Ukrainian Scientific Medical Youth Journal

6-11

Authors: Khajtovych M.V.

Personalized medicine it is a model of health care based on a selection of diagnostic, therapeutic and preventive means taking into account the genetic, physiological, biochemical and other features of the patient. Personalized medicine new branch of modern medicine, in which developed and applied treatments, “tailored” specifically for the individual patient. Areas of application of personalized medicine in modern terms: the transition from traditional to personalized clinical diagnosis of the disease based on individual patient parameters, including using different molecular biomarkers nature, and save biomaterial throughout his life; predictions based on genomic data likelihood of a disease with the development of individual preventive scheme; identification of potential pharmacotherapeutic targets for selective exposure at the initial stage of the pathological process; choice of treatment strategy tailored to the individual patient parameters; monitoring of treatment using biomarkers. Strengthening the role of clinical pharmacology and create genetically informed personalized medicine algorithms increase the efficiency and safety of pharmacotherapy. New technologies make it possible to clarify the causes adverse side effects at the genetic level, prevent, reduce treatment costs and significantly enhance its security and therefore implementation of these approaches in the long run will contribute to significant savings.

19-22

Authors: V.A. Ponyatovsky, V.V. Bobyr, V.B. Nastenko

The experimental work is devoted to modeling the enteroviral infections in animals with dysbiotic dysfunctions of intestine. As enterovirus, a vaccine strain of serotype 2 poliovirus was selected. The white 30 days old mice of Balb/ñ line that passed acclimatization were taken as an experimental model. Dysbiosis was formed by oral injection of combination of antibacterial preparations ampicillin and metronidazole in doses of 5, 10 and 20 mg/animal a day. The results of the researches showed that after oral injection of complex of ampicillin and metronidazole in laboratory animals formed pronounced dysbiosis. The optimum dose for modeling dysbiosis with these preparations was determined as 10 mg/animal. It was established that increasing the dose of antibacterial preparations does not impact on depth of dysbiotic displays in mice’s intestine and occurs only in decreased animal’s body weight. In addition, it is experimentally proved that the development of dysbiosis in mice promotes more rapid release of intestinal type 2 poliovirus. The term of virus’s evacuation in such animals lasted for 5-6 days, while in control group it took up to 10 days. It is suggested that bacterial cells might “mask” the viruses from the factors of immune protection and decrease of number of bacteria in the intestine after antibiotic therapy accelerates the ongoing release of the organism from viral antigens. It is possible that viruses are able to establish “symbiotic” relations with bacteria and, thus, stay longer in the intestine of animals, although, obviously there are other factors that affect the rate of excretion of viral antigens from animals’ organisms.

27-30

Authors: Y. Deyeva

Lecture gives modern views of the vestibular dysfunction problem in patients with diabetes mellitus. Actuality of the problem caused by the increasing number of disease and high patients disability. Vestibular disorders are one of the earliest complications arising in patients with diabetes mellitus and can serve as markers of diabetic complications process. These is various schemes of treatment and rehabilitation of vestibular dysfunction in patients with diabetes.

37-39

Authors: Yuriy Kovbasniuk

Atrial fibrillation is the one of the most common disorders of heart rhythm that occur in the population. Taking in account the increase in life expectancy it is predicted that in the next 50 years atrial fibrillation frequency will increase more than twice. Disease is associated with increased total and sudden deaths, increasing the risk of heart failure, decline of the life quality, but one of the most dangerous complications of this arrhythmia is the frequent occurrence of thromboembolism which in 75% of cases lead to cerebral event – the stroke. That was the reason to choose the most widely used in domestic medicine drug warfarin as the research object. The article is devoted to the prevention of thromboembolic complications in patients with atrial fibrillation. We consider the dose adjustment of warfarin should be based on age, sex, BMI, and the accompanying obesity.

