Environment&Health (Dovkillia ta zdorovia)

4-9

Authors: Пятница-Горпинченко Н.К.

Objectives - generalization of the results of scientific studies on the regularities of asbestos (fiber) carcinogenesis, definition of the prior problems that require further study. Materials and methods. We performed the analytical review of the published scientific papers, including abstract databases “PubMed” [http:www.ncbi.nlm.nih.gov/pubmed]. Results of studies and their discussion. We established that asbestos cancer potential was associated with the production of free oxygen and NO-radicals, with active forms of iron. Conclusions. Further study of the regularities of the blastomogenic effect of asbestos with the use of the experimental models of synthetic asbestos, including studies on the biological properties of fibers with the modified structure, refinement of the contribution of other industrial and non-industrial factors in the formation of asbestos-related cancer is one of the prior directions in the decrease of the cancer hazard of this mineral.

14-17

Authors: Єрем Т.В., Єрем Х.В.

Objective. We analyzed a hygienic state of various water supply source s and its impact on the formation of stomatologic pathology in the population of Zakarpattia. Materials and methods. The following methods for water survey: epidemiological, instrumental, and laboratory, sanitary-chemical and mathematical- statistical processing of study results were used in the study. Results: a problem of the formation of stomatologic pathology was considered, a role of the objects for water supply of the population of the Zakarpattia was determined. Conclusions: We determined the impact of natural -and - anthropogenic factor on the functioning of water ecosystems, it poses an ecological hazard not only for their development, but also for the existence of the man. We demonstrated the presence of direct correlative links between the state of water supply objects and stomatologic morbidity among the locals. “Content of iron in the water” - r=0,30 (p<0,05), “nitrites in the water” - r=0,36 (p<0,05), as well as "a state of the municipal water supply and open basins” - r=0,35 (p<0,05) belong to the most significant anthropogenic factors that cause the deterioration of the state of stomatologic health.

22-26

Authors: Петренко О.Д., Мельниченко Т.

Purpose of this work is a quantitative determination of the content of iodine and selenium in the saltwater fish and products and estimation of the experimental findings. Samples of saltwater fish, saltwater products and products from them were selected in the trade shops of Kyiv and the Kyiv region. A special attention was paid to the kinds of fish consumed by the population more frequent according to the data of statistical research.For the quantitative analysis of iodine and selenium, an inverse voltamperemetry by a three-electrode chart was used. Mass part of iodine in the seawater products was determined with the help of voltamperemetric analyzer "EKOTEST-VA", and selenium mass part - voltamperemetric analyzer "AVA-3". In accordance with the research results, the considerable discordances in the content of iodine and selenium was determined in the samples of fish and saltwater products, selected in the different points of retail trade. Considerable discordances of the obtained findings with the calculated indices were revealed. Compliance with the conditions of the storage of the frozen products in the trade shops, type of culinary treatment and introduction of the enriching additives (for example, iodine-treated salt) affects the content of iodine and selenium most of all. Sea algae are the most reliable source of iodine and selenium from the seawater products, they have rather high level of microelements even after culinary treatment.

33-37

Authors: Баленко Н.В., Черниченко О., Цимбалюк С.Н., Гульчій М.В., Баглій А., Федоренко З.П., Осташ О.М.

Objective. To clarify a potential influence of other environmental factors, except generally accepted - iodine deficiency and radiation, on thyroid cancer (TC) incidence. Results. Analysis of the literature revealed some peculiarities of the increase of thyroid cancer (increase of thyroid cancer incidence long before the Chоrnobyl accident; a parallel increase of cancer and precancerous incidence of ecology dependent nodular thyroid diseases (nodular goiter, autoimmune thyroiditis etc.); growth of thyroid cancer incidence in the areas not related to the territories suffered from the accident at the Chоrnobyl NPP and not related to the endemic by goiter) which allow, in our opinion, to suppose the influence of other environmental factors. Study of thyroid cancer incidence dynamics in Ukraine (1991-2011) according to the National Cancer Registry confirmed our assumption. It was established that the distribution of thyroid cancer incidence depended on socio-economic characteristics of the region. Higher levels of thyroid cancer frequency were registered in industrial and agricultural areas, it may be connected with aetio-pathogenetic role of anthropogenic contamination of environment including applying pesticides. Obtained data confirm a necessity of further thorough research on these issues.

