Studia Universitatis Moldaviae. Stiinte reale si ale naturii

12-20

Authors: Федор СТРУТИНСКИЙ, Ион МЕРЕУЦЭ, Валентина ЧОКИНЭ, Светлана ГАРАЕВА, Галина ПОСТОЛАТИ, Лилия ПОЛЯКОВА, Марьяна ЧОКИНЭ, Виктория БОГДАН

The nature of amino acid metabolism during infection with SARS-CoV-2 remains poorly understood to date. In this study, for the first time, studies on the effect of SARS-CoV-2 coronavirus infection on amino acid metabolism in the conditions of the Republic of Moldova are presented. It was found that the pool of amino acids in blood serum and erythrocytes in patients with COVID-19 is unbalanced, which creates tension in protein metabolism.

29-34

Authors: Anatolii MOGÎLDA, Galina LUPAȘCU

One of the most efective strategies to control fungi is to obtain germplasm resistant to this disease. This article presents data on the reaction of 40 sesame samples by treating the seeds with culture filtrate (FC) of the fungus of F. solani. The study of the cluster analysis (k-averages) of the set of lines and varieties in the FC variant include 22 genotypes with the highest germination, root length and stem length. The genotypes L1, Zaltsadovski, K-1257, K-1748 and Liano are represented by the highest values of agronomic importance by number of capsules per plant – 50.5-53.8, the number of seeds per capsule – 56.7-68.1 and productivity per plant of 7.4 - 10.1 g.

42-50

Authors: Nina CIOCÂRLAN

Scutellaria L. is a therapeutically important genus widely used in folk and modern medicine. It is a rich source of bioactive compounds, mainly flavonoids and diterpenes with anti-inflammatory, antioxidant, anticonvulsant, antiviral, antibacterial, anticancer, hepatoprotective and neuroprotective activities. The paper presents a review on medicinal impor¬tance of eight Scutellaria taxa introduced and studied in the National Botanical Garden (Institute) “Al. Ciubotaru”. The review on ethnobotanical, phytochemical and pharmacological literature indicates the great therapeutic potential of the species, which points the way to conduct further multidisciplinary studies in order to establish and explore their medicinal and economic value.

56-65

Authors: Ștefan RUSU, Dumitru ERHAN, Ion TODERAȘ, Maria ZAMORNEA, Viorelia RUSU, Galina MELNIC, Ion GOLOGAN

The aim of the study was to evaluate the impact of mono- and multiparasitic invasions on some morphologic and functional indices in boars. The findings revealed the number of eosinophils in the non-infested Group I, comparatively to 18.0%, within Group II spontaneously infested with Strongyloides ransomi; compared to 40.8%, decrease in Group III spontaneously infested with Dicrocoelium lanceolatum, and compared to Group IV of boars with multi-parasitic invasions (Dicrocoelium lanceolatum, Strongyloides ransomi, Metastrongylus elongatus and Eimeria debliecki). The findings in the boars from Group II spontaneously infested with Strongyloides ransomi revealed a 33.8% (P>0.05) decrease of the total proteins, as compared with animals from Group III – with a 19.5% (P<0,05) decrease, and those from Group IV – of a 37.7% (P<0.05) decrease, compared with Group I of the non-infested animals. It was established that the infesting of the boars with Strongyloides ransomi provokes a diminished number of pro-teinogram indices similar to changes in electropherograms of type I, which is specific to the acute inflammatory processes, due to the mechanic and spoiling effect of the rhabditid larvae that vehiculate the pathogenic microflora in the host organism during internal migration process.

70-78

Authors: Maria GONȚA, Larisa MOCANU, Vera MATVEEVICI

Pharmaceutical compounds are mostly non-biodegradable drug residues that have a removal efficiency of 20.0-50.0% by applying conventional methods, in comparison to the high efficiency obtained after the application of advanced oxidation processes. The main objective of this research was to determine the optimal oxida¬tion/¬minerali-zation conditions according to the physico-chemical parameters such as pH value, oxidant (H2O2) and catalyst con-centrations (Fe2+ and TiO2) that influence the oxidation of AMX and the evaluation of the degradation process of AMX in Fenton reagent and titanium dioxide systems. Initial reactant concentrations ranged from 0.01 to 0.3 mM for Fe2+, 0.1 to 0.5 g for TiO2 and 1.0 to 5.0 mM for H2O2. Homogeneous and heterogeneous oxidation of AMX was per-formed at a pH of 2.2 for the AMX/ Fe2+/H2O2/UV system and 3.5 for the AMX/TiO2/H2O2/UV system in aqueous solu-tions. The research methodology includes the study of oxidation/mineralization processes by determining the variation of chemical oxygen demand and substrate concentration using spectrophotometric methods. As a result of the process of optimizing the physico-chemical parameters, it has obtained that the maximum rate of mineralization/oxidation by Fenton oxidation achieved 96.0%, and the degradation rate – 90.0%. In the presence of titanium dioxide, efficiency is lower for degradation rate – 65.0% and achieved 97.0% form oxidation/mineralization rate. Although a high rate of oxidation/mineralization has been obtained, the COD values are high (11.9-12.5 mgO/L), which indicates the presence of stable organic compounds.