44-48

Authors: N. Netyazhenko, Y. Antoniuk, Y. Oleynikova, O. Herula

In comparative gender analysis course of MI with ST-segment elevation of 156 patients who were divided into 2 groups: group I (n = 42 males, n = 38 female) – patients who completed PCI with stenting -dependent artery in terms of> 2 <6 hours from symptom onset and the second group (n = 36 males, n = 40 women) – patients who completed PCI in terms of> 6 <12 hours after onset of symptoms. Immediately after PCI during hospital period evaluated in patients develop fatal and non-fatal cardiovascular events: recurrence of pain, acute left ventricular failure class (ALVF) II-V by Killip, arrhythmias and conduction recurrence of MI, hemorrhage, mortality. The development of these events in patients regarded as a manifestation of adverse flow. Deferral> 6 hours in performing PCI in women is associated with an increase in the incidence of (ALVF) 37.2%, arrhythmias and conduction at 66.2%, recurrence of MI in 60.2% of mortality in 2,7 times compared with men (p <0.05). Conducting invasive reperfusion therapy for MI in women after 6 hours increases the frequency of ALVHF 2.3 times (p <0.001), arrhythmias and conduction 1.6 times (p <0,05), recurrence of MI in 3.9 fold (p <0,001) and mortality at 11.5 times (p <0,001) compared with women who PCI was carried out in terms of > 2 <6 hours.

54-57

Authors: Poladich I.V.

Multiple pregnancy is characterized by a high percentage of complications during pregnancy and childbirth. Clinical and statistical analysis of births in the Perinatal center of Kiev for the period of 2012-2014. For 2 years were 12326 births, of which multiple pregnancy - 432 (2.8%) cases. The article provides a comparative analysis of the course of pregnancy and childbirth in the bihorialnoy biamnioticheskoy twins in spontaneous pregnancy and after the use of assisted reproductive technology. We analyzed age, parity, obstetric and somatic history, type of placentation, application of assisted reproductive technologies, complications of pregnancy and delivery, timing and ways roorazrisheniya, obstetric and perinatal outcomes. A high frequency of obstetric and perinatal complications in women with multiple pregnancies resulting from assisted reproductive technologies is because they are at high risk of pregnancy and delivery in these patients is accompanied by a considerable number of complications, which are more pronounced in comparison with the self multiple pregnancy.

63-67

Authors: T. Tarasenko, O.Grynuk

The article presents the results of a retrospective analysis of the treatment of 111 patients with locally advanced ovarian cancer who received neoadjuvant chemotherapy at the first stage of treatment and those who recieved surgery treatment immediately. Most patients with locally advanced ovarian cancer were in the age range 46-66 years, namely 81% in the main group and 85% - in the control. With neoadjuvant chemotherapy is possible to reduce tumor size, particularly when canceromatosis of the peritoneum, improve resectability of the tumor, and also to increase the frequency of surgical debulking of the tumor. Also, the administration of the neoadjuvant chemotherapy increases resectability of tumors in patients with ascites. Using neoadjuvant chemotherapy increases one-year survival and 5-year survival. Median survival in the study group was 7 months and 5 month - in control group.

76-79

Authors: Sunus Akbari, Y.Kolenko, T.Timokhina

36 patients with cardiovascular disease were examined, namely, arterial hypertension and coronary heart disease. A total of 88,9 % of the examined had risk factors of osteoporosis. The study has showed that all patients with cardiovascular pathology are subject to some degree of periodontal tissue lesions, but most often was diagnosed generalized periodontitis III degree. All the patients with cardiovascular disease are needed to be searched for risk factors and clinical markers of osteoporosis. It is necessary to add antiosteoporotic therapy in complex treatment of periodontal diseases.

85-91

Authors: Chekman I.S.

