Serum Adiponectin Level and Clinical, Metabolic, and Hormonal Markers in Patients with Polycystic Ovary Syndrome
Authors: Yunus Yildiz , Gülnur Ozaksit , Bekir Serdar Unlu , Emre Ozgu , Hasan Energin , Metin Kaba , Mustafa Ugur
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Background: To investigate the relationship between adiponectin, metabolic and hormonal
parameters, and insulin resistance in patients with non-treated polycystic ovary
Materials and Methods: In this cross-sectional observational study, 81 patients admitted
to out-patient clinic with complaints of menstrual irregularity, hirsutism and obesity were
enrolled. Serum adiponectin, biochemical and hormonal parameters, and 75 gram oral glucose
tolerance test (OGTT) were measured. Spearman’s correlation coefficient was used
for statistical analysis.
Results: We observed inverse correlations between serum adiponectin level and body
mass index, homeostasis model assessment insulin-resistance score, insulin level, fasting
glucose level, and prolactin level (p=0.001, p=0.02, p=0.04, p=0.02, and p=0.005,
respectively). No significant correlations were found between serum adiponectin level
and age, height, weight, Ferriman-Gallwey score, 2 hours OGTT test value and free testosterone
level (p=0.3, p=0.6, p=0.2, p=0.8, p=0.9, and p=0.01, respectively).
Conclusion: The present study demonstrated that in polycystic ovary syndrome patients,
when serum adiponectin level decreased, degree of insulin resistance increased. Our findings
indicate that serum adiponectin level is likely to be an adequate marker for determination
of the degree of insulin resistance, and may be a predictor of diseases, such as
type 2 diabetes mellitus (T2DM) and metabolic syndrome, which develop on the basis
of insulin resistance.