Studia Universitatis Moldaviae. Stiinte reale si ale naturii

3-16

Authors: Ana BÎRSAN, Aurelia CRIVOI, Iurie BACALOV, Maria FRUNZĂ, Veaceslav REVA, Silvia STRATULAT, Drăgălina BÎRSAN

In view of analysing this topic, specialised literature sources available in the MSU library and in the NCBI, MedPUB, Google scholar databases were selected. The analysis of these sources was carried out starting from the main medicinal plants used in the treatment of respiratory diseases: Althaea officinalis L., Hedera helix L., Hippophae rhamnoides L., Inula helenium L., Malva sylvestris L., Marrubium vulgare L., Origanum vulgare L., Plantago major L., Primula veris L., Sambucus nigra L., Silybum marianum L., Taraxacum officinale L., Thymus vulgaris L., and Tussilago farfara L. The results of the study allowed the identification of medicinal plants with anti-inflammatory activity, which could serve as potential sources of prophylaxis/treatment in the case of COVID-19. For all selected plants, scientific evidence was presented with regard to their anti-inflammatory activity, which indicates on the possibility of using these plants in mitigating the symptoms in COVID-19.

26-33

Authors: Ион МЕРЕУЦЭ, Федор СТРУТИНСКИЙ, Светлана ГАРАЕВА, Лилия ПОЛЯКОВА, Владимир КАРАУШ, Галина ПОСТОЛАТИ, Марьяна ЧОКИНЭ, Виктория БОГДАН

The COVID-19 pandemic poses a major threat to human health and life. Elderly people with low immunity are at a particular risk. To discover the mechanisms of coronavirus influence on the human body, an important role is assigned to the study of the influence of coronavirus on amino acid metabolism. The article presents results on the age-related peculiarities of amino acid metabolism in patients infected with the SARS-CoV-2 virus.

39-43

Authors: Elisaveta ONICA, Ion ROȘCA, Alina CUTCOVSCHI-MUȘTUC

The bioecological peculiarities of growth, development and cultivation of Prinsepia uniflora Batalin plants are described in this article. This shrub can be propagated by generative and vegetative methods, namely, by lignified cuttings and by layering. Early autumn fresh seeds sowing at a depth of 2-3 cm was the optimal and most cost-effective method of propagation. The germination capacity of the seeds sown in autumn varied in the research years, from 60 to 65% and of those incorporated in spring after stratification was only 40-45%, depending on the climatic conditions, following the cultivation techniques throughout the growing season. The plants are valued for their decorative qualities, in early spring – for the abundant, white flowers, and in early autumn – for the hanging branches full of black-purple fruits. It is recommended for use in landscaping in rural and urban areas of the country.

49-53

Authors: Vasile TODIRAȘ, Maria MELNIC, Svetlana PRISACARI, Angela LUNGU, Ștefan RUSU, Dumitru ERHAN

The stimulatory effect of the nodule bacterium Rhizobium on the growth, development and productivity processes in tomato and cucumber plants was studied. It has been established that treating seeds with bacterial metabolites in optimal concentrations (1:300; 1:500) stimulates the growth and accumulation of dry mass of plants. The effect of bacteria on phytoparasitic nematodes – Ditylenchus destructor – was also investigated.

60-65

Authors: Iurie BACALOV, Aurelia CRIVOI, Elena CHIRIŢA, Ana BÎRSAN, Adriana DRUŢA, Dragoș GHERAS

The PHASC-5 biopreparation leads to the improvement of the functional state in the pathology of the endocrine pancreas by removing or reducing the complications in the case of people suffering from diabetes. Thus, blood sugar is reduced and the hormonal balance is restored due to the bioactive principles it contains. The administration of PHASC-5 biopreparation in experimental diabetes allows to eliminate or even exclude the occurrence of acute and chronic complications in this pathology.

75-81

Authors: Tamara SÎRBU, Ion TIMUȘ, Olga ȚURCAN, Cristina MOLDOVAN, Viorina GORINCIOI

The last important stage of lyophilisation is rehydration, which has a major influence on the viability of microorganisms. Various nutrient media, skim milk, distilled water, etc. are used as rehydration media for lyophilised micromycetes. In this study, distilled water and nanoparticle (NP) solutions Fe2O3 and Fe2ZnO4 in a concentration of (mg/l): 0.05; 0.1; 1.0 were used for the rehydration of lyophilised strains of micromycetes. The obtained results showed that the solutions of NP Fe2O3, and NP Fe2ZnO4, in a concentration of 0.1 mg/and 0.05 mg/l, had a different influence on the viability of micromycetes. In some strains of the genus Penicillium there was a stimulation of viability of 7-8%, and in others a decrease of 6-9%, compared to the control variant. The viability of strains of the genus Aspergillus and Trichoderma decreased by 5-10% when using NP at a concentration of 0.05 mg/l, and at a concentration of 0.1 mg/l varied within ± 2-3%, compared to the control variant.

