Варненски медицински форум (Varna Medical Forum)

5-9

Authors: Meglena Angelova, Vanya Goranova, Dessislava Marinova, Stoyan Pavlov, Vesselina Mihaleva, Tetsumori Yamashima, Anton Tonchev

Cerebral cortex оf mammals is mainly generated during the embryonic period by stem cells and their derivative progenitors in the palium of the developing telencephalon. Various genes in complex interactions are involved in the processes of differentiation of the cerebral neurons. Transcriotional factor Sox2 plays a key role for self renewing and sustaining multipotency of embryonic neural stem/progenitor cells. Data about the expression and function of Sox2 in human fetal brain are insufficient and controversial. In the present sudy tissue samples of spontaneously aborted human fetuses aged between 12th to 28th gestational weeks (g. w.) were examined by a standard histological and immunohistochemical technique for paraffin sections. Sox2 expression was followed in the zones of cellular proliferation and migration in the occipital lobe of human fetal telencephalon mainly during 17th g. w. Within ventricular and outer subventricular zones we detected similar amount approximately 45% Sox2+ cells, whereas in the intermediate zone, cortical plate and marginal zone expression of Sox2 was not found. The data obtained on the location and expression dynamics of Sox2 contribute to a more complete understanding of neural stem/progenitor cell biology during embryonic neurogenesis in the human cerebral cortex.

15-20

Authors: Kader Dervisheva, Stefka Valcheva-Kuzmanova

On the Bulgarian market, the products containing Ginkgo biloba extract are three categories – medicinal products (MP) and food supplements (FS), which are mono-products and combined products. The purpose of this study was to analyze the use of products containing Ginkgo biloba extract in Bulgaria for the period 2011-2013 and by a questionnaire method to study the practice of doctors to prescribe such products. The market research is done according to data from IMS Health and by interviews with doctors from the regions of Varna and Dobrich. The results from the study showed that in the years 2011-2013 there was an increase in the sale of products containing Ginkgo biloba extract, both in number of packs sold and in terms of value at a relatively unchanging average package price. In the study period, the greatest was the increase in the use of MP. The greatest was the market share of the combined FS. The predominant share of combined FS cuold be explained by the greater variety and number of these products. The four products with the greatest market share were combined FS. The survey showed that almost all physicians prescribe products containing Ginkgo biloba extract. The most prescribed and recommended are the combined FS. Most often Ginkgo biloba containing products are prescribed for disturbances in blood flow and memory in patients above the age of 60. Decisive in the choice of a product is the combination of efficacy, quality and price.

25-28

Authors: Anna Todorova, Antoaneta Tsvetkova, Ana-Maria Velcheva, Maia Radeva, Kristina Decheva, Teodora Georgieva, Nadia Agova

In recent decades, both worldwide and in our country, there is a noticeable increase in allergic diseases, including those of respiratory system – bronchial asthma and allergic rhinitis. Epidemiological studies show that these conditions often coexist in the same patient. Allergen – specific sensitization is one of the major risk factors for the development of asthma in children. Allergic rhinitis usually precedes asthma. The premise “one respiratory system, one disease” marks a change in diagnostics and therapeutic treatment of respiratory allergies. Currently allergen-specific immunotherapy, administered in the early stage of the disease, is the only treatment that could have disease-modifying effect. The aim of this study is to analyze what proportion of children with asthma suffer from allergic rhinitis and what are the most common therapeutic schemes and practices used in the prophylaxis and treatment of the condition. For this purpose we conducted a survey among parents of children suffering from bronchial asthma on the territory of the city of Varna. Data were processes statistically based on respondent’s answers and were presented graphically. Results confirm that allergic rhinitis is a widespread disease among children with asthma and that is often neglected and not diagnosed and managed in time. Early diagnostics and adequate control of allergic rhinitis is crucial to stop the disease progression to asthma.

33-35

Authors: Ilia Todorov, Mariana Mihaylova, Todor Todorov

Introduction: The authors reveal the opportunities for a diagnosis and treatment with the methods of manual medicine of a muscle very often responsible for the cases of muscle dysbalance in the thoracolumbar passage, lumbar region and the lower extremities. In addition, the anatomic position and function of the muscle very often lead to the association of the clinical symptoms with other deceases. Objectives and tasks: Accomplishment of an effective treatment algorithm for dealing with the problem. Materials and methods: We have executed on a group of patients the most common techniques of manual diagnostics and have discovered the chain links between the observed pathology and other regions of the vertebral column – the thoracolumbar and lumbosacral passages. We also have shown the results of the manual therapy techniques applied – postisometric relaxation (PIR) as well as manual manipulation for the chain-linked blockages. The authors reveal the possible combinations of manual medicine and physical factors. Results: Of the 44 patients included in the study by 37 (84,09%) a pathology of the iliopsoas muscle has been found. By 36 of the mentioned 37 patients a complete relief of the pain symptoms has been achieved and by all of the patients with a change of the posture normalization occurred. Conclusion: The final results of the investigation prove the effectiveness of the exercised clinical approach in dealing with the pathology of m.iliopsoas. The manual diagnostics has proven itself as a leading method of tracking of the somatic dysfunction of a muscle, the effects of the applied PIR techniques decisively excelling the medication with non-steroid drugs.

39-40

Authors: Evgenia Vladeva

The article reveals the physicochemical characteristics of the sea lye, lixivium and particularly sea lixivium “Longoza”, the main healing agents during it’s usage and the indications for the treatment of different diseases.