GISAP: Medical Science, Pharmacology

3-6

Authors: Marina Chichkova, Natalya Kovalenko, Oleg Rubalskiy

In this article authors consider the influence of various immunological aspects on treatment of patients with the coronary artery disease. The detailed reviewing of the role of type 1 interferons has been carried out. The way of using anti-interferon antibodies as the diagnostic marker of the clinical flow of the metabolic syndrome and the coronary artery disease was offered.

11-13

Authors: Serik Abeldin

The work has the experimental nature. It has been applied on 10 outbred dogs. The analysis of results of the traditional treatment and erythrocitic pharmacocites in combination with surgical intervention into liver was made through examination of morphological, biochemical and ultra-structural changes of liver cells of experimental animals.

17-23

Authors: Sergery Kondrashev

Results of the research carried out have shown that there is a possibility of reproduction of platelets ex vivo upon condition of their placement in the suspending environment of the autoplasm or officinal additional solution for keeping platelets.

27-31

Authors: Andrey Korshunov, Igor Shestel, Sergey Moskovskiy, Viktoria Goloshubina, Vladimir Konev

The analysis of the morphological phenomena met during sectional observations of persons with a dysplasia of a connecting tissue is given. Authors underline inter-relations between the phenomena connected with a locomotorium and pathology of the skin and visceral organs. Recommendations concerning the analysis of morphological phenomena at dysplasia of the connecting tissue in the diagnostic aspect are given.

37-39

Authors: Boris Bezkaravaynyy, Marina Kogutnitska, Nataliya Yakovenko, Yevgen Sabadash

Postnatal adaptation of newborns is significantly supplied with hormones of fetoplacental complex and hypophysis-gonadal system. Interest to the problem of fetoplacental complex and hypophysis-gonadal system’s hormones’ influence on renal haemodynamics and reabsorption of sodium is caused by considerable oscillations of these hormones during pregnancy and early neonatal period. 106 newborn babies were investigated by us. Their levels of estriol, progesterone and prolactin were identified by radioimmunoassay. Premature babies are characterized by low level of fetoplacental complex and prolactin, slow elimination of these hormones from organism. This testifies to bad adaptation of ІІІ-ІV degree of prematurity. Deficiency of indicated hormones aggravates disorders of renal haemodynamics and osmoregulation of premature babies taking place at the background of morphofunctional renal immaturity and polyglandular neuroendocrinal insufficiency.

42-45

Authors: Elena Andrijanova, Irina Krom, Irina Novichkova, Tatyana Ilyina

The process of institutionalization of the medical and social work takes place in modern Russia nowadays. The aim of this process is the achievement of the greatest possible level of health and re-socialization of people being in difficult life situations. In the analysis of an institutionalization of medical and social work authors use the set of four functions (AGIL) presented by T. Parsons to characterize the social system. Functions and dysfunctions of medical and social work institute in Russia are considered on the basis of the Federal state institution of medico-social expertise taken as an example.

49-52

Authors: Andrey Korshunov, Ludmila Belskaya, RomanYeroshenko, Sergey Moskovskiy

In this work authors have studied the laboratory parameters of mixed saliva and the severity of the carious process of patients with parenchymal parotitis without complications and complicated by abscess formation in the parotid gland. More pronounced changes in the mixed saliva with severe caries process are observed at patients with an exacerbation of parenchymatous parotitis on the background of abscess formation. Adverse conditions associated with abscess formation, can be explained as a "vicious circle" in the form of violation of mineralizing and secretory functions of mixed saliva and poor oral hygiene, which is an additional source of infection.

3-7

Authors: Nina Bychkova , Oleg Bychkov, Taras Nykula, Valentyna Moyseyenko

The work includes data on quality of life of patients with arterial hypertension and associated osteoarthritis. The authors present the technique of diagnostics of a pain syndrome and disorders of functional activity intended to improve the prognosis of the disease and to increase lifetime, taking into account the cardiovascular system risk factors.

13-17

Authors: Lyudmila Telepneva

Origins of selection of proteinogenic amino acids and the genetic code are explained.

