European Journal of Medicine. Series B

4-9

Authors: Maradi A. Burduli

The paper presents the research results achieved by creating a model of experimental pulpitis model and the influence of drugs. For the exposure there is used the propolis and retabolil. Based on data from their experimental research, it can be concluded that in the pulp chamber, the creation of the experimental pulpit model, cells of the connective tissue from the stable state were removed, and by the action of biologically active substances – propolis and retabolil – there were created conditions like gonads. As a result, division and differentiation of the cells were obtained by the figures of meiosis. Therefore, when two haploid single-cell cells of one organism merge, a zidopod-like cell will be obtained, which will be capable of (can be able to) develop and give rise to cellular populations.

16-22

Authors: Sergey A. Sherstyuk, Svitlana A. Nakonechna, Maryna O. Ivanenko

There was studied the influence of neonols AF 9-12 and AFS 9-6 KM on parameters receptor connection of adrenal, serotoninal, dofaminal and glucocorticoid receptors of celebral cortex in subacute toxicological experiment on white rats Vistar population, that were exposed to 45 days feeding in dozes 1/100 and 1/1000 DL50. The revealed alterations on the part of 1-adrenoreceptors were characterized by inerese of affinity to lygand and decrease of number of this type of receptors. There was observed the increase of number of highly afinal and decrease of low afinal pool -adrenoreceptors in experimental groups of animals. The parameters of connection of serotoninal receptors of second type were chanding in affinity of connection with lygand. In animals of experimental groups were changed affinity D2-receptors to the marked lygand in cortex in comparison with control. Xenobiotics inereased the presence of glucocorticoid receptors in celebral cortex.

30-58

Authors: Evgenii D. Adamovich, Pavel L. Alexandrov, Oleg V. Gradov

This paper provides a new approach for ion channels activity registration in noisy conditions with stochastic incoherent open-close transitions on membranes. The required result is obtained using phase-selective nanovoltmetric techniques with frequency discrimination. This technical principle is the foundation for different phase-selective (φ-path-clamp) methods, based on vector voltmeters or lock-in nanovoltmeters for indication of the real and imaginary components of the complex electrophysiological signals in the ion channel activity.