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EFFECT OF VITAMIN E ON BENZENE INDUCED ALTERATIONS OF SOME ENZYMES OF CARBOHYDRATE METABOLISM AND OXIDATIVE STRESS IN RAT LIVER
Authors: Ganguly S., Patra S.K., Mandal S.K.
Number of views: 309
The effect of Vitamin E (1 mmol/kg body weight/day given intraperitoneally for 7 days before
the administration of benzene) on benzene (500 mg/kg body weight/day in corn oil) induced alterations
of some enzymes of carbohydrate metabolism and oxidative stress in rat liver was investigated. Control
group was give only corn oil. Each treatment was carried out for 20 days. Results revealed that
administration of benzene caused a significant increase in the levels of lactate dehydrogenase (LDH),
Lipid peroxidation and malondialdehyde (MDA). Whereas the levels of glucose–6 phosphatase, reduced
glutathione (GSH) superoxide dismutase (SOD) and Catalase were significantly decreased compared to
control animals. But in those animals which received Vitamin E therapy 7 days before being challenged
with benzene, the changes in those parameters were almost statistically non-significant. This study
indicated that, Vitamin E, a well known antioxidant can protect the major profiles of Carbohydrate
metabolism and normal oxidative state of liver from the detrimental effects of benzene at this
concentration.