23-29

Authors: Vasyl' Ruden'

The results of study acquired in accordance with the developed sociological program “Man’s opinion of a Christian Lent (CL) as a spiritual and moral mean of a healthy way of life” convincingly testify that the CL is a verified mean for overcoming the Man’s own limitedness in stereotypes of own life. Besides, 81.4% of respondents consider the CL to be a remarkable health-improving mean for the body and the humility example for the spirit. At the same time, 94.73±1.66% respondents consider the CL as a spiritual mean for the human body able to correct the worldview on a current healthy way of life. 3.26±0.96% expressed the idea of its health-improving effect on the body and the soul through observance of rules of healthy living by the Man. All of this makes us think that the CL should be considered as an unused spiritual and moral reserve of public health in the independent Ukraine in the process of developing the basis of a healthy lifestyle. This will allow to strengthen spirituality and health, prolong life, improve social, economic and cultural level of the secularized society.

34-37

Authors: Boris Bezkaravaynyy, Elena Seroshtan, Galina Solovyova, Irina Climenko, Valery Dgastin Toyoem Foning

The authors present the results of a dynamic rheopneumographic monitoring of 155 premature infants with perinatal cerebral patology (82 newborns with hipoxic-ischemic CNS disorders and 63 newborns with hipoxic-hemorrhagic CNS disorders). Periodic breathing with respiratory pauses is shown by all patients, as well as the significantly longer duration of apnea among infants with hypoxic-hemorrhagic CNS lesions. An inverse correlation of medium strength between gestational age and the quantity of apnea during the day is revealed.

40-43

Authors: Elena Evdokimova, Lyudmila Bashkatova, Mohammed Ismail Haybek, Mustafa Huseyn Mohamed, Nataliia Gryshchenko

The authors examined an anemia symptom which is quiet often admitted in the pediatric practice and able to develop in cases of hematological and somatic pathology. Directions of differential diagnostics are shown. Special attention is paid to the iron deficiency anemia of children of older age groups and adolescents. Endoscopic peculiarities of upper gastrointestinal bleeding of children are described.

48-51

Authors: Elena Kondratenko, Natalia Lomteva

To examine the anxiolytic effect of the Nelumbo nucifera seed extract we studied the behavior of animals in conditions of the Suok-test. Our results indicate the expressed psychotropic effect of the Nelumbo nucifera seed extract.

56-60

Authors: Anastasiia Shuba, Igor Tyurkin, Tatiana Kuchmenko, Valeriia Bityukova

Authors discuss the possibility of increasing the rapidity and reliability of the sexually transmitted infections diagnosis by using an array of piezo-sensors for detection of gases-markers in the equilibrium gas phase above biomaterial and differentiation of pathogens.

64-65

Authors: Lena Baldanova, Olga Belykh

Useful plants of the kind Ranunculaceae Juss have been studied in terms of culture. Information about introduction in terms of Eastern Siberia collected throughout many years has been analyzed.

3-6

Authors: Elena Morozova, Svetlana Kashchenko, Vitaliy Morozov

Peculiarities of the Peyer’s patches in the small intestine of rats after correction of the cyclophosphamide-induced immuno-suppression with Imunofan were studied. It was discovered that leveling of cytostatic drug takes place by 30 days. This testifies to the effectiveness of use of Imunofan as the corrector.

11-13

Authors: Karlygash Sadykova, Murat Shegebaev, Zhanar Shalharova, Zhanat Shalharova

Nowadays questions of the contribution of genetic factors in the course of stomach ulcer are discussed. The research is focused on the determination of dependence of frequency of recurrence of stomach ulcer Gln27Glu polymorphism of ?-2-adrenergic receptor gene shown by people of Kazakh nationality suffering from the stomach ulcer. It is revealed, that patients with Gln27Gln polymorphism of ?-2 adrenoreceptor propensity gene show inclination to the recurrent course of peptic ulcer.

18-21

Authors: Aleksandr Babiy, Boris Shevchenko, Nikolay Shularenko

Authors analyze results of surgical treatment of uncomplicated cholecystolithiasis in the period of up to 5.2 years.

26-27

Authors: Lyudmila Kamishnikova, Olga Efremova

The research data concerning the application of atorvastatin for patients with chronic heart failure with different left ventricular ejection fractions are presented.

32-36

Authors: Taras Nykula, Valentyna Moyseyenko

The given work is devoted to the assessment of the endothelial dysfunction and immune system disorders shown by nephrological patients and also to the problem of increasing frequency of their occurrence in particular during the development of the chronic renal failure. According to the results the use of the technique of differential antygomotoxic therapy improves the efficiency of treatment of patients with chronic renal failure and helps curing affection of gastroduodenal zones.

42-44

Authors: Leonid Bartosh, Sergey Tuzov, Valery Tipikin, Vyacheslav Teljanov

The interrelation of arterial hypertension and the obstructive sleep apnea-hypopnea syndrome of women in the III trimester of pregnancy is considered.

