INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES

763-770

Authors: Shravan Kumar Dholi 1 , Ruqsar Khanam 2 , S. Malathi 2 , P. Akhila 2 , P. Abhilash 2 .

Skeletal muscle activity of Fenugreek seeds extract and Fenugreek leaves extract were studied in the green frog (Rana hexadactyla) by the rectus abdominis muscle preparation. Fenugreek seeds extract and Fenugreek leaves extract with distilled water 1μg/ml, 10μg/ml and 100μg/ml concentrations. The result indicated that the treatment of Fenugreek seeds extract and Fenugreek leaves extract alone and combination with acetylcholine produce skeletal muscle activity. Thus from the present study it was concluded that Fenugreek seeds extract and Fenugreek leaves extract were have good skeletal muscle activity alone and combination with Acetylcholine. Fenugreek leaves extract have more potent skeletal muscle activity than Fenugreek seeds extract. Keywords: Skeletal muscle activity, Fenugreek seeds extract and Fenugreek leaves extract Rana hexadactyla, Acetylcholine.

780-789

Authors: Remedan Anuwer1*, Muluneh Fromsa Seifu1 , Belayneh Kefale Gelaw1 , Thirumurgan Gunasekaran1 , Esayas Tadesse Gebremariam1 , Mustefa Ahmed Mohammed1

Background: Hypertension (HTN), or high blood pressure (systolic blood pressure >140 mmHg and diastolic blood pressure >90 mmHg) is an overwhelming global challenge which ranks third as a cause of disability-adjusted life-year. Hypertension causes 7.1 million premature deaths each year worldwide and accounts for 13% of all deaths globally. There are effective medical therapies for hypertension management; but the problem of non-adherence to medical treatment remains a challenge for the medical professionals and social scientists. The objective of this study is to assess the magnitude of adherence and factors for non adherence related to anti-hypertensive treatments in hypertensive patients visiting Adama Referral Hospital. Methodology: An institution based cross-sectional study was conducted at Adama Referral Hospital to assess patient adherence towards antihypertensive therapy. The data was collected by using a pre-tested structured questionnaire after translated to local language, in exit interview method immediately after the patients have got the service, and the collected data was processed and analyzed by using SPSS version 20 computer software. Result: There were 96 respondents during the study period, from 96 respondents 42(43.75%) were males and the rest were females. Among the respondents 33.34% were > 64 years old and 20.83%% were employed. Regarding the educational level larger proportions of respondents can read and write. Among the study population 45.83% of the respondents were orthodox and only 3.12% were others. 29.16% of the respondents had an income of 100-800 Ethiopian birr per month. Majority of respondents were non adherent due to lack of money. It was found that the level of education does not significantly affect knowledge towards adherence. Also majority of patients >64 ages were non adherents to their medication. Conclusion: The overall research finding shows that among 96 respondents of hypertensive patients in Adama Referral Hospital 44(45.8%) were non adherent to the prescribed medication. It was recommended that health professionals must educate hypertensive patients about their disease with specific emphasis on its causes, the severity of the disease, their medications and the consequences of non-adherence with treatment. Keywords: Hypertensive Patients, Adherence, Adama, Prescribed Medicatio

796-800

Authors: Gurfateh Singh, Deepika Bhatia, S.L. Hari kumar

Camellia sinensis is commonly known as Green Tea which is most consummated beverage in the world. The diversify properties of the C. sinensis encourage us to new research in few recent years. There are lots of finding in the process of the tea and there are so many positive aspects also found in it. Present review is an attempt to summarize the various pharmacological effects like anti hepatoprotective and antioxidant activity, a powerful protective tool for future era. This article is enlighting the possible beneficial effects of green tea on the drug/chemicals induced hepatotoxicity. Keywords: Green tea, Hepatoprotection, EGCG

