INTERNATIONAL JOURNAL OF ANATOMY PHYSIOLOGY AND BIOCHEMISTRY

6-11

Authors: DR. HASHMI INTKHAB C., DR. WANKHEDE HARISH A.

Background: Hepatic tissue made from stem cells holds the promise of an unlimited source of material for transplantation. Liver is one of the organs working without a resting phase. Understanding the molecular mechanism governing liver development will also be valuable for efforts to differentiate therapeutically useful hepatic tissue from stem cells. Aim of study: To correlate body weight, liver weight, crown-rump length with gestational ages and to study microscopic structure of liver at various gestational age groups. Materials and method: Forty human fetuses (19 males and 21 females) of different gestational ages ranging from 12th to 36th gestational weeks were procured for the research work. Result: High correlation between body weight and gestational age of fetus. The Crown-rump length (CRL) showed gradual increase from 12th to 36th weeks of gestation. Highly significant correlation found between liver weight and gestational age of fetus. The percentage relative weight was variable throughout the period of the gestation. Microscopy shows haemopoiesis was abundant at early stages of gestation and decrease as the age of liver advances from 12th to 36th week of gestation. Connective tissue elements increase from 12th week onwards showing thick capsule and thickened trabeculae. Central vein appears at around 16th to 17th weeks of gestation. Branches of portal vein, hepatic artery and bile ductile appear later during development at about 18th week of gestation. Conclusion: All physical parameters showed gradual increase from 12th week to 36th week of gestation. The haemopoietic tissue was found abundant in early stage. Central vein, portal tracts appeared at around 15th to 18th weeks of gestation. Key words: Liver, hepatic tissue, portal triad, central vein, haemopoesis

16-20

Authors: Dhokikar GD, Birla VH, Ingale PW, Bende SP, Kadam PS.

Background - Preeclampsia is defined as the triad of hypertension, proteinuria and edema occurring after 20 weeks gestation in a previously normotensive woman. It is specific to human pregnancy and complicate 6 – 8 % of gestation after week 20. Preeclampsia is still one of the leading causes of maternal and fetal morbidity and mortality. Since the electrolytes sodium and potassium contribute significantly in the functioning of the vascular smooth muscles, the present study was designed to evaluate their role in the preeclampsia and compare it with that of normotensive pregnant controls. Material & Methods: In this case-control study serum electrolyte status was investigated in two groups: one with newly diagnosed cases of preeclampsia PE (n = 50) and the other of healthy primigravida as controls (n = 50) of same gestational age. Serum sodium and serum potassium levels were measured. Data was analyzed by Students Unpaired t test. Results demonstrated that difference for serum electrolytes, for sodium and potassium between cases (mean 138 ± 4.03 mEq/L, mean 4.0 ± 0.5 mEq/L) & controls (mean 137 ± 6.52 mEq/L, mean 3.9 ± 0.312 mEq/L) respectively, were not statistically significant (P value >0.05). Conclusion- we do not found significant difference in the Serum electrolyte status i.e. serum sodium and serum potassium levels in preeclampsia patients and normotensive controls. Key words: Serum electrolytes, serum sodium, serum potassium,Preeclampsia.