Literature data and results of our department studies on theoretical and practical basics of nanoscience were summarized in the article. Much attention is paid to research in the field of physical, chemical, biological, medical, pharmacological, and toxicological properties of nanomaterials with the aim of their wider implementation into practice lately. The discovery of new wave properties of nanoparticles is of particular importance. The author of the article advances an idea: wave properties of nanomaterials play greater role with a decrease in particle size. The preponderance of wave properties compared with corpuscular ones in nanostructures determines a great change in their physicochemical properties and an increase in physical, mechanical, biological, pharmacological, and toxicological activity. The idea that was advanced in the article hasn’t been verified by theoretical or experimental studies for now. Joining efforts of scientists of different scientific fields is needed. A confirmation of hypothesis by specific findings will be of great importance for medicine and pharmacology and promote an implementation of new efficacious preparations into clinical practice.

96-99

Authors: M.A. Stashkevych, L.V. Gayova, O.V. Stechenko, L.F. Osinska

The present study is devoted to the search of the new biological properties of poly-(3-aminopropyl)- syloxan surface complex with copper (II) ions (Cu2+- PAPS) which exhibits high antibacterial activity toward strains which cause gastric and duodenal ulcer. The relevance of the usage of copper containing complex is stipulated by the fact that copper plays the important role in the various metabolic processes in human body: in biological oxidation, synthesis of macroergic compounds, formation of connective tissue proteins, iron metabolism. Copper (²²) is a cofactor of enzymes which are important for the protection of tissues from the active forms of oxygen – these are superoxide dismutase, cerruloplasmin, xantineoxidase, ascorbate oxidase etc. So copper containing compounds protect living cells from the oxidative stress, lipids and proteins oxidation, especially in biomembranes. The antioxidative activity of poly-(3- aminopropyl)-syloxan complex with copper (II) ions in the model systems with the usage of liposomes derived from the egg yolk and antiradical activity of this complex that was determined by the inhibition of p-nitrozolium chloride reduction by anion-radical generated in the photochemical system. The statistically significant decrease of the formation of malondialdehyde from the phospatidylcholine of the egg yolk after the addition of the investigational preparation with copper was demonstrated. The mechanism of the antioxidative activity of this preparation is obviously associated with the inhibition of the organic radicals, transformation of peroxide to the stable products of oxidation: alcohols, aldehydes, ketones. The obtained results evidence the moderate antioxidative and antiradical activity of the complex Cu2+-PAPS (up to 80% as compared to ionol and up to 60% as compared to cerruloplasmin). The obtained data confirm the reasonability of the further preclinical screening of the poly-(3-aminopropyl)-syloxan complex with copper (II) ions.

105-109

Authors: G. Moys³k, L. Trachuk, O. Golotsvan

The article describes research on the nature, level of alexithymia in patients with urolithiasis in women, the influence of autogenous training on the general condition of these patients. Also, the article describes a plan psychic correction support female patients with urolithiasis on the basis of the study data. Features character study were using the technique MMPI mini-mult. Based on the results, it is evident impact of physical illness to specific changes in nature: in patients with long course of urolithiasis compared to the control group are more pronounced manifestations isteroyidnosti, psychasthenia, schizoid. The level of alexithymia was determined using Torontivskoho aleksytymichnoho test. Results of the test found that among patients with urolithiasis compared to the control group higher level of alexithymia. Relaxation technique was performed by Schulz to patients. Effect of autogenous training on the overall functional state of mind, the mood was determined by a test Luscher. The results indicate a reduction in anxiety levels, compensation for stress, improve mood in patients with urolithiasis after autogenous training. Based on the survey results, taking into account identified in the study traits of women with urolithiasis, these patients recommended psycho support in the form of art therapy, body-oriented therapy, relaxation techniques, group and individual therapy to reduce the level of alexithymia, reducing and isteroyidnosti compensation manifestations, psychasthenia, schizoid. An integrated approach of medication, physical therapy and psychocorrection support will help, healing patients.

114-117

Authors: I. Tokarchuk

Creative atmosphere of medical education helps to improve its quality and provides opportunities to conduct scientific research for young specialists. Progresses of personality’s creative potential and creative self-realization in professional activities are very important conditions for specialist’s personality development. The period analyzed started with the second year of training, when students usually begin to attend surgical department. It showed the increasing interest during studying and great role of surgical scientific student’s society for career- guidance.