Journal of Medical Science and Technology

3 -8

Authors: Rama Krishna Reddy Y V , Sushma Reddy V, Amar Nagesh Kumar, Sai Krsihna

Aim: To know the leading cause for diabetic retinopathy using simple serological parameters. Materials and methods: Diabetic patients of age 38-70 with retinopathy were taken as cases and age matched healthy individuals with age of 37-69 was taken as controls for this study. Fasting and postprandial blood samples were collected for analyzing BG, HbA1C, Lipid parameters, MDA and Vitamin-C. SPSS Software 17 was used for statistical analysis. Results: The results of cases were compared with a control, shows highly significance for each parameter. Vitamin C showed significant negative correlation with the LDL and MDA. The LDL showed a significant positive correlation with HbA1C and MDA. TC and LDL showed significant positive correlation with MDA and Significant Negative correlation with the Vitamin-C. Conclusion: Hyperglycemia is the cause for glycosylation which independently provokes lipid peroxidation by decreasing the antioxidant status that neutralize free radicals, so it is the glycosylation and lipid peroxidation plays a main role in the development of retinopathy in diabetes mellitus.