Journal of Natural Remedis

131-143

Authors: Azizah Hikma Safitri, Nurina Tyagita and Taufiqurrachman Nasihun

Background: Porang glucomanan has been shown to have a potential properties for the prevention of Metabolic Syndrome (MetS). This study aimed to confirm that porang glucomannan supplementation can improve lipid profile in metabolic syndrome induced rats. Methods: Thirty male Sprague-Dawley rats were randomly divided into 5 groups consisting a contol group standard diet (Normal); Metabolic Syndrome group (SM), metabolic syndrome group + 25mg/200gBW Porang Glucomannan (GMP25), metabolic syndrome group + 50mg/200gBW Porang Glucomannan (GMP50), and metabolic syndrome group + 100mg/200gBW Porang Glucomannan (GMP100). The lipid profile before and after induction with high-fat and high-carbohydrate diet, and after 28 days of porang treatment were evaluated. Data were analyzed using One Way Anova followed by LSD post hoc test. Results: GMP100 rats showed the highest reversal of diet-induced changes, with decreased total cholesterol (TC), triglycerides (TG), and LDL, and also increased HDL level. The mean levels of TC, TG, and LDL in GMP100, GMP50 and GMP25 was significantly lower than those of in MS (p = 0.000), and was significantly higher than those of normal (p = 0.000). While the levels of HDL in GMP 100, GMP50, and GMP25 was significantly higher than those of MS (p = 0.000), but significantly lower than those of normal (p = 0.000). Conclusion: Porang glucomannan supplementation improve lipid profile in metabolic syndrome diet rats, with best dose at 100 mg/200 gBW.

154-164

Authors: Eman Ramadan Elsharkawy and Mohamed H. Shiboob

Genus Artemisia are desert plants spread in the Egypt and Saudi Arabia. The methanol extract of the aerial parts of Artemisia herba alba and Artemisia judaica grown in the arid zones in the Northern regions of Saudi Arabia and North Sinai, in Egypt were subjected to the primary phytochemical analysis which, showed the presence of phenolic compounds, flavonoids, tannins and sterols. The GC-MS analysis of the methanolic extract exhibited numerous compounds, 11 compounds were identified as phenolic compounds, ferulic acid, ursodeoxycholic acid and derivatives of cinnamic acid (ethyl cinnamate). The highest phenolics content in A.herba alba grown in Saudi Arabia was observed for methyl cinnamate, (8.2 %) and the lowest methyl ferulate (0.02 %) for A. judica grown in Egypt. The quantization analysis of GC-MS revealed high amount of phenolic acid in the plant grow in Saudi Arabia than the plant collected from Egypt. The radical scavenging activities of two plant were studied by 1,1-diphenyl -2-pycrylhydrazyl (DPPH), EC (50) values were determined for A. herba alba and A. judaica (0.122, and 0.56 mg/ml) growing in Saudi Arabia and A. herba alba and A. judaica (1.7 and 0. 67 mg/ml ) growing in Egypt. Total alkaloid content was analysed and some alkaloid compounds was identified by GC-MS, viz. dasycarpidan-1-methanol, acetate, pseudosolasodine diacetate and morphinan4,5epoxy3,6-diol. Certain compounds were rich in Saudi plant but not detected in plants grown in Egypt, which reflect the role of environment adaptation of plant by accumulation of only certain compounds.