48-49

Authors: Elena Bogorad-Kobelska

The author reviews main biological properties of derivatives of diphenyl. The author also presents the results that help to make a conclusion concerning mechanisms of action of compounds.

5-11

Authors: Dzvenyslava Moskvyak-Lesnyak, Vasyl' Ruden'

In the context of disturbances of the menstrual cycle and perimenopause among women (n=400/624, р<0,05) with a diagnosis of breast cancer (C50) and women of the control group (n=400/1335004, р<0,001) following risk factors for occurrence/development breast cancer pathology (C50) were determined: early – onset of menarche at age 10 years (1,00±0,50%, р <0,05), 11 years (5,75±1,16%, р<0,05), 12 years (13,25±1,70%, p>0,05) and late – at age 15 years (16,25±1,84%, р<0,01), 16 years (16,50±1,86%, р <0,01), 17 years (2,25±0,74%, p>0,05), 18 years (2,25±0,74%, p>0,05); duration of menstruation till one day (2,00±0,70%, р <0,05), one day (6,25±1,21%, p<0,01), during two days (17,25±1,89%, р<0,01), more than 5 days (16,25±1,84%, р>0,05); climacteric changes at age 22-30 years (2,10±0,52%, р<0,01), 31-41 years (25,63±2,32%, р<0,01), 42-58 years (59,24±3,48%, р<0,01), 59-70 years (13,03±1,08%, р<0,01), and the duration of climacteric process for 4-5 years (23,53±1,73%, р<0,01) and more than 5 years (45,38±2,22% , р <0,01). All this is confirmed by the multivariate analysis results.

18-24

Authors: Irina Koliada, Vasyl' Ruden'

.

30-32

Authors: Olena Krekoten

Some aspects of life style of employees of transport enterprises of different ownership forms have been studied using the sociological research method. Sampled selections of the main and control groups were formed. Their analysis provided verification of the suggested hypotheses. Comparative analysis was performed according to the criterion of the enterprise ownership form in two regions of the country. Dependence of the life style on social-economic and demographic factors have been determined.

36-37

Authors: Yuriy Lakhtin

The author has studied the degree of conditionality and assessment of power of cause-and-effect relation of emergence of parodontitis, dentoalveolar anomalies and teeth caries among people under the influence of salts of heavy metals in the environment. Relative and attributive risk of distribution of these illnesses is calculated.

41-44

Authors: Alexander Chiglintsev

The course of studying and statistic classification revealed that hereditary predilection and metabolic derangements in the organism determining disease initiation and development is the main causal complex of urolithiasis. All other factors cover necessary conditions to realize and release predetermined disease internal possibilities. Directed at metabolic derangements prevention and treatment activities are perspective in urolithiasis recurrence prevention.

48-49

Authors: Alexandr Guz, Sergei Jaitsev

Application of immunomodulating liniment Cycloferon in the complex chemoradiotherapy of oropharyngeal cancer allows to avoid the development of severe mucositis with erosive and ulcerative lesions and promotes non-specific resistance of the mucous of the mouth, which allows to complete therapy at the optimum time.

53-55

Authors: Danelina Vacheva

The purpose of the research is to examine, follow and report on the improvement of abilities to do daily and labor activities among patients with distal radius fracture in early and late post-immobilization period. Materials and methods: 106 patients who suffered from distal radius fracture were included in the study, they underwent a physio-rehabilitation program adjusted to each particular case which included sub-water gymnastics – local bath tub with water temperature 34-36° C, in the area of wrist joint and forearm, kinesitherapy, occupational therapy, impulse magnetic field – 15–20 min, 2 А, 1 – 100 Hz, interference currents – 5 min, 90 – 100 Hz ; 10 min 1 – 100 Hz, 10 procedures daily. Results and analysis: Comparative analysis of results shows that patients with injured non-dominant limbs have less difficulty in early post-immobilization period than patients with traumas in a dominant limb. In the end of the rehabilitation patients with injured dominant upper limbs have better test results. Conclusion: in order to get good results in rehabilitating patients with distal radius fracture and improving their self-service abilities the due beginning of the rehabilitation process and including labour therapy and everyday life activities in the form of guidelines are of utter importance. The functional labour therapy stimulates patients’ self-dependence and speeds up their return to professional and social activity.

59-60

Authors: Marina Buryak, Natalya Khokhlenkova

In this article physicochemical properties of the ointment based on thick oak bark extract and juice of Kalanchoe are studied. It was found that the total mass of water absorption of ointment was 342% - this proves good osmotic activity of the ointment. Also, it is necessary to note that the water absorption of ointment uniform and proportionate.

