Current Research in Pharmaceutical Sciences

95-105

Authors: Rajesh Kumar Jatav, Manish Bodana and Rakesh Kumar Jatav

The purpose of this study was to formulate floating tablet of cefadroxil using hydoxy propyl methyl cellulose K 100 M, Carbopol 934 P, gas generating agent sodium bicarbonate and citric acid. The present investigation concerns the development and evaluation of floating tablets of cefadroxil which, after oral administration, are designed to prolong the gastric residence time. The granules were prepared by wet granulation method and evaluated for their granules property. In these formulations PVP-K30 was used as granulating agent by dissolving it in isopropyl alcohol. PVP-K30 used in all formulations, which is responsible for preparing good tablets. Tablets were compressed by using hand operated single punch tablet machine and evaluated with different parameters like diameter, thickness, average weight, hardness, friability, drug content, in vitro drug release study and swelling characteristics etc. All the formulations batches from F1 to F10 were evaluated for thickness measured by Vernier caliper, thickness were in the range of 5.8±0.06 to 6.2±0.01 mm. The hardness of tablets were in the range of 4.3 to 6.4 kg/cm2 measured by Monsanto hardness tester. The friability was in the range of 0.77 to 0.99 %. The values of average weight were in the limit. Drug content was in the range of 97.01 to 99.69 indicating good content uniformity in the prepared formulation. Floating lag time were in the range of 78 to 175 Sec. The result of in vitro drug release studies showed the optimized formulation (F10) could sustain drug release (95%) for 8 hours and remain buoyant for 8 hours. Floating lag time and total floating time of formulation F10 was 110 sec and 480 min respectively. Swelling index of tablets is also determined at a time interval of 1 hour to 5 hour. Swellings of all the batches were performed and they are in the accepted range.