815-826

Authors: Sudarshan B. Aher* , Kajal S. Gahide

Fast Dissolving Tablet accommodation the organization and enhanced patient consistence are vital in the outline of oral drug delivery framework. which remains the perfect course of drug delivery inspite of different burden of Oral course having the most noteworthy patient consistence is viewed as the most suitable, most secure furthermore the most efficient system for drug delivery. Quick dissolving tablets is one such most beneficial sample of the oral drug delivery. These tablets promptly break up or crumble in the salivation i.e.within 60 sec without the requirement for water. They have been defined for pediatric, geriatric and out of commission patients. These kind of dose structures are likewise perfect for dynamic patients who are occupied and voyaging and might not have entry to water. FDTs have increased generous consideration for those patients who experience issues in gulping on account of dysphagia, hand tremors issues have supplementary playing point for oblivious, youthful patients with immature solid and sensory system. This article endeavors to present a complete survey with respect to innovative advances made so far in the zone of assessment of quick dissolving tablets as for unique qualities of these special measurements structures. Keywords: Fast Dissolving Tablet, Dysphagia, Superdisintegrants, Patented Technology.

833-836

Authors: Shakeel Ahmed*1 , Mohammad Idris2 , Mohd. Adnan3

Unani medicine is a component of Ayurveda, Yoga & Naturopathy, Unani, Homoeopathy (AYUSH) stream of nonconventional medical systems in India. Since centuries, these systems have been flourishing with the social and cultural acceptance of the general masses. However, standardization/quality control of herbal formulations belonging to these system have become the Achilles’ heel. The national and international regulatory agencies have given guidelines for standardization/quality control of herbal formulations in terms of batch to batch quality control and quality assurance. The present study was an effort to prepare and standardize Habb-e-Asgand, a Unani polyherbal pharmacopoeial formulation, used as an anti-inflammatory drug, especially for arthritis/joint diseases. The various parameters performed for the finished products including organoleptic characteristics, physicochemical analysis in order to establish its standardization. Keywords: Standardization, AYUSH, Habb-e-Asgand, anti inflammatory drug, arthritis.

843-850

Authors: Syed Umar Farooq*, V. Kranthi Kumar, M. Vamshi Krishna, R. Srividya, Dr. D. Sudheer Kumar

Portulaca quadrifida is widely distributed in Africa and tropical Asia in India they are consumed as a cooked vegetable. review of records and scientific literature indicates that portulaca has many medicinal uses like in treatment of ulcers, eczema and dermatitis1 .The 10%ethanolic extract of the aerial parts (dried leaves and stems) showed significant anti bacterial anti acne and anti inflammatory activity Commonly used benzoyl peroxide and clindamycin show many side effects herbal gel was formulated using extract of Portulaca Quadrifida for the treatment of acne . keywords: portulaca qadrifida ,Anti acne, Anti inflammatory

857-862

Authors: Pramod K. S , Neha. P , Sameer. S. B.

Food crops exhibited different traits of agronomic importance. Chickpea is one such food crops which preferred in Asia; being major source of protein after milk. Chickpea being self-pollinated crop hence is supposed to display little genetic variation. A number of both protein and DNA based markers are available for the effective quantification of genetic variations in plant genomes. The protein based markers having sizable limitations hence, DNA based markers are more suitable as a choice. Thus genetic marker assisted selection is becoming a more reliable current trend in the modern day agriculture. Such DNA markers are fingerprints of a species in revealing polymorphism at molecular level. Molecular techniques using DNA polymorphism has increasingly been used to characterize and identify a novel germplasm for use in the crop enhancement programs. Key Words: RAPD, ISSR, DNA polymorphism, Chickpea.

870-877

Authors: G. Sai Sri Harsha*1 , A.Kavitha1 , V. Jayasankar Reddy1 , K. Ramesh Reddy 1 , K. Anil 2

Diabetes Mellitus is a health problem worldwide. The most effective anti-diabetic drugs currently available include insulin and newer insulin preparations, sulphonylureas, biguanides, meglitinides, thiazolidinedione, alpha-glycosidase inhibitors, incretins, glucomannan. However, he future therapies will need to focus on those patients who do not respond well to these treatments and who account for 50% of the health care costs of Diabetes Mellitus. Drug development for diabetes mellitus has been directed at improving currently available drugs and findings new compounds. The chemical entities able to target the metabolic disorder. The main aim of article is This was a prospective observational study, conducted over 6 months period from April 2011 to September 2011, for assessing the impact of patient counseling on quality of life in type 2 diabetes mellitus in a tertiary care teaching hospital. Key words: Diabetes Mellitus,Insulin,sulphonylureas,alpha-glycosidase inhibitors