GISAP: Medical Science, Pharmacology

8-12

Authors: Lyudmila Telepneva

The origins of the nucleosome code are explained.

18-22

Authors: Lyudmila Telepneva

New schemes of activity of hemoglobin and the protein synthesis ribozyme are presented.

30-33

Authors: Alexandra Prokopyuk, Marina Knyazyeva, Tamara Pavlova

It was shown that ultrasonic, morphological and clinical-biochemical criteria can be used to assess the ovarian cancer (at late stages) neo-adjuvant polychemotherapy efficiency. The diagnostic complex and algorithm of the III-IV stage ovarian cancer treatment were introduced in this work.

38-39

Authors: Elena Krutskih, Lyudmila Bolotova, Tatyana Belous

The results of medical examinations of 37674 employees, carried out in hospitals of the Voronezh region are analyzed on the basis of study of final acts of periodical medical examinations, medical records and health certificates in the Center of Professional Pathology (CPP).

44-47

Authors: Igor Bugorkov

The work is devoted to the determination of market positions of medical institutions and enterprises at the dental services market with the purpose of increasing the efficiency of work of dental institutions of state and communal forms of property.

52-55

Authors: Andrey Korshunov, Igor Shestel, Michail Hamov , Sergey Markovskiy, Sergey Moskovskiy, Vladimir Konev

The purpose of the work: to study opportunities of application of atomic-force microscopy for morphological diagnostics of the pathology of the connecting tissue on firm tissues of teeth and bones. Materials and research methods: the analysis of the packing extent, size and form of bone plates, enamel prisms, size of an inter-prismatic interval and its height on 30 removed teeth and the bone tissue of persons with a connecting tissue dysplasia and 27 removed teeth and the bone tissue of a control group by the nuclear-power microscopy method. Results: research of a bone tissue and enamel of teeth is carried out in conditions of the connecting tissue pathology in comparison with patients without it. It was established that collagen configuration in conditions of the connecting tissue pathology assumes increase of an interval between fibers up to 98 nm which reduce the quantitative content of the mineral matrix in a bone. In enamel of teeth we have also determined violations of forms and sizes of enamel prisms (5.5х5.4 microns) with increasing distance between enamel prisms up to 1.6 micron. Conclusions: 1. Results of examination of the ultra-structure and mineral structure allow to talk about violation of mineralization and organization of enamel of teeth and the bone tissue of persons with the connecting tissue pathology symptoms. 2. Use of the nuclear-power microscopy allows to study native cellular cultures, including firm tissue of teeth and the bone tissue. 3. The specified facts can be used as a basis for the diagnostics of the connecting tissue pathology and for determination of individual characteristics in the process of identification of the personality.

61-63

Authors: Tamara Orlova

The biopharmaceutical investigation of suppositories of Paracetamol and Naproxen has been carried out by the Dissolution Test (Basket apparatus). Efficacy of the drug release has been studied depending on the type of the lipophilic base and the surface-active agents. Witepsol H-15 and Hard Fat including 1% phospholipid product are revealed to be the rational bases for production of Paracetamol or Naproxen suppositories. The analgesic effect of these active substances has been studied on the model of the chemical irritation by intra-abdominal acetic acid injection to white rats of the genesial age. The determined analgesic activity of Paracetamol or Naproxen suppositories (40 and 80% accordingly) was comparable to the intrastomach administration. The advantage of Witepsol H-15 over the Hard Fat (nonlauriс type) in realization of the antinociceptive effect of Paracetamol and Naproxen has been shown.