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Frequency of Thyroid Dysfunction Among Diabetes in Punjabi Population
Authors: Gurjeet Singh*, Vikas Gupta**, Anu Kumar Sharma*** and Neeraj Gupta****
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ABSTRACT : The aim of the present study was to examine the frequency of thyroid disease among diabetes in
Punjabi population and to investigate the effect of Diabetes mellitus on thyroid hormone levels and other biochemical
variables. The totals of 200 subjects including 100 diabetic (20 type 1 and 80 type 2) and 100 non
diabetic controls subjects were included in the present study. Each patient was investigated for plasma glucose
fasting (FPG), glycosylated hemoglobin (HbA1c), serum cholesterol, serum triglyceride, high density lipoproteins
(HDL) low density lipoproteins (LDL), very low density lipoproteins (VLDL), blood urea, serum creatinine,
SGOT, SGPT, total triiodthyronine (T3), total thyroxine (T4), free triidothyronine (FT3) free thyroxine (FT4)
and thyroid stimulating hormone (TSH).Patients with diabetes showed significantly higher levels of TSH, FPG
, HbA1c, serum cholesterol, serum triglyceride, LDL, VLDL, blood urea, creatinine, SGOT, SGPT and significantly
lower levels of T3, T4, FT3, FT4 and HDL as compared to non-diabetics. Among the 100 diabetics patients
studied 29% shows abnormal thyroid hormone levels (24% had hypothyroidism and 5% had hyperthyroidism)
whereas in 100 non diabetics subjects only 4 % of the subjects were having abnormal thyroid dysfunction.