International Journal of Graduate Research and Review

Number Vol-3(2), 2017

23-24
Yoga for Healthy Life

Authors: Umesh P. Shrivastava

Abstract

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No abstract

25-28
In-Silico Drug Discovery Approach to Cancer

Authors: Adhithi Venkatesh, Aishwarya.V.A. Sasty, Anish Raju and Pradeep. S

Abstract

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Cancer is the abnormal proliferation of cells, when there is an internal or external agent, physical, biological or chemical agent involved. Cancer can be due to viruses, radiations, chemical or sometimes even genetic. This particular paper shows a few tools that were used in determining the to study and analyse a few different bioinformatics tools to come to study about an in-silico drug discovery approach. A few tools that were used were RAMPAGE- to obtain the Ramachandran plot, RCSB- to obtain the 3-D structure of the protein, RasMol- to visualize and obtain the proteins and ligands that can bind to it, PubChem- to obtain the 3-D structure, physicochemical and ADMET properties of the drug, HEX- to visualize and study the binding and docking properties of the drug with the target protein sand gene receptor, Superpose- to study multiple sequence alignment data and superpose with other proteins using homology modelling.

29-37
Varietal Screening of Wheat Genotypes/Varieties against Helminthosporium Leaf Blight (Bipolaris sorokiniana) at Rampur, Chitwan, Nepal

Authors: Aman Bhatta, Dinesh Marasini , Bishal Khadka, Yogendra Raj Upadhya, Sarita Lamichhane, Dipa Shrestha, Anuma Dangol

Abstract

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Screening of 20 wheat varieties/genotypes obtained From National Wheat Research Program, Bhiarahawa, Nepal, against spot blotch, caused by Bipolaris sorokiniana, was conducted in a RCBD during December 2014 to April 2015 in field of agronomy research block at Institute of Agriculture and Animal Science (IAAS), Rampur, Chitwan, Nepal. Each variety/genotype has 3 plots of 1.25m2 as replication. Disease incidence was recorded and intensity measured by calculation mean area under disease progress curve (AUDPC) from single digit disease scores taken at 78, 83, 88, 93 and 98 days after sowing (DAS) respectively. Yield and yield attributing characters were recorded. Genotypes with AUDPC values from 101-200, 201-400 and 401-600 were categorized as resistant, moderately resistant and susceptible respectively. Spot blotch started to appear after 63 DAS only on RR 21, in many varieties/genotypes it started to appear on an average of 68-69 DAS and in NL 1094 lastly on 82 DAS. The highest AUDPC values of wheat varieties/genotypes 419.26 and TGW 41.10g. Maximum disease was found during last week of March to first week of April as maximum and minimum temperature, rainfall and relative humidity were 340C, 190C, 25.5 mm and 78% respectively. The BL 3623 Gautam varieties/genotypes were resistant. These varieties/genotypes had lower disease and higher yield and yield attributing characters. Therefore they can be used as source or resistance to spot blotch in breeding programs. The variety RR 21 appears most susceptible to spot blotch, which can be used as a susceptible check.