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VIOLATIONS IN THE MENSTRUAL CYCLE AND CLIMACTERIC PERIOD OF WOMEN – AS RISK FACTORS OF HORMONAL BACKGROUND IN EMERGENCE AND DEVELOPMENT OF ONCOLOGICAL PATHOLOGY OF THE MAMMARY GLAND (BASED ON RESULTS OF THE SOCIOLOGICAL STUDY)
Authors: Dzvenyslava Moskvyak-Lesnyak, Vasyl' Ruden'
Number of views: 612
In the context of disturbances of the menstrual cycle and perimenopause among women (n=400/624, р<0,05) with a diagnosis of breast cancer (C50) and women of the control group (n=400/1335004, р<0,001) following risk factors for occurrence/development breast cancer pathology (C50) were determined: early – onset of menarche at age 10 years (1,00±0,50%, р <0,05), 11 years (5,75±1,16%, р<0,05), 12 years (13,25±1,70%, p>0,05) and late – at age 15 years (16,25±1,84%, р<0,01), 16 years (16,50±1,86%, р <0,01), 17 years (2,25±0,74%, p>0,05), 18 years (2,25±0,74%, p>0,05); duration of menstruation till one day (2,00±0,70%, р <0,05), one day (6,25±1,21%, p<0,01), during two days (17,25±1,89%, р<0,01), more than 5 days (16,25±1,84%, р>0,05); climacteric changes at age 22-30 years (2,10±0,52%, р<0,01), 31-41 years (25,63±2,32%, р<0,01), 42-58 years (59,24±3,48%, р<0,01), 59-70 years (13,03±1,08%, р<0,01), and the duration of climacteric process for 4-5 years (23,53±1,73%, р<0,01) and more than 5 years (45,38±2,22% , р <0,01). All this is confirmed by the multivariate analysis results.