Current Research in Pharmaceutical Sciences

1-4

Authors: Shivam Tayal

Non-steroidal anti-inflammatory drugs usually abbreviated as NSAIDs, are the drugs withanalgesic, antipyretic and, in higher doses, with anti-inflammatory effects. NSAIDs inhibitcyclooxygenase (COX) 1 and 2. So, most of the side effects develop as a result of cyclooxygenaseinhibitory activity.Lornoxicam is a strong analgesic and anti-inflammatory NSAID of the oxicamclass with better tolerability profile when compared to other NSAIDs.Its analgesic activity iscomparable to that of opioids.It has been shown to be effective in the treatment of postoperativepain and rheumatoid arthritis(RA).The present review provides an overview of lornoxicam.

11-13

Authors: Shyam Gupta, Piyush Gupta, Surendra Patsariya

Fenugreek (Trigonella foenum-graecum) known as Methi is being used in traditional medicine. It has been found to have antimicrobial, wound healing, antifungal, anti-diarrheal, hypoglycemic, hepatoprotective, antioxidant, antihelmintic, anti-diabetic, anti-inflammatory activity. It also used in treatment of small pox and hair loss. The seed contains two alkaloid namely choline, and trigonelline. It also contain four flavanoid (two glycosides and two aglycones) and two steroidal saponins.

16-21

Authors: Sanjay Sharma, Anshita Gupta, Harish Niranjan, Manoj Goyal

Aquasomes are nanoparticulate carrier system but instead of being simple nanoparticles these arethree layered self assembled structures, comprised of a solid phase nanocrystalline core coated witholigomeric film to which biochemically active molecules are adsorbed with or withoutmodification.The drug delivery vehicle aquasome is colloidal range biodegradable nanoparticles, sothat they will be more concentrated in liver and muscles. Since the drug is adsorbed on to the surface of the system without further surface modification they may not find any difficulty inreceptor recognition on the active site so that the pharmacological or biological activity can beachieved immediately.

26-30

Authors: Satish A Patel , Pramel K Parikh

Three simple and sensitive spectrophotometric methods have been developed for determinationof phytomenadione in injection. Method A is simple UV spectrophotometric method based ondetermination of phytomenadione in methanol at 249 nm. Linearity was obtained in theconcentration range of 2 – 14 ug/ml. Method B is first order derivative spectrophotometric method and involves estimation of phytomenadione in methanol using the first - order derivativetechnique at 259 nm as maxima and 276 nm as minima. Calibration curve was prepared byplotting the absorbance difference between maxima and minima versus concentration. Linearitywas obtained in the concentration range of 2-14 μg/ml. Method C is area under curve (AUC)method. The method involved calculation of integrated value of absorbance with respect to thewavelength between two selected wavelength 241 nm and 280 nm, respectively. Linearity wasobtained in concentration range of 2- 14 μg/ml. These methods were successfully applied topharmaceutical formulations because no interferences from injection excipients were found. Thesuitability of these methods for the quantitative determination of phytomenadione was proved byvalidation. The proposed methods were found to be simple and cost effective and can beemployed for the routine quality control application of phytomenadione in pharmaceuticalformulations.

34-41

Authors: D.K. Agrawal, O.P. Agrawal and Sita Agrawal

Due to their importance in processing the organic materials, enhancing the fertility of soil and their supportive role to the agriculture and due to interest of biologists in the study of animals and plants, earthworms had been subject of attention of several workers. Earthworms constitute a large part of biomass in the soil. They have been recognized as soil movers and conditioners. In this study, efforts have been made to compare the growth and reproductive potential of Perionyxexcavatusand Perionyxcressiseptatusby using a common substrate or culture material such as cattle dung waste that had not been explored extensively in previous studies. The effect of different months on growth and reproduction of Perionyx excavates and Perionyxcressiseptatuswas studied at vermicomposting center. For each month, viz., 50 gm adult earthworms per 5 kg of cattle dung were inoculated and monitored for total biomass gain, cocoons production, sexual maturity. Mortality was not observed in any month. The better performance (% change) with reference to biomass and bio number was agreed by Perionyxexcavatusin the month of July while Perionyxcressiseptatuswas generated in the month of August.