International Journal of Pharmaceutical Chemistry and Analysis
Authors: Sonali P. Mahaparale, Vikas Gaware.
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Transdermal route of administration of drug is effective route of administration for different kind of indications. The purpose of present investigation was to develop Lornoxicam emulgel for systemic effect and to avoid side effects and minimize frequency of administration. Lornoxicam (NSAIDS) is a cox-1 and cox-2 inhibitor used in the treatment of pain, inflammations rheumatoid arthritis. Emulgel of lornoxicam was formulated using triethanolamine (5%) as solvent, carbopol 934 and carbopol 940 as gelling agents and various preservatives formulated gel was evaluated with respect to different physiochemical parameters such as ph, viscosity, Spreadability % drug content. All the prepared emulgel showed acceptable physical properties like homogeneity, colour, consistency, ph value, Grittiness, Spreadability, Extrudability % drug content. The results of in vitro drug release showed that carbopol 940 (0.4 gm) based emulgel gave better release. Also it was found that the gelling agent concentration had the most pronounced effect on the drug release from the emulgel.