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Prevalence and clinical significance of interactions drug-enteral nutrition in Intensive Care Units
Authors: Adriano Max Moreira Reis, Rhanna Emanuela Fontenele Lima de Carvalho, Leila Marcia Pereira de Faria, Regina Célia de Oliveira, Karine Santana de Azevedo Zago, Milena Ferreira Cavelagna, Adriano Gomes Silva, Manoel Luis Neto, Silvia Helena de Bortoli Cassiani
Number of views: 375
This is a multicenter, cross-sectional retrospective study, which aimed to determine the prevalence of interactions drug-enteral nutrition (EN) in Intensive Care Units (ICU) of seven teaching hospitals in Brazil, and to analyze the clinical signifi cance of them. Information on medications and EN administered with 24 hours and 120 hours of hospitalization were collected. For identification of drug-EN interaction was employed software Drug Reax®. It was investigated 1.124 records. Of these, 320 patients, with 24 hours of hospitalization, were on EN, and 20 (6.3%) had drug-EN interaction. Of the 504 patients with 120 hours of hospitalization, 39 (7.7%) had drug-EN interaction. The most frequent drug-EN interactions of clinical significance were phenytoin-EN, warfarin-EN and levothyroxine-EN. Drug-EN interactions may interfere with the quality and cost effectiveness of care in ICU, so it is essential that the health team has knowledge about them.
Key words: Drug Interactions; Food-Drug Interactions; Enteral Nutrition.