență, de valorile morale pe care ne construim aceste vise, pentru că așa cum spunea Paulo Coelho în Alchimistul: „Toţi oamenii la adolescenţă ştiu care este legenda lor personală. În acest moment al vieţii, totul este limpede, totul este posibil şi oamenii nu se tem să viseze şi să dorească ce le-ar plăcea să facă. Cu toate acestea, pe măsură ce timpul trece, o forţă misterioasă încearcă încet, încet să dovedească faptul că legenda personală este imposibil de realizat. Sufletul lumii se hrăneşte cu fericirea oamenilor, sau cu nefericirea, cu invidia, cu gelozia. Împlinirea legendei personale este singura îndatorire a oamenilor.”

4

Authors: Daniela Voda

In this prospective study I presented the efficiency / toxicity of iron chelation therapy for 8 children with β thalassemia major, hospitalized in Children Hospital Brasov between march 2011-march 2013. Evaluation of hemochromatosis based from level of serum ferritin (every 3 month), echocardiography (every 6 month), abdominal ultrasound (every 3 month), and complete growth assessment (every 6 month). I evaluated desferrioxamine toxicity by yearly ophthalmology and audiology examination and deferasirox toxicity by biochemistry every month (ALT, AST, and creatinine).

4

Authors: Daniela Drăguș

One of the major issues pharmaceutical companies confront themselves with in the commercial practice is related to the replacement of innovative drugs with generic ones, a much cheaper alternative, and at the same time, a lot more accessible to the patients. Comparing generic and innovative drugs it must be pointed out that both of them have to respect certain standards (related to purity, efficacy) and have the same active substances; the difference consists in the quantity of inactive substances or the organoleptic differences between them. From an ethical point of view, the use of generic drugs increases the population’s accessibility to these drugs, but it raises various issues related to how much the patients are informed about this, how the efficacy of these drugs has been verified or their safe use.

5

Authors: Marius Moga, Cosmuță Adina, Nicușor Bîgiu, Petru Ifteni, Victoria Burtea, Alina Pascu

Multiple sclerosis (MS, SM) is a condition that interferes with the decision of having a child because of the complex associated-morbidity and treatment. This paper indentifies and highlights the importance of a reliable evaluation of the relationship MS – pregnancy. We can hereby conclude how the pregnancy influences the evolution of MS and also in which degree the MS influences the evolution of the puerperium. Therefore, to ensure a good management of this complex situation, this article proposes some indications to be taken into account whenever this morbid association occurs.

5

Authors: Mimoza Velickovski, Bedri Veliu, Radmila Maksimovska-Simonovska, Gordana Ristovska

Article is a retrospective study based by a questionnaire survey for quantifying annoyance and the sleep disturbance level within the adult population. The conclusion of the study is that population in Kumanovo who live and work in trade-business-residential and residential areas were exposed to increased noise level and they reported annoyance and sleep disturbance.

6

Authors: Ştefania Diaconu, Radu Mircea, Bogdan Cârlan, Oana Falup-Pecurariu, Monica Moarcăş, Cristian Falup-Pecurariu

Traumatic brain injury is a frequent medical condition that major affects the patient’s quality of life. Sleep disorders represent important consequences of traumatic brain injuries, both in the acute or chronic phase following the trauma. Posttraumatic sleep disturbances include hypersomnia, insomnia, narcolepsy, sleep apnoea and circadian sleep-wake disorders. The aim of this study is to review the clinical aspects and the epidemiology of these particular sleep disorders, the most important assessment tools (subjective methods like scales or objective measurements like polysomnography) and their management.

6

Authors: Anamaria Raluca Badea, Laurențiu Nedelcu

Cardiac autonomic neuropathy (CAN) is one of the most common complications of diabetes mellitus. CAN is recognized as a strong independent predictor for cardiac events, it increases both mortality and morbidity risk in diabetic patients. The imbalance between sympathetic and parasympathetic nervous system due to an impaired autonomic function is leading to an increased arrhythmic risk. Heart rate variability (HRV) reflects the cardiac autonomic function and a reduced HRV in diabetic patients reflects a sympathetic dominance. In clinical practice HRV measurements are obtained with an analysis of RR fluctuations in continuous ECG monitoring. HRV indexes are analysed in time and frequency domains. Further researches are required to standardize HRV indexes by gender and age.

7

Authors: Cristian-Adrian Constantinescu, Elena-Mihaela Constantinescu

The incidence of Helicobacter pylori infection is between 3-10% of the population per year in developing countries and 0.5% per year in developed countries. There are significant correlations between the prevalence of H. pylori infection, hygiene and living conditions of childhood. The natural reservoir of H. pylori infection is human, describes many possible routes of transmission: oral-oral, fecal-oral, gastro-oral, iatrogenic, aquatic and zoonotic Based on genetic differences, H. pylori have been classified in seven varieties, with different geographical distribution, prevalence specific ethnic groups. Suggested origin of H. pylori infection is in East Africa, from where it spread ago a hundred thousand years The first form of the disease, which manifests itself in all patients infected with H. pylori is active chronic gastritis. Later complications occur or developments such chronic gastritis to ulcer disease and gastric cancer.

8

Authors: Gheorghe Banu

Trekking is not practised only by apparently healthy people, but also by an increased number of subjects with risk factors associated with subclinical or diagnosed cardiovascular diseases, with or without treatment. This study has focused on a sample of 56 subjects belonging to the age group 46-55 years, and is part of an ample research on a group of 164 trekkers, aged between 35 and 65 years. They were monitored by measuring the blood pressure, heart rate and electrocardiogram on a route between Bușteni (850 m), up the Cerbului Valley (2000 m) to Omu Peak (2500 m) and back. The conclusions were: for the untreated hypertensive, blood pressure jumps determine more frequently cardiovascular events with clinical expression of angina of effort and electrocardiographic changes of ischemic ST -T; treated hypertensive patients have moderate tolerance to climbing effort with ischemic ECG changes in dynamics; cardiovascular events of the type: angina, arrhythmias, myocardial sequelae were not complicated with fatal or non -fatal events.