The Journal of V. N. Karazin Kharkiv National University. Series «Medicine»

5-9

Authors: V.P. Tretyak, P.P. Ryzhko

The necessity of improving the Law of Ukraine regarding HealthCare, in correspondence with the modern socio-economic circumstances Ukrainian population vital functions for providing effective and high-quality medicare, principal reorganization and modernization of medical network, staff, new schemes of financing, economic management, technological communications and methods of the Health Care system.

14-18

Authors: E.S. Protsenko, N.A. Remnyova, A.O Ponomaryov

For the first time, the structure of thymus disease incidence in Kharkiv region within the period of 1990-2005 was investigated and analyzed. Two hundred and forty four cases of thymus diseases (173 women and 71 men) were registered during this period. The most frequent disease of the thymus in women is hyperplasia, in men – lymphoepithelial thymoma.

23-29

Authors: I.V. Griga, V.I. Griga

The removing of the kidneys under the skin of white rats results in the development of hypertension and the increase of oxygen absorption by the tissues of the body. These processes are stimulated in case of additional physical exertion by swimming in the water-pool. Giving the extracts of Astragalus glycyphyllus, Astragalus cicer, Veronica officinalis, and as well as Melittis melissophylum and Eleagnus angustifolia to the experimental animals with kidney hypertension and physical exertion contributes to the decrease of arterial pressure, cholesterine and beta-lipoproteids, to the normalization of tissue breathing and peroxidation of lipids.

35-40

Authors: E.M. Krivonosova

It was performed the investigation of gastric and duodenal mucous layer functional condition in patients with insulindependent diabetes mellitus. It was characterized pH-metric, endoscopic and pathomorphologic percularities of gastroduodenal system on a background of diabetic gastropathy, chronic gastritis and duodenal ulcer. The conclusion about expediency of H. pylori eradication therapy, metabolic, prokinetic and immunotrophic medications assignment for the treatment of diabetic patients with gastrodudenal disorders.

43-46

Authors: G.A. Oleinik

There were detected a lot of morphological changes of internal organs in patients after the general and local cold injuries.

49-52

Authors: E.A. Romanova, A.V. Martyno, N.I. Igumnova, T.A. Sidorenko, V.I. Chernyavsky, M.V. Smelyanskaya, S.D. Peremot

In the article were presented results about studied of immunopotential activity of new IL-2 – acylated derivatives. It was show, that preparation much increased spontaneous blasttransformation of lymphocytes in mice as in vitro and in vivo. Added of acIL-2 to lymphhocete’s cells culture resulted to more increasing of mitotic activity of lymphocytes than in control with native Roncoleukin.

55-60

Authors: V.O. Fedoryshcheva, М.І. Yabluchansky, W. Arnold, E.O. Naumova

It was the aim of this study to compare two different methods of linear and angular craniometric measurements of the neuro - and viscerocranium. Of 38 normal skulls of adult individuals from Verhnij Saltovskij moglinik lateral x-rays were taken with a PYM-20 x-ray machine at 40-45 kV electron beam and an exposure time between 0.1 to0.2 sec. As base points for the measurements served either the center of the sella turcica (point S), or the back edge of the tuberculum sellae (point S’). Linear and angular marks were measured between the following points: Ba, B, L, N, O, Or, Pr, S, S', Fca. The mean value (M, cm), standard quadratic deviation (sd) were determined. Statistical analysis between groups was carried out using the Mann-Whitney test. The results showed distinct differences between linear and angular measurements using the different base points. It is concluded that in anthropological research for craniometric measurements the internationally recommended S point as standard base point should be used.

67-71

Authors: А.I. Thsivenko

The results of the intraoperative diathermy knife and ultrasonic scalpel use are presented in the paper. The indices of lipid peroxidation and chemiluminiscentia are explored in the experiment on Shinshilla rabbits and one hour later after the surgical procedure and on the third, seventh, fourteenth, thirtieth day of postoperative period. The gastrotomy performed with the help of a diathermy knife and ultrasonic scalpel leads to consider-able activation of lipid peroxidation in tissues by means of free radical lipid oxidation and to reduction of garter tissues resistance for lipid peroxidation that becomes apparent in increase of tiobarbituric acid of active products concentration and chemiluminescence’s intensity evoked by Fe2+, and Н2О2. The ultrasonic scalpel application results in less apparent patologicprocess in the zone of action than the ultrasonic scalpel application that, doubtlessly, leads to more favorable postoperative period and reduces the risk of complications development.

