INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES

510-513

Authors: Virani Paras1, 2*Rajanit Sojitra2, Hasumati Raj2, VineetJain2

Abstract Hypertension is currently measure disorder obtain in the world population. Irbesartan is classified as an angiotensin II receptor type 1 antagonist. Angiotensin II receptor type 1 antagonists are widely used in treatment of diseases like hypertension, heart failure, myocardial infarction and diabetic nephropathy.The clinical and pharmacological analysis of this drug givesidea about effectivity of this drug in hypertension condition.Irbesartan act on renin angiotensin system and decreases biding of angiotensin to the receptor so decreases the blood pressure and act as an antihypertensive agent. Irbesartan is tetrazole derivative which selectively inhibit or antagonise the angiotensin type II receptor. In this review gives detail about mechanism of action of irbesartan in hypertension. Keywords: Irbesartan, Hypertension, Anti hypertensive drug, Angiotensin ii receptor antagonist.

523-528

Authors: Mahendran Sekar*, Tuan Aimi Nabihah, Siti Nur Zalira, Nurul Syifa’a, Meru Pratistha Subramaniam, Wan Putri Imana, Mohd Syafiq Abdullah

ABSTRACT Plant mucilages are found as common ingredients in cosmetic, pharmaceutical, food and non-food industries due to their low cost compared to the synthetic polymers. The synthetic polymer such as excipients suffer from many disadvantages such as high cost, toxicity, non-biodegradability and environmental pollution caused during their synthesis. In the present study mucilage was isolated from the seeds of Durian and Rambutan fruits and characterized by physicochemical properties. This includes organoleptic evaluation, solubility, pH, angle of repose, bulk density and tapped density. Taking all the above parameters into consideration, the study has revealed that the mucilage obtained from Durian and Rambutan seeds were good candidates to use as a tablet binder and also for further studies. KEYWORDS: Durian, Rambutan, Mucilage, Physicochemical properties

539-542

Authors: Shabir Ahmad Bhat1, Aysha Raza2, ParasWani3, Shahbuddin4

Abstract: Dysmenorrhea is the most common of gynecologic complaints. It affects half of all female adolescents today and represents the leading cause of periodic college/school absenteeism among that population. To evaluate the menstrual problem specially dysmenorrhea and its severity in female medical students and its effect on their regular activities. They affect 80% of women at some time in their lives; usually they are not assigning of a serious underlying problems. It is a condition where there will be painful menstruation associated with abdominal cramps, backache, nausea and vomiting, stiffness in thighs, cramps in calf muscles. Pain usually last for 2 or 3 days and tends to happen in the first few days of the period. Up to 15% of women have period pains, severe enough to interfere with their daily activities. This can lead to missing days at work or diseased participation in social or sporting activities. Dysmenorrhea is of two type namely primary and secondary dysmenorrhoea. Primary dysmenorrhoea is used to describe normal period pain experienced by many women during the time of their period and there is no underlying medical problem. Secondary dysmenorrhoea is used to describe pain results of an underlying gynecological problem. There are number of measures like sitz bath, simple morning walk and dietotherapy. There are number of herbal drugs mentioned in Unani literature which are useful in tackling this problem. The review highlights about dysmenorrhoea and some of those herbal drugs which are used in Unani System of medicine. Keywords: Dysmenorrhoea, herbal drugs, Unani system of medicine, Back ache, Usre tams

548-551

Authors: Bilal Aslam*, Ahmad Raza, Ijaz Javed, Tanweer Khaliq, Faqir Muhammad, Junaid Ali Khan, Asghar Ali, Shamshad-Ul-Hassan

Abstract Cancer is a Persistent, Purposeless and Proliferative growth which is a leading cause of death worldwide. Amongst all cancers lung cancer is most important world widely which is divided into small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). Pancoast tumors (PTs) are primary lung carcinomas arising from the apex of the lung and are generally located in the superior pulmonary sulcus. In most cases, PTs are NSCLCs, most commonly squamous cell with prevalence of 52%, followed by adenocarcinomas and large cell carcinomas as 23% and 20% respectively; only about 5% of PTs are of small cell origin. PT cause characteristic symptoms, such as arm, shoulder, radicular pain and muscle weakness in the distributions of C8, T1, and T2 nerve roots. PTs are very difficult to diagnosis early on stage. Different diagnostic tools like radio graphs (X-rays), Computed Tomography (CT) scans, bronchoscopy, Magnetic Resonance Imaging (MRI) and biopsy. Traditional treatment of PTs includes localized approaches like chemotherapy, radiotherapy, surgery (anterior or posterior approach) or combination of these. Keywords: Cancer, Lungs, Pancoast Tumors, SCLC, NSCLC, CT Scan, MRI