INTERNATIONAL JOURNAL OF ANATOMY PHYSIOLOGY AND BIOCHEMISTRY

5-13

Authors: DR. PAGAR ATISH B, DR. RAUT SAYALI E.

Molecular motors are essential agents of movements in living organisms, harnessing chemical free energy released by hydrolysis of ATP, belong to the same protein family, the P-loop NTPases. In terms of energetic efficiency, they can be superior to man-made motors. They operate by small increments, converting changes in protein conformation into directed motion. Key words: ATP, Dynein, Kinesin, Motor, Molecular Motor, Myosin, P-loop NTPases

18-21

Authors: DR. WARE SANDHYA S, DR. NAGARGOJE PRAVIN P, DR. PHAD VAIBHAV V, DR. SAWAITULDR VINOD K

Pre-eclampsia is a disorder of pregnancy characterized by hypertension and proteinuria. It is now thought that abnormal placentation and placenta function is a strong predisposing factor for pre-eclampsia. Syncytial knots are aggregates of nuclei at the surface of terminal villi and their number increase with increasing gestational age. Increased syncytial knots (Tenny parker change) are associated with conditions of utero-placental malperfusion and are important in placental examination. Vasculo-syncytial membrane (VSM) is the primary site of feto-maternal exchange in placenta. In pre-eclampsia, VSM thickness is increased causing fetal hypoxia. We here report a case of an autopsy finding in a pre-eclamptic female. On histopathological examination, we found terminal chorionic villi with excessive syncytial knots (Tenny Parker change). Syncytial knots were seen in more than 40% of chorionic villi. Vasculo-syncytial membrane (VSM) thickness was also increased. Thus, histopathological findings of Tenny Parker change and increased vasculo-syncytial membrane (VSM) thickness are the clues for placental pathology in pre-eclampsia. Key words: pre-eclampsia, placenta, syncytial knots, Tenny Parker change, vasculosyncytial membrane