93-102

Authors: Ilie BOIAN, Rodion DOMENCO

With the help of modern statistical programs, the present study carried out the generalised climatic and agro¬climatic characterisation of the spring season on the territory of the Republic of Moldova based on factual data for the last 50 years, with the elaboration of maps of the distribution of multiannual average air temperature of precipitation in the spring season. Also, the springs of the last two decades (2001-2020) were analysed from a climatic and agroclimatic point of view, two anomalous springs being selected according to the thermo-pluviometric regime (2007 and 2012). For these springs, maps were developed regarding the distribution of the average air temperature and the amount of preci¬pi-tation, as well as the distribution of the values of the respective deviations from the norm for each evaluated spring season, and the analysis of these maps made possible the climatic and agroclimatic evaluation of the selected anomalous springs. The very high thermal regime and the significant deficit of precipitation, signalled in particular during the month of May in both anomalous springs (2007 and 2012), contributed to the drying of the upper layer of the soil, which created unfavou¬ra¬ble conditions for the growth and development of autumn crops and spring cereals and for the emergence of hoeing crops.

109-114

Authors: Tudor LUPAŞCU, Mihai CIOBANU, Oleg PETUHOV

Inflection points of strontium ion adsorption isotherms on CAN-7 and oxidized CAN-8 activated carbons were studied. The causes of inflection points on strontium ion adsorption isotherms on CAN-7 and oxidized CAN-8 activated carbons, obtained in the laboratory from walnut shells were identified. Studies have shown that the bonds between Sr(OH)+ and strong and weak carboxylic groups in the micropores and supermicropores of CAN-7 activated carbon are stronger than those in mesopores and macropores. The differential heating curve (DTA) of strontium ions adsorbed on CAN-7 has two thermal effects: one endothermic and the other exothermic.

119-125

Authors: Viorica GLADCHI

The article is an analysis of statistical data on emissions of pollutants into the air from various sources in the Republic of Moldova during 2015-2019. The mobile and stationary sources of pollutant emissions are highlighted, the dynamics and their polluting effect are analysed, as well as the influence of pollutant emissions on the environment and the health of the population.

132-140

Authors: Olga GARBUZ, Ion TODERAS, Nadejda RAILEAN, Victor TAPCOV, Aurelian GULEA

Based on the known methods and their modifications, 3 compounds were synthesized: 2-formylpyridine N(4)-phenyl¬thiosemicarbazone, complex copper(II) [Cu(L)Cl] with 2-formylpyridine N(4)-phenylthiosemicarbazone ligand, copper(II) mixed-ligand complex chloro(N-phenyl-N'-[(pyridin-2-yl)methylidene]carbamohydrazonothioato)(4-aminobenzene-1-sulfonamide)copper [Cu(Str)(L)Cl]. The antiproliferative properties of these compounds towards cancer cell lines MeW-164 and HeLa have been investigated. The tested compounds demonstrated antiproliferative and selective activity towards cancer cells. The tested compounds inhibit the activity of LOX. Direct toxic evaluation of compounds was performed by Daphnia magna bioassay. It was found that the tested compounds have a lower toxicity than DOXO. Theoretical pharma¬cokinetics (Lipinski's rule, PSA) of CMT-22, CMT-67 and CMT-68 supports further in vivo studies.

149-157

Authors: Елена ТУТОВАН, Татьяна ИСАК-ГУЦУЛ

The adsorption of methylene blue dye (MB) on native natural tripol was studied. It has been established that MB adsorption on tripol increases with the growth of pH. The form of the MB adsorption isotherm on tripol is of the Langmuir type. There were determined the constants from the Langmuir isotherm (qmax = 107.527 mg/g, K = 0.046 L/mg) and Freundlich isotherm ( = 10.021 mg/g, 1/n = 0.517) and it was established that the adsorption process is more accurately described by Langmuir model. It was detected that the equilibrium is established practically after 8 hours of the MB solution contacting with the tripod. In general, the kinetics of the MB adsorption process on tripol is described by the pseudo-two order kinetic model (к2 = 2.13  10-2 gh-1mg-1).