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Synthesis and in-vitro Anti-platelet aggregation activity of some New substituted Thiophenes
Authors: Jagadish ER1, Mohan S1, Saravanan J, Satyendra D*, Swetha Sree P, Apurba T, Manoj K, Rama Kanta S
Number of views: 416
Plan: To synthesize some novel 2-amino thiophenes with various substitutions at 2-amino position for anti-platelet aggregation activity.
Preface: Various substituted and condensed thiophenes are reported to possess a wide variety of biological and pharmacological activities such as antibacterial, antifungal, anti-inflammatory, anti-platelet aggregation activity, antipyretic, antitumor and so on. Thus a series of new thiophenes have synthesized with various substituents at 2-amino position and screened for anti-platelet aggregation activity.
Methodology: The starting material (JMS-2) was prepared by the application of versatile Gewald reaction. It was then derivatized to various Schiff bases JMS-2(a-m) by reacting with various substituted aromatic aldehydes. The synthesized new compounds were characterized by MP, TLC, IR, NMR and Mass spectra and were screened for their In-vitro anti-platelet aggregation activity by GVR Born method using Heparin as the standard.
Outcome: Compound JMS-2a, JMS-2b, JMS-2d and JMS-2i showed good % inhibition and were found to be more significant.