Indian Journal of Pharmacy and Pharmacology

1-5

Authors: Mallikarjun B Katte, Jagadishchandra S Ratnakar, Lopamudra Banerjee.

It was reported that some 3-amino 2-aryl-1-azolyl-2-butanol have antifungal effects. To understand the structural basis for antifungal activity and guide in the design of more potent agents, we performed quantitative structure activity. The Minimum Inhibitory Concentration (MIC) values of 3-amino-2-aryl-1-azolyl-2-butanol on yeast exhibited a strong correlation with the prediction made by the model developed in the present study. The statistical results of the Training Set, Regression coefficient r (0.841648) and r2 (0.708371) values gave reliability to the prediction of inhibitory activity of a series of Azole derivatives.

10-15

Authors: Anju Madhwar, Dharmender Gupta, Sujata Singh, N. A. Ansari

Objective: To determine the drug utilization pattern of antihypertensive agents in patients of hypertensive nephropathy in a tertiary care teaching hospital. Materials and Methods: This was a prospective observational study carried out in Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, over a period of three months. A total of 60 patients aged 40-79 years taking treatment for hypertension with associated nephropathy were enrolled in the study. All the relevant data were collected and drug utilization pattern of antihypertensive agents was determined. The study evaluated the percentage of use of multidrug therapy, drugs prescribed from Essential Drug List (EDL) and prescriptions with generic name. The cost of antihypertensive drugs used per day was calculated and linked with socioeconomic status of the patients. Results: Evaluation of the prescriptions demonstrates that a total of 63.3% males and 36.7% females with mean age of 58.9±11.9 years were enrolled out of which 70% patients were on multidrug therapy while only 30% were on monotherapy. The most common drug prescribed was amlodipine and around 60% drugs were from EDL 2011. Though only 16.67% patients were prescribed generic drugs but it did not affect the economic condition of the patient as most of enrolled patients belong to upper middle class. Conclusion: The prescriptions analysed were in accordance to guidelines of JNC-8 (Joint National Committee – 8) and most of the prescriptions were found to be rational and it also shows that management of hypertensive nephropathy needs combination therapy.

21-26

Authors: A. P. Dewani, D. S. Mohale, S. Hiware, R. L. Bakal, A. V. Chandewar

This work is concerned with application of simple, accurate, precise and highly selective reverse phase high performance liquid chromatographic (RP-HPLC) method for simultaneous estimation of Niacin (NA) and Simvastatin (SIM) in combined dosage form. Chromatographic separation was achieved by isocratic mode using a reverse phase C18 column (phenomenx, 150 х 4.6 mm i.d.). The mobile phase composed methanol:water in ratio 85:15 water consisting of Triethylamine (TEA) (0.05%v/v) v/v at flow rate of 1 ml/min pH was adjusted to 4 with orthophosporic acid. Detection was carried out using a UV-vis detector at 250 nm. The mean retention time of NA and SIM was found to be 1.8 min and 8.5 min. respectively. The method was found to be linear in the range of 80-120 μg/ml with mean recovery of 99.39% for NA and 99.18% for SIM. The correlation coefficients for both NA and SIM were close to 1. The developed method was validated according to ICH guidelines and values of accuracy, precision and other statistical analysis were found to be in good accordance with the prescribed values. Thus the proposed method was successfully applied for simultaneous determination of NA and SIM in routine analysis of formulation.

43-54

Authors: Hariprasad M .G, Rema Razdan, Yash T. C

Objectives: Anti-neoplastic drugs like Cisplatin, Taxols are associated with the development of peripheral neuropathy (PN). Severe neuropathy can occur in 3% to 7% of treated cases with single agents but can increase to 38% with combined regimens. The treatment options for PN currently include anti-depressants, anti-convulsants and opioid analgesics. These agents are modestly effective for symptomatic relief, but they do not affect the underlying pathology nor do they slow progression of the disease. Therefore, effective treatment for chemotherapy induced neuropathy would be a major advantage for cancer patients. It is well established thyroid hormones lays an important role in regulating the development and regeneration of the nervous system & local administration of triiodothyronine (T3) at the level of transected rat sciatic nerve increased the number and diameter of regenerated axons and SCG10 protein levels about two-fold in the different segments of transected nerve during the regeneration period.SCG10 protein is a regulator of microtubule dynamics in growth cones. The main objective of the study was to evaluate the neuroprotective activity of thyroxine in Cisplatin-induced PN in rats. Methods: PN was induced by Cisplatin - 2mg/kg,i.p. twice weekly for 8 weeks. The degree of protection was determined by measuring electrophysiological properties of sciatic nerve like nerve conduction velocity, motor in-coordination, thermal &cold hyperalgesia, grip strength and histopathological studies. Results: PN was evidenced in Cisplatin control rats and ameliorated with administration of T4 (0.1 mg/kg, s.c.) for 4weeks by augmenting all the above parameters. Conclusions: T4 exhibited neuroprotective activity, which would be attributed to its activity as neurotrophic effect.

62-69

Authors: Baweja Himanshu, Mishra Shyam, Mehta Yatin.

Indian Journal of Pharmacy and Pharmacology is a International, scholarly Peer-reviewed Journal which Published Four times per year by Innovative Publication. The journal publishes original and high-quality research papers in all areas of pharmacology and pharmacy. As an important academic exchange platform, scientists and researchers can know the most up-to-date academic trends and seek valuable primary sources for reference. The journal also publishes articles, reviews, etc., on any issues from the broadest range of Pharmacy and Pharmacology traditions and that cross disciplinary boundaries, through which it tries to provide the latest information on developments in Pharmacy and Pharmacology, and each issue is striving to bring you critical perspectives and cogent analyses.

74-82

Authors: Syed Ehtaishamul Haque, Ravindra Kumar Verma, Vasim Khan, Sumit Sharma

This review deals with homeopathic approach of treatment where focus is given to its principle, potency concept dosing pattern and symptomatic treatment. Special attention is given to a homeopathic drug Cactus grandiflorus. This review is a compilation of all therapeutic benefits of Cactus grandiflorus, giving more stress on cardioprotection.