3-4

Authors: Norbert Borkach

Agenesis of Palmaris longus muscle is widely studied all over the world, and in recent years the frequency of researches and studies related to Palmaris longus muscle agenesis has rapidly increased. During the studies of Palmaris longus muscle different tests were applied by different authors. The aim of this study was to estimate the efficiency of most commonly used tests during the study of Palmaris longus muscle agenesis in population of Hungarian ethnic origin.

9-10

Authors: Yuriy Lakhtin

With the help of atomic absorption spectrophotometry the nature of heavy metals (Fe, Zn, Pb, Cu, Mn, Cr) accumulation in rat’s teeth enamel was studied. It was determined that in enamel of animals receiving salts of heavy metals the concentration of Zn potentially increased for 87.5%, Pb for 80.8%. There was a tendency for Fe increasing for 39.1%. At the same time the accumulation of Cu was for 57.8% less compared to control group, Cr content in enamel decreased for 30.9% and Mn for 25.7%. It was concluded that salt mixtures of Fe, Zn, Pb, Cu, Mn, Cr course mineral imbalance in teeth enamel. Dyscrasia of metals in enamel can be a risk factor of hard tooth tissues pathology.

14-15

Authors: Vera Vokina

Toluene is a major component of numerous commercial organic solvent formulations. We have investigated the effect of an inhalation exposure of 150 ppm for 4 weeks (4 h/day, 5 days/week), followed by a postexposure period of at least 4 weeks, on rat behavior in a Morris swim maze. Toluene-exposed rats showed significantly increased latency at the platform. Present results indicate that exposure to low concentrations of toluene leads to persistent effects on cognitive properties of the rat.

18-19

Authors: Shorena Vashadze

Many people suffer from depression and it’s commonly shown by people with epilepsy. Depression is the most frequent psychiatric disorder at epilepsy. The aim of the report is to learn depression factors shown by epileptic adults and their selfish mood; to analyze and to plan methods of the problem solution. Scientists consider that character of adults can changing gradually or spontaneously. Spontaneous changes may be brought by some psycho-traumatic factors caused by parental or pedagogical actions. Difficulties are mostly shown by called epileptic adults as the object of our research. We’ve asked 50 senior students from Batumi, Khelvachauri & Kobuleti. They are registered in different polyclinics and are systematically receiving medical treatment. They have epilepsy since childhood and have 5-10 year anamnesis of the disease. In critical situation a person perfectly shows all features of own character. 25 women and 25 men at the age of 16-60 were studied. According to Becki questionnaire it was possible to ascertain the depression quality. The questionnaire consists of 21 question. The depression quality: mild, medium and severe can be ascertained by this questionnaire. Among patients studied total absence of depression was shown by 3%, 17% have light depression, 30% have medium depression and 50% have comprehensive depression. Among them 65% are characterized by suicidal thoughts; 70% by bad mood, 45-45% have sexual and sleep disorders; 34% have a lack of appetite and 25% frequently cry. Among epileptic women low excitement degree was discovered at 14%, medium low degree - 13%, medium high - 50% and high level degree - 23%. Among men low level of excitement degree was discovered at 15%, medium low - 21%, medium high degree - 47% and high degree - 12% of men. Apathetic, unemotional adults are easily getting angry, ready for quarrels and calm down slowly (25%). The number of depressed students often having bad mood is noticeably low (12%). Depression related to psychological effects of living with epilepsy and other problems of life can be effectively treated in most cases by psychotherapy and consultations. Discussions of troublesome feelings with a psychiatrist or psychologist can be extremely helpful. The research made it obvious that epileptic adult depression and selfish attitude towards surroundings is widespread. Such people need psycho-social rehabilitation, problem searching and solving. All this must be combined with antiepileptic drugs.

25-26

Authors: Elvira Gabbasova, Viktor Derecha

Authors consider features of personal reactions of patients on consequences of the myocardial infarction and problems of improvement of their recovery and adaptive potential, harmonization of controlling behavioural strategies, application (for this purpose) of psychotherapeutic methods and special trainings under control of biological connection with an electroencephalography.

