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Study of endometrial pathology in cases of abnormal uterine bleeding – A Meta analysis of 435 cases.
Authors: Sandhya Panjeta Gulia, M.Lavanya, Madhusudan Chaudhury, SP Arun Kumar
Number of views: 284
Abnormal uterine bleeding is a common cause for women of all ages to consult their physicians. The specific
diagnostic approach depends whether the patient is premenopausal, perimenopausal or postmenopausal. Hence
hormonal therapy, endometrial biopsy, hysterectomy or imaging studies can be done accordingly. Retrospective
analysis of endometrial biopsies to find out the spectrum of causes of abnormal uterine bleeding in different age
groups. A total of 435 cases of endometrial biopsies were examined during a three year study period from Jan 2010
- Dec 2012 was examined. Serial sections, 3 – 5 μ were stained with Haematoxylin & Eosin (H&E) stain. 156
endometrial biopsies obtained by dilatation and curettage and 279 cases from hysterectomy specimens were
reported. The majority of cases of AUB were noted in perimenopausal age group constituting 258(59.31%) of total
cases, the rest being reproductive age 146(33.56%) and postmenopausal 31(7.13%) age group. The most common
pattern was normal cyclic endometrium in 200(45.48%) cases, disordered proliferative endometrium in
56(12.88%), hormonal effect 16(3.68%), endometrial polyp 10( 2.30%), endometrial hyperplasia 73(16.78%),
endometrial stromal tumor 1(0.23%), endometrial carcinoma 5(1.15%) , gestational endometrium 41(9.43%),
vesicular mole5(1.15%), irregular ripening 3(0.69%), irregular shedding 1(0.23%), chronic endometritis 6(1.38%),
atrophic endometrium 17(3.91%) , inadequate biopsy 1(0.23%). The study of endometrial biopsies helps to evaluate
the cause of abnormal uterine bleeding, thus helps the clinician to guide for appropriate therapeutic intervention.