76-80

Authors: P.A. Garkaviy, А.Yu. Saraeva, N.I. Yabluchansky

A dependence of diastolic arterial blood pressure (DABP) changes during the clinostasis – orthostasis transition in patients with essential arterial hypertension (AH) is studied. 154 patients with AH were surveyed (58 males and 96 females) in the age of 63±7 years. Average duration of disease was 10,4±7,8 years. 48 patients diagnosed soft AH, 55 – diagnosed mild AH, 51 – diagnosed severe AH. Depending on DABP reaction in the orthostatic test patients were divided into groups: increase of DABP – group 1 (hypertonic type), unchanged DABP – group 2 (isotonic type), decrease of DABP – group 3 (hypotonic type). Criterion of DABP increase and decrease were its corresponding changes in the magnitude not less than 5 mm.hg. During the transition from clinostasis to orthostasis DABP increased in 56,5% of patients (in 62% of males and in 53,1% of females), DABP did not change in 19,5% of patients (in 13,9% of males and in 22,9% of females), DANP decreased in 24% of patients (in 24,1% of males and in 24% of females). High frequency of hypertension and hypotension types of orthostatic reactions in patients with АH indicates on the meaningfulness of aimed analysis of these types of autonomic regulation disorders during transition processes.

83-88

Authors: O.О. Gunaeva-Kruchina

During the investigation 40 out – patients with chronic ischemic heart disease (CIHD) 18 – without 22 – after aortic–coronary bypass (acb) were observed. The average period of time after operation before initial investigation comprised (13, 5) years. Patients were divided into 2 groups according to the types of dislipoproteidemia. 10 patients without асb has 2a type of dislipoproteidemia, 8 – 2b type, 15 patients after aortic–coronary bypass – 2a type, 7 – 2b type. Аll patients received atorvastatin 10 mg. Dynamics of clinical state evaluates by patient complaints of dispnea, angina pectoralis and stability of physical loards. Total cholesterol, LDL, VLDL, HDL, triglycerides, index of atherogenity were evaluated ones at 3 months. During the therapy the optimization index of lipid spectrum and clinical state indices was noted in all patients, without regarding aortic coronary bypass and grade of dislipoproteidemia. Durig the investigation after 3 months it came the decrease of lipid level and angina pectoralis attack, increase stability of physical loards.

93-96

Authors: N.V. Kalinkina

The anthracycline antibiotics cause infringement of a heart rate variability (HRV). The purpose: to study influences of nebivolol on HRV at the patients receiving anthracycline antibiotics. 73 patients (in the age of 24,5±5,1 years) receiving anthracycline antibiotics which are taking place in a remission on oncohaematological disease and not having pathologies of cardiovascular system were randomized on 2 groups: in 1-st - 37 patients receiving nebivolol in a doze 5 mg 1 times per day, in 2-nd - 36 patients without therapy by β-adrenoblocker. Control group is 30 practically healthy persons. Prior to the beginning therapy by nebivolol and after 6 months the daily monitoring of ECG with an estimation of time and spectral parameters of HRV was carried out. At initial investigation of the patients receiving anthracyclines the decrease of HRV, activation of sympathetic and deppression of parasympathic vegetative nervous system in comparison with the control was observed. At the patients accepting nebivolol through 6 months the increase of HRV, decrease of sympathetic and increase of a parasympathic tone by comparison to the 2-nd group was observed.

100-104

Authors: N.A. Kravchun

The maintenance of plasminogen activator inhibitor-1 (PAI-1) in blood serum in patients with type 2 diabetes mellitus of the senior age group with long term of disease and the role of this index in the development of cardiovascular complications were studied. The statistically significant dependence of PAI-1 on arterial hypertension, fibrinogen, triglycerides, very low density lipoproteides, body weight index and insulin resistance was determined. It was shown, that PAI-1 was a significant additional risk factor in the development of cardiovascular diseases in patients with type 2 diabetes mellitus.

109-112

Authors: V.О. Sirik

104 patients with arterial hypertension were inspected. Estimation of patients well-being, clinical criteria of arterial hypertension, interleukin-8, , E-selectin, veloergometry, EKG was conducted. The obtained results were estimated by statistical methods. It is determine, that strengthening of endothelial dysfunction in reply to veloergometry is related to development of pathological changes in endothelium which come at pro-gression of of arterial hypertension. As a criterion of prognostication of further development of arterial hyper-tension comparison of types of reaction of hemodynamics on the exercise stress with estimation of endothe-lium activity can be chosen.

