European Journal of Medicine. Series B

Number 1 (5), 2016

4-11
Immunological Reactivity and Nonspecific Resistance in Children with Hearing Loss Depending on Genes' Polymorphic Variants CJB2 (C.35DELG) and IL-4 (C-590T)

Authors: Oksana M. Iftoda, Larysa P. Sydorchuk, Oksana V. Kushnir, Yulia V. Repchuk

Abstract

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The general and cellular immunological reactivity and nonspecific resistance in 102 children of Bukovina region (Western Ukraine) with conductive or sensorineural deafness / hearing loss (CHL, SNHL), aged from 8 to 18 years, depending on the polymorphic variants of genes CJB2 (c.35delG) and IL-4 (C- 590T) were analyzed. General immunological reactivity in children with CHL 35delG-genotype carriers of CJB2 gene is characterized by higher humoral activity; cell immunological reactivity in CHL persons didn't depend on the CJB2 and IL-4 genes' genotypes. Endogenous intoxication prevails in 35delG-genotype carriers of CJB2 gene vs Non-del carriers, more in CHL than SNHL children - by 9.72 %; exogenous intoxication of infectious origin is present and higher significantly in CHL children with 35delG genotype of GJβ2 gene and TT genotype of the IL-4 gene. The manifestations of infectious inflammation in CHL persons with TT genotype of the gene IL-4 associated with lower humoral immunity activity 2,01-3,46 times, and testified the predominance of macrophage defense mechanisms over microphage, lower general reactivity, propensity for primary chronic course of disease. The general immunological reactivity changes in SNHL children depending on the gene IL-4 genotypes were not established.

12-17
The Causes of Borderline States from the Standpoint of Reliability Theory

Authors: Leonid S. Khodasevich

Abstract

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The article examines the opportunity of formalizing the ideas about the causes of borderline states, due to the functional overload of various etiologies, theoretical concepts in terms of reliability theory of redundancy, redundancy and failure. The borderline states depending on the state of regulatory systems and adaptation mechanisms are characterized by: prenosological state – tension of regulatory systems and adaptation mechanisms while preserving them alone, but with a decrease in the load; premorbid – poor adaptation to the environment, while maintaining homeostasis due to a significant tension of regulatory systems or the inclusion of additional reserve capacity.

18-25
The Cardiotonic Effects of Cycloartane Glycoside – Astragaloside VII

Authors: Shunkor Khushmatov, Manzura Agzamova, Kuzidjan Baratov, Utkir Inagamov, I.M. Isaev

Abstract

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Number of views: 584

The aim of the present study is to determine the inotropic effect of astragaloside VII on rat papillary muscle. Mechanical activity of muscles was recorded with isometric force transducer (Type SI–KG20; World Precision Instruments Inc.; USA). It is established, that astragaloside VII demonstrated biphasic positive inotropic action, this effect can be caused by its modulation of β–adrenoreceptors and Са2+–transporting systems cardiomyocites.

26-33
The Impact of Targeted Adjustment of Motor Dynamic Stereotype on Psychological and Vegetative Profile of Patients with Cervical Myofascial Pain Syndrome

Authors: Egor Yu. Melnikov, Aram F. Khechumyan, Antonina V. Polyakova

Abstract

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Number of views: 467

The study involved 237 patients with cervical myofascial pain syndrome (MPS) of stage II (121 women and 116 men) in the age of 36.5±12.7 years. At the time of examination and treatment of patients there was no organic pathology of the spine and extremities. All patients received a course of physiotherapy (LH), which consisted of 10 sessions over 14 days. The article studies the impellent stereotype in patients with cervical myofascial pain syndrome means of medical physical culture. It is found that the change occurs in patients in the psychological and vegetative profile in a positive way, as when using the traditional methods as well as the author's, and at last the results are significantly better.

34-37
The Dynamics of Cytokine Concentrations in the Blood Serum during Treatment with Catarrhal Gingivitis by Unimag

Authors: Nana K. Natsvlishvili, Lela Kiparoidze, Magda D. Davitashvili

Abstract

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The results of study of Concentration Dynamics of cytokines TNFa, IL 1 and IL 8 in blood senum and percentage quantity of gram positive microbes in mouth cavity on the background of treatment with Unimag while catarrhal gingivitis are presented. Preparation Unimag is stable suspension of highly-sispersed particles of magnetitis, magnetic fluid. Unimag is magnetis-sensitive, radiopaque, bactericidal, characterized by varions bio-macromolecules absorption, increase of functional activity of phagocytes and high penetration ability in tissues. The studies revealed that on the background of treatment with unimag of patients with catarrhal gingivitis Speedy SubstitutIon of gram-negative microbes by gram-positive microorganisms peculiar to mouth cavity took place. Efficient bactericidal and bacteriostatic action on microorganisms, reduction of cytokines TNFa, IL 1 and IL 8 that has essential importance for efficient treatment activities while initial forms of parodontitis and considerable improvement of trerapetic effect.