ANTIMICROBIAL ACTIVITY EVALUATION OF SOME (Z)-2-(2-OXO-1-((ARYLAMINO)METHYL)INDOLIN-3-YLIDENE)-N-(4-(2-OXO-2H-CHROMEN-3-YL)THIAZOL-2-YL)HYDRAZINE-1-CARBOXAMIDES
Authors: Mohd. Imran*
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yl)hydrazine-1-carboxamides 4a-4n were prepared by treating (Z)-N-(4-(2-oxo-2H-chromen-3-yl)thiazol-2-yl)-2-(2-
oxoindolin-3-ylidene)hydrazine-1-carboxamide 3 with the aryl amines and formaldehyde. The chemical structures of
these compounds were elucidated by their physical constants, spectral data and elemental analysis. These
compounds were investigated for their antimicrobial activity against five Gram-positive bacteria, namely, S. aureus,
E. faecalis, S. epidermidis, B. subtilis and B. cereus; five Gram-negative bacteria, namely, E. coli, P. aeruginosa, K.
pneumoniae, B. bronchiseptica and P. vulgaris; and five fungi, namely, C. albicans, A. niger, A. flavus, M.
purpureous and P. citrinum by serial plate dilution method using standard drugs, ofloxacin and ketoconazole,
respectively, and their minimum inhibitory concentrations (MICs) were also determined. These compounds showed
mild to moderate antibacterial activity against Gram positive as well as Gram negative bacteria. However, they
exhibited better antifungal activity. The compound 4j (Ar = 1,2,4-Triazol-4-yl) has been identified as the most
promising antifungal agent of this series. There is a possibility that the replacement of triazole ring by other azole
ring .e.g. imidazole and 1,2,3-triazole; and / or the presence of halogen substituted coumarin ring may produce
promising potent antimicrobial agents that are effective against Gram positive bacteria, Gram negative bacteria
Keywords: Antibacterial activity, antifungal activity, coumarin, isatin, thiazole.