Current Research in Pharmaceutical Sciences

01-10

Authors: Ashwani Mishra, A K Pathak

Plasticizers have got significant role in pharmaceutical formulations because of their vital importance in the formulations like gastro-retentive films, ocular films, transdermal films, buccal films, oro-dispersible films. Flexibility, Endurance, Resistibility and Stability which are suitable properties of formulation could be easily achieved by using plasticizers which ultimately imparted desired characteristic in the formulation by the radical use of this excipient. In this review an effort was made to disclose importance, theories and plasticizers mechanism in different novel pharmaceutical formulations to understand its versatility efficiency, utility and tendency to modified different novel pharmaceutical formulations.

16-24

Authors: Amit Kumar Tiwari, Preveena Narasimhamurthy, Gopalpur Nagendrappa, Abhilash Thakur

2-Chloroquinoline-3-carbaldehyde and its substituted products are extremely versatile intermediates for synthesizing a variety of compounds containing quinoline moiety, which find many pharmaceutical and other applications. Quantitative structure-activity relationship (QSAR) plays an important role in toxicity prediction. The present study deals with acute toxicity predictions LD50 (medianlethal dose) values of (3-(2-chloroquinolin-3-yl)oxiran-2-yl)(phenyl) methanone and its derivatives in rat by oral exposure through QSAR modelling software package T.E.S.T. In the present study the toxicity (LD50) is evaluated using a variety of QSAR methodologies, such as hierarchical clustering, the Food and Drug Administration (FDA) MDL, nearest neighbor and a consensus model. For compounds No. 1 to 4, 7, 10 and 11 hierarchical clustering method does not provide the LD50 values; however, other methods have successfully provided the toxicity estimation for the same. The said software helps to predict the exact LD50 values when compared to experimental data reported in the range (>2000 to >5000 mg/kg). This is a preliminary observation from screening of LD50 values using the said software package. Further study may be relevant using other software to compare the predicted data.

30-32

Authors: Samreen Jahan, Jagdish K Sahu

A market survey of Amlodipine (Antihypertensive drug) was conducted at several medical shops in Moradabad City. The various brands of Amlodipine are Citanil-T, Amlokind, Omletime, Amodep, Angicam, Lupidip, Amlogen,Amlip etc. are available in selected areas. The Amlokind is more prescribed by doctors. The highest selling brand of Amlodipine is Amlokind. According to medical survey it has been shown that Amlokind (Mankind Pharmaceuticals Pvt Ltd.) is highest selling brand in Moradabad city. Amlodipine is good Antihypertensive drug.