117-119

Authors: Yu.K.Vasylyev

The role of the Society of the Odessa physicians, its full members in formation and its becoming of the phagocitic theory of I.I. Mechnikov is shown.

6-10

Authors: R.Ya. Abdullajev, O.V. Grishenko, V.V. Bobrytska

With the applicationof Colour and Impuls Doppler regimens the main features of utero-placental and fetal-placenta blood circulation of 68 pregnant women with placental insufficienty were examined. The main quaialitive characteristics of the critical disturbance of blood circulation were the appearance of notch on the diastolic part of Doppler spertrum of uterine artery after 20 weeks gestation and reverse blood flow in the spectrum of mid-cerebral artery and umbilical artery.

14-17

Authors: I.V. Afanasiev, Yu.S. Paraschuk

30 pregnant women research with normal function of thyroid gland and 30 pregnant women with thyrotoxicosis.Morphological research of placenta with using histochemical and stereometrical methods.It was revealed features of chronicle placental insufficiency on the background of chorion vascularisation disturbances, reinforcement of involutive and sclerotic processes in pregnant women with thyrotoxicosis. Thyrotoxicosis in pregnancy caused disturbances maturation of villous chorion, which leads chronicle placental insufficiency. Thus, thyrotoxicosis complicates current of pregnancy and requires prescription of adequate therapy.

20-23

Authors: O.V. Belkina

In the article information of radiological researches of changes of adaptations of organism of pregnant is resulted with preeclampsia and stress dysbiosi at cellular level. The conducted researches showed the decline of level of cyclic a. monophosphate (cАМP) at pregnant with preeclampsia by comparison to healthy, that testifies to exhaustion of possibilities of adaptations of organism of pregnant and can be the early signal of these violations at cellular level. A correlation analysis testifies pathogenetic connection between the stage of preeclampsia, dysbiosis and system of urgent adaptation at preeclampsia.

26-30

Authors: V.V. Bobritskaya, O.V. Grischenko, P.Ya. Abdullaev, S.O. Pozdnyakov

The article presents ultrasonographic results of transvaginal colors and impulse dopplerography in 49 women with infertility. It were studied ultrasonographic criteria of polycystic ovarian desease, unovulation and lutheal phase insufficiency. The basic parameters of diagnostics were index of resistance and degree of vascularization in the growing follicle and corpus luteum.

35-37

Authors: M.O. Bortnyi, I.O. Kramnoi, I.A. Voronzhev, R.Yu. Churilin

Analysis of x-ray postmortem pathomorphological comparison of 10 premature neonates allowed to identify hyaline membrane syndrome. Six of them developed neonatal pneumopathies (hyaline membrane diseases), 4 - hyaline membranes at pneumony. It has been confirmed the certain value of excessive ventilation respiratory volume in the pulmonary affection development mechanism.

40-44

Authors: I.A. Voronjev

The purpose of work was to study radiological displays change of lung at children of early age with patrimonial damages of CNS. Roentgenograms of chest organs of 63 children till 1 year were investigated (36 boys and 27 girls). They were treated with the diagnosis: hypoxic-ischemic defeat of the CNS, the acute period, serious current, skull cerebral trauma. For verification of the diagnosis ultrasound examination of heart and a brain, roentgenorgaphy of skull and cervical department of a backbone, and also complete clinical-laboratory examination were carried out. MRT of brain (14,3%). Dynamic observation is carried out above 24 children (38,1 %). 25,4 % of patients diagnosis confirm on post-mortem examination. Most often and early radiological attributes of shock lung (SL) were changes of pulmonary drawing (42,9 %) due to the development of the interstitial edema and infringement of a hemodynamics – 1 stage of SL. At progress of the desease small focuses (0,2-0,4 mm) were determined, somewhere merging among themselves (20,6 % – 2 stage of SL). Development of 3 stage of SL was marked in 25,4 % of patients and at X-ray it was shown by decreasing of a transparence of a pulmonary tissue, occurrence of larger focal shadows (0,6-0,8 mm) with the indistinct contours, merging among themselves, pulmonary drawing was badly differentiated. In 11,1% of cases diffuse decreasing of a lung transparence was determined, pulmonary drawing and roots were not differentiated, free strips of bronchuses on a background of blackout of pulmo-nary fields are marked also, that is characteristic for hyaline membranes – 4 stage of SL. Bronchopulmonary dysplasia, as a manifestation of 5 stage of SL was revealed in 6,3 % of patients. Associated pneumonia was determined in 30,1 % of cases. Segmentary and subsegmentary atelectases are marked in 46 % of patients. The radiological method is conducting examination in an establishment of the diagnosis of shock lung in children of early age with perinatal CNS lesions. For the given group of patients absence of precise staging and often complications such as pneumonias and atelectases is habitual.