30-33

Authors: Konstantin Yetsko, Yuliana Fornea

Education improvement process in a medicine university was oriented on realization of the systematic approach for revealing modern trends of professional pedagogical competences development. Since 2008, major changes occurred in pedagogic and methodological preparation and qualifications of the Nicolae Testemitanu State University of Medicine and Pharmacy professors. We qualitatively changed the formation of pedagogic competences and the culture of evaluation activity of the medical university professors (about 200 persons). Significant place in pedagogic preparation of the medical university professors is occupied by the education qualitology, psychology and pedagogy of higher education, mastering the wide range of the pedagogic methods and strategies which increase the quality of the future doctor’s education.

38-41

Authors: Elivira Rumyantseva, Natasha Kotova

Authors present the assessment of postural control of children with children's cerebral palsy of various physical before and after classes within the author's program with the use of a stabilometry method.

45-51

Authors: Vasyl' Ruden'

The author emphasizes the overcoming of stereotypes in clinical thinking of doctors: from the diagnostic and treatment process of the breast cancer (C50) to its epidemiological principles – risk factors in development this disease (C50). In this regard the author has worked out organizational and functional model of management of risk factors related to development of the women's breast cancer (C50) - as the basis of the family doctor's preventive activity in conditions of reformation of medical sphere in the independent Ukraine.

56-58

Authors: Elena Krylova, Larisa Demeshkina, Yuriy Stepanov

This articles is connected with issues of life quality of patients with chronic pancreatitis. The specific questionnaire aimed at examination of life quality of patients with this disease in the treatment dynamics was worked out. The assessment of easiness of perception and understanding of questions of the specially developed life-quality questionnaire and comprehensiveness (time needed to fill it in) was explored.

62-65

Authors: Marina Chichkova

Every year in Russia 1 million and 300 thousand people die of cardiovascular diseases. The coronary heart disease (CHD) (51-57%) and sharp violations of brain blood circulation (21-31%) are the main reasons for that. General incidence of cardiovascular diseases in the Russian Federation tends to growth.

68-70

Authors: Aleksandr Ochkur, Andrey Komissarenko, Nikolay Komissarenko, Yulia Avidzba

For achievement of maximum efficiency and safety of treatment of diseases (in particular the hypertensive illness (HI) and insomnia), combinations of drugs must be mutually complementary. In this case their pharmacological properties strengthen. Also in this case the risk of development of complications (mostly on heart, kidneys, vessels, brain [6, 7]) considerably decreases.

74-78

Authors: Beket Kazbekov, Zhanat Kazbekova

Authors present a comprehensive analysis of development of the pharmaceutical industry in Kazakhstan. Difficulties and problems that have emerged in the course of organizational and economic reforms in the industry are revealed. Measures including organizational and methodological steps allowing to eliminate barriers in development of the pharmaceutical industry are offered.

80-82

Authors: Alla Kovalyova, Tatyana Ilyina, Yana Kolesnik

Genus dead-nettle (Lamium L.) is most widely presented in a mint family (Labiatae). More then 40 of its kinds grow in the territory of Ukraine. Representatives of the genus Lamium are perennial (rarely annual), rhizome grassy plants - semi-bushes and bushes 30-60 cm high with creeping horizontal rhizomes developing into long underground sprouts.

86-89

Authors: Amir Alzhanov, Vladilen Polyakov

Joint researches of the North Kazakhstan State University and JSC International scientific and industrial holding "Phytochemistry" are presented in article. Studies are devoted to examination of a chemical composition of vegetable raw materials of the Republic of Kazakhstan for the purpose of application of drugs received from it in the field of medicine and agriculture. From buds of a balsam poplar a number of effective drugs (not worse and sometimes even more effective then drugs used in practice) is received. The substance "Topolin" (an intermediate product with the outlet of ~ 35%) was obtained in a barothermic way without the use of organic solvents (alcohol, benzene, acetone, ether). Further, on the basis of the substance the following drugs was received: alcohol tincture (for treatment of the periodontal disease, stomatitis), ointment (mycosis, streptoderma), essential oil, medicinal cigarettes (tuberculosis), suppositories (colpitis, erosion, prostatitis), chewing gum (mouth inflammation), fibrinous films (new bandaging material for surgery), food (protection of the haematogenic system against ionizing radiation; applicable in oncology at radiation of oncological patients).

93-95

Authors: Alla Kovalyova, Nataliya Yurchenko, Tatyana Ilyina

Examination of qualitative composition and quantitative content of fatty acids of the spreading bedstraw (Asperula humifusa (M.B.) Bess.) was carried out by the chromato-mass spectrometry method. As a result of the research 16 fatty acids, including 9 saturated (37,45% of all fatty acids) and 7 non-saturated (62,55%) have been revealed. Dominating components are palmitic, linoleic, oleic and linolenic acids.