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The Monitoring Features Under Eosinophilic Phenotype of Bronchial Asthma Among the Children
Authors: Tatiana Bilous, Vladymyr Bilous
Number of views: 378
Purpose: to study features of monitoring in the dynamics of the basic treatment of eosinophilic phenotype of asthma in school-age children.
Materials and methods. Surveyed 88 school-age children with bronchial asthma. The first group included 45 patients who met eosinophilic phenotype (EFBA) and group II formed the 43 patients with evidence of neutrophilic phenotype (NFBA).
Results and discussion. It should be noted that if the early inflammatory therapy destination exchange only 10.5% of the patients disease was defined as EFBA controlled and the finishing treatment increased the proportion of cases of controlled to 25.6% (Pφ>0,05) and in the second clinical group – at 22.3% of 50.0% patients, Pφ<0,05. Also marked anti-inflammatory effect in both groups in exhaled breath condensate and increase in the lability of the bronchi occurred in 39.1% of children with EFBA, and 60.0% of the representatives of the comparison group.
Conclusions. Thus, in patients with signs of eosinophilic phenotype compared with children with neutrophilic airway inflammation markers hyperresponsiveness and inflammation of the bronchi more expressive as the lability of the respiratory tract. Under the influence of the basic anti-inflammatory treatment in patients with eosinophilic asthma phenotype is a reduction of inflammation of the bronchi, but not lability and hyperresponsiveness.