42-45

Authors: азуляк Т.С., Кузьмінов О.Б.

In conditions of production of medicines on the basis of a dimedrol (diphenhydramine hydrochloride), the substance can get to air of a working zone. Important action which prevents harmful effects of chemical compounds on the health of workers is control compliance of the levels air pollution to the established hygienic regulations. Objective of research: development of the method of measuring the mass concentration of dimedrol in the working zone airResults. The photometric method of measuring the mass concentration of dimedrol in the working zone air is developed. Methodology is based on the capabilities of dimedrolum to form the yellow associate of as a result of cooperating with acid dye bromothymol blue at pH 4.6 with subsequent extraction of well-educated connection in a chloroform and measuring of absorbancy of the got solutions. A range of measured concentration 0.1-0.5 mg/m3. A lower limit of a substance in the solution volume is 10 mkg. A lower limit of measuring in the air (at selection 60 dm3 of air) is 0.1 mg/m3. The limit of a total relative mistake (± d at Р=0,95) does not exceed 25%.

50-55

Authors: Рубцов Р.В.

Objective of the work. To study the dynamics of cardiovascular hemodynamics indices of the mining industry workers having chronic obstructive pulmonary lung diseases of the professional etiology in the post-contact period with a help of echocardiography for timely detection of the violations of the stroke ability of heart and blood flow in great vessels, the development of both appropriate and effective treatment and prophylaxis of disease. Research methods. Echocardiographic examination of the mining industry workers who suffer from chronic obstructive pulmonary lung diseases of the professional etiology in post-contact period with the determination of the main linear and volumetric indices of the left and the right heart compartments, calculation indices that characterize the stroke ability of the heart of the hemodynamics in great vessels in different periods after stoppage of the work in the unhealthy production conditions. Results of the work. We determined that this category of the patients had the increased linear and volumetric indices of the left and right heart compartments, accompanied by a simultaneous decrease of stroke volume of the left and right ventricles and the right atrium. Revealed changes reach their maximum in the group of the workers with post-contact period of more than 10 years. At the same time, a significant decrease of conduction volume of the right ventricle and its contribution to stroke volume is observed in this group of workers, corroborating the issue on a deterioration of the stroke ability of heart in this category of patients. Vascular hemodynamics is characterized by gradual increase in the total peripheral vascular resistance which is the highest in the workers with post-contact period of 5-10 years and the specific peripheral vascular resistance, which highest indices are in the persons of this group of patients. Intrapulmonary hemodynamics is characterized by gradual increase of total pulmonary resistance, which highest indices are in the group of workers with post-retiring period (more than 10 years). It testified about formation and subsequent progress of pulmonary hypertension as one of the features of cardiopulmonary failure that occurs and progresses among the workers of mining industry who suffer from chronic obstructive pulmonary lung diseases of the professional etiology after stoppage of the work under unhealthy conditions.

64-69

Authors: Шенцова М.А., Сурмашева Е.В.

A unified system of the evaluation of probiotic preparations is presented in the part II of the article. Staged assessment of the preparations in vitro and in vivo experiments on the laboratory animals and in clinical trials were adopted. Data on the possibility of the adverse reactions which can cause probiotic preparations are presented. Development of new technologies for the production of probiotic preparations should be regulated by the relevant international rules both at the stages of laboratory (GLP), clinical trials (GCP), and at the stage of production (GMP). Biological objects can't be characterized only by chemical, physical-chemical or physical quantities. To define the main characteristics of medical immunobiological drug, its specific activity and microbiological indicators is possible only by means of the comparison with the same indicators standardized by the samples for comparison. The requirements to the standard reference samples - reference test-strains of microorganisms were discussed, they should ensure a stable specific activity.