GISAP: Medical Science, Pharmacology

7-10

Authors: Natalya Markelova, Nikolay Khotko, Svetlana Medovschikova

A microbiological survey of 142 children admitted to the operative treatment in the center of cardiac surgery in Penza has been carried out. We studied colonization of the mucous membranes and the skin using conventionally-pathogenic microorganisms with identification of basic mechanisms of antibiotic resistance. Predisposing factors of carriage of resistant microorganisms were identified. This data formed the basis for the realization of preventive and control measures.

14-16

Authors: Rostyslav Pavliy, Svetlana Pavliy

Authors have investigated the sensitivity of methicillin-resistant Staphylococcus aureus extracted from patients with supurrative-inflammatory processes of various localizations to widely used drugs and to newly synthesized compounds of fluoren derivatives. The strains of staphylococci are most susceptible to fluoroquinolones (78,3-84,4%), cephalosporins (78,3-84%) and aminoglycosides 68,4-84,61%). Sensitivity of S. aureus to macropenes was negligible. The relatively high activity against the isolated strains of S. aureus has been shown by new derivatives of fluorene-Fl4, P6, P7 (63,0-70,79%). This is very important for their further study in order to develop new antimicrobial drugs.

24-26

Authors: Nazarbek Zhumanazarov

This author has reviewed 114 conclusions of forensic expert committees made in connection with the determination of the degree of the work capacity loss in the South-Kazakhstan branch of the forensic medical examination in 2000-2008. All of these examinations have been appointed by courts in connection with consideration of claims for damages caused to the health of applicants.

32-36

Authors: Ali Guliyev , Uckan Duygu Cetinkaya

Mesenchymal stem cell (MSC) are the important component of the microenvironment of the bone marrow and. Playing an active role in case of ineffective erythropoiesis they take part in regulation of erythropoiesis through the synthesis of cytokines. In the present study proliferative characteristics, morphology, phenotype and differentiation capacity of MSCs were examined. In addition, culture supernatants and bone marrow plasmas were analyzed for GDF 15.

40-41

Authors: Marina Knyazyeva

Biochemistry teaching in medical schools is one of the urgent problems of training doctors at present days. Discussion of this problem by lecturers of medical universities and academies on VIII-Х Ukrainian biochemistry conventions, on 29-35 FEBS Congresses in 2004-2010, on conferences concerning issues of clinical biochemistry has shown the absence of connection between the acquirement of theoretical knowledge in biochemistry and application of it in practical work of the doctor. That is why the traditional form of the biochemistry teaching needs significant improvement with the use of situational clinical tasks, obligatory implementation of the clinical biochemistry course and modern computer technologies on every teaching stage.

46-48

Authors: Ekaterina Baleva, Irina Krom

Authors consider quality of life as an assessment category of state of the subject in an illness situation. The results of author's research of quality of life relevant to health of patients with coronary heart disease are given in the article. Indicator of quality of the life, defined on the basis of a questionnaire of WHOQOL-100, supplementing an illness picture, is a multiple-factor criterion of assessment of the state of this category of patients.

53-55

Authors: Elibay Moldumarov

The article is devoted to modern methods of prosthesis of patients. The new innovative methods of diagnostics and treatment are mastered, materials of world-known producers are used. Specific examples of diseases and treatment of patients are provided.

8-12

Authors: Lyudmila Telepneva

The origins of the nucleosome code are explained.

18-22

Authors: Lyudmila Telepneva

New schemes of activity of hemoglobin and the protein synthesis ribozyme are presented.

30-33

Authors: Alexandra Prokopyuk, Marina Knyazyeva, Tamara Pavlova

It was shown that ultrasonic, morphological and clinical-biochemical criteria can be used to assess the ovarian cancer (at late stages) neo-adjuvant polychemotherapy efficiency. The diagnostic complex and algorithm of the III-IV stage ovarian cancer treatment were introduced in this work.

38-39

Authors: Elena Krutskih, Lyudmila Bolotova, Tatyana Belous

The results of medical examinations of 37674 employees, carried out in hospitals of the Voronezh region are analyzed on the basis of study of final acts of periodical medical examinations, medical records and health certificates in the Center of Professional Pathology (CPP).

44-47

Authors: Igor Bugorkov

The work is devoted to the determination of market positions of medical institutions and enterprises at the dental services market with the purpose of increasing the efficiency of work of dental institutions of state and communal forms of property.

52-55

Authors: Andrey Korshunov, Igor Shestel, Michail Hamov , Sergey Markovskiy, Sergey Moskovskiy, Vladimir Konev

The purpose of the work: to study opportunities of application of atomic-force microscopy for morphological diagnostics of the pathology of the connecting tissue on firm tissues of teeth and bones. Materials and research methods: the analysis of the packing extent, size and form of bone plates, enamel prisms, size of an inter-prismatic interval and its height on 30 removed teeth and the bone tissue of persons with a connecting tissue dysplasia and 27 removed teeth and the bone tissue of a control group by the nuclear-power microscopy method. Results: research of a bone tissue and enamel of teeth is carried out in conditions of the connecting tissue pathology in comparison with patients without it. It was established that collagen configuration in conditions of the connecting tissue pathology assumes increase of an interval between fibers up to 98 nm which reduce the quantitative content of the mineral matrix in a bone. In enamel of teeth we have also determined violations of forms and sizes of enamel prisms (5.5х5.4 microns) with increasing distance between enamel prisms up to 1.6 micron. Conclusions: 1. Results of examination of the ultra-structure and mineral structure allow to talk about violation of mineralization and organization of enamel of teeth and the bone tissue of persons with the connecting tissue pathology symptoms. 2. Use of the nuclear-power microscopy allows to study native cellular cultures, including firm tissue of teeth and the bone tissue. 3. The specified facts can be used as a basis for the diagnostics of the connecting tissue pathology and for determination of individual characteristics in the process of identification of the personality.