47-50

Authors: V.V. Grabar, E.A. Yacovenko, L.G. Nazarenko, E.N. Babadganyan

The traditional antenatal preparation with estrogens is frequently not effective. In this study we applied desaminooxytocin or Pg Е1 (misoprostol) for induction of labour in patients of hight-risk pregnancy. Revealed that desaminooxytocin or prostaglandin E1 (intravaginal, intracervical or intrabuccal using) is more effective for decrease of frequency of delivery complications that estrogens. Prostaglandin E1 application is move pref-erable in case of hypertensive maternal disorders.

54-57

Authors: I.A. Guz, Y.S. Parashuk

The research was carried out to evaluate the condition of lipid metabolism in women with a fibro-myoma of the uterus and obesity. The obtained data made it possible to us ”Duphaston” drug in order to normalize the genital condition of women at the preoperative period.

61-66

Authors: V.L. Dudko, I.V. Lakhno, G. V. Storchak, O.V. Grishchenko, L.V. Dudko, N.V. Lisitsina

For the recent years the increase of vaginal candidosis morbidity frequency on a background of change in the sorts of structure of mycotical agents accompanied with obvious increase of densities Candida nonalbicans and occurrence of drug resistance to the majority of antimycotical preparations has been marked. We have carried out investigation of efficiency of intravaginal ketoconazolum application compared with unitary fluconazolum reception in gynecological patients and intravaginal natamycinum usage in pregnant woman. On the basis of the received data is proved that ketoconazolum application is an optimal theraputical method at realization of monotherapy within 10 days at pregnancy and 5 days in nonpregnant women.

69-72

Authors: E.V. Zoloto, L.A. Matytsina

Investigation of the link between psychological stress and hormonal changes, participation of the endocrine system in pathogenesis of pubertal uterine bleedings put forward the study of neurohumoral mechanisms of not only active (stress-reactions) but also passive (anti-stress reactions) which represent a way of adaptation of the organism to the permanently changing surrounding conditions. According to the literature the main danger of our time is the lack of the ability to resist the stress of current life. Important aspect of this problem is the study of hormonal anti-stress mechanisms, which in contrast to stress reactions are investigated insufficiently.

76-79

Authors: V.P. Kvashenko

Prevention and treatment of infection of urinary tract have particular significance in pregnant women, because there is dangerous for mother and child health. Under our surveillance were 60 women with different symptoms of low urinary tract infections. Was used Monural. It show high effective ness without side effects. Was provided analysis of pregnancies and deliveries out cams and it showed absence of intrauterine infections in newborns, bourns from mothers, received Monural during pregnancy.

82-86

Authors: I.Yu. Kuzmina

The researches on revealing damaging of the perinatal factors on state by fetus were carried out. It was shown that perinatal outcomes at symptoms of growth retardation fetus (SGRF) were largely determined by fetal hypoxia, expressiveness of a growth retardation of fetus and method of delivery.

89-93

Authors: I.V. Latisheva, N.Е. Heintz

Retrospective clinic and statistic analysis of 1813 history cases was made. There are 14,9% cardiovascu-lar pathology was founded. 4% parturient women had this kind of pathology. The pregnancies at this group complicated by obesity, IUGR and preeclampsia. Hysteromyoma had place at pregnant with associated cardiovascular pathology. Treatened preterm labor and pyelonephritis complicated pregnancy of patients wit vascular pathology offenly. Pregnant women with cardiovascular pathology had pathologic labor (especially cesarean section), potential perineal rupture, anomalies of uterine activity frequently than preterm membrene rupture. It was founded that pregnancy complications are not specific ant not depended on character of cardiovascular pathology. This circumstance cause nessessity furthes differential study of their pathogenesis.

99-102

Authors: S.A.Levenets, T.A.Nachotova, T.S.Vvedenskaya, A.V.Goloborodko, S.H.Cherevatova

In simultaneous investigation of hormonal status of the organism and dopplerometry of the vessels of small pelvis organs in adolescent girls, aged 15 to 17, with menstