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Immunological Reactivity and Nonspecific Resistance in Children with Hearing Loss Depending on Genes' Polymorphic Variants CJB2 (C.35DELG) and IL-4 (C-590T)
Authors: Oksana M. Iftoda, Larysa P. Sydorchuk, Oksana V. Kushnir, Yulia V. Repchuk
Number of views: 452
The general and cellular immunological reactivity and nonspecific resistance in 102 children of Bukovina region (Western Ukraine) with conductive or sensorineural deafness / hearing loss (CHL, SNHL), aged from 8 to 18 years, depending on the polymorphic variants of genes CJB2 (c.35delG) and IL-4 (C- 590T) were analyzed. General immunological reactivity in children with CHL 35delG-genotype carriers of CJB2 gene is characterized by higher humoral activity; cell immunological reactivity in CHL persons didn't depend on the CJB2 and IL-4 genes' genotypes. Endogenous intoxication prevails in 35delG-genotype carriers of CJB2 gene vs Non-del carriers, more in CHL than SNHL children - by 9.72 %; exogenous intoxication of infectious origin is present and higher significantly in CHL children with 35delG genotype of GJβ2 gene and TT genotype of the IL-4 gene. The manifestations of infectious inflammation in CHL persons with TT genotype of the gene IL-4 associated with lower humoral immunity activity 2,01-3,46 times, and testified the predominance of macrophage defense mechanisms over microphage, lower general reactivity, propensity for primary chronic course of disease. The general immunological reactivity changes in SNHL children depending on the gene IL-4 genotypes were not established.