61-63

Authors: Tamara Orlova

The biopharmaceutical investigation of suppositories of Paracetamol and Naproxen has been carried out by the Dissolution Test (Basket apparatus). Efficacy of the drug release has been studied depending on the type of the lipophilic base and the surface-active agents. Witepsol H-15 and Hard Fat including 1% phospholipid product are revealed to be the rational bases for production of Paracetamol or Naproxen suppositories. The analgesic effect of these active substances has been studied on the model of the chemical irritation by intra-abdominal acetic acid injection to white rats of the genesial age. The determined analgesic activity of Paracetamol or Naproxen suppositories (40 and 80% accordingly) was comparable to the intrastomach administration. The advantage of Witepsol H-15 over the Hard Fat (nonlauriс type) in realization of the antinociceptive effect of Paracetamol and Naproxen has been shown.

7-10

Authors: Elena Panina, Inna Dorogova, Leonid Bartosh

The results of comparative analysis of pharmacotherapy of pregnant women with hypertension depending on the physicion`s speciality carried out in 2005-2006 and 2009-2010 are presented in this article.

14-17

Authors: Anastasija Vitavskaya, Hassan Hassiyev, Mayra Murzahmetova, Yeldos Izatullayev , Yuliya Pronina

The matter of influence of a new kind of grain bread "Whisk" (prepared without pressed yeast - from wholegrain coarse flour) on organisms of animals and humans is considered in the article. In acute experiments on rats it was revealed that introduction of the coarse flour bread to a standard vivarial diet significantly improves structural and functional characteristics of erythrocyte membranes and cells of internal organs of animals. Inhibition of lipid peroxidation of biological membranes of internal organs (liver, kidneys, heart, lungs and brain) occurs; red blood cell membranes permeability decreases; their peroxide resistance increases. Clinical trials have shown that the use of such product, enriched with dietary fibers, vitamins B, E, macro- and micronutrients enhances the binding of bile acids and removes them from the body. Total cholesterol level was significantly lowered from 6.39 ± 0,56 to 5,04 ± 0,46 mmol / l (?<0,05). This index of patients of the control group has not changed.

22-25

Authors: Elena Sorochan, Marina Stoykevich, Tatiana Tolstikova , Tatyana Boyko

The article is connected with the efficiency of «Calcium-D3 Nicomed» drug at treatment of osteopenia syndrome of patients suffering from ulcerative colitis and Crohn’s disease. Positive influence of the drug on the structural-functional state of bone tissue was confirmed with the help of ultrasound densitometry and examination of calcium-phosphoric metabolism.

28-31

Authors: Larisa Surkova, Ludmila Zaklyakova, Tatyana Shalayeva

To define the degree of affection of vessels an investigation of blood plasma of patients with type 1 diabetes (61 persons) and healthy donors living in Astrakhan region (24 persons) was carried out. The dependence of concentration of Endotheline-1 in blood plasma on the degree of affection of bloodstream of patients with diabetes was assessed.

37-41

Authors: Dmitriy Morozov , Elena Morozova, Faina Ratner

Hyperactive children cannot stay unnoticed. They always attract attention not only of their exhausted parents, angry teachers and doctors lifting their hands in dismay, but also of indifferent neighbors and surprised passersby as well as confused peers. These children are like elements, they could seldom be found resting; they are always on the go, something is “always happening to them”, they run, fidget, topple over things. Voluminous literature is devoted to them. They are the subject of the scientific research.

45-47

Authors: Elena Andrijanova, Elena Chernyshkova, Irina Krom, Irina Novichkova

Chronic noninfectious diseases are among the main causes of population's morbidity, disability and mortality in the majority of countries. The authors of the article consider disability as the way of personal socialization in a disease situation. Results of medical and sociological research focused on correlation of disability predictors allow to prove not-obligatory nature of clinical predictors in the socialization process of patients with chronic noninfectious diseases. Social and personal characteristics of a patient are obligatory in case when they are conditioned by premorbid and comorbid states in a disease situation as well as social resources for patient's socialization.

50-52

Authors: Aleksandr Ochkur, Alla Kovalyova, Anastasia Chuksina , Yana Kolesnik

Examination of the qualitative composition and quantitative content of organic acids of lipophilic extracts of Artemisia arenaria DC. herb has been performed by the method of chromatography-mass-spectrometry. In the current research 10 acids including 2 in the chloroformic extract and 10 in ethyl acetate-alcoholic extract were revealed.