The aim of this paper is to study the relativity between oxidative stress and cervical squamous cell carcinoma (CSCC) . Cervical cancer and healthy crowd cervical tissue were collected, and their content of Peroxiredoxin 6 (PRDX6) was measured and compared with Western Blot. PRDX6 was highly expressed in human CSCC tissue compared with healthy control, indicating that PRDX6 is a sensitive oxidative stress factor for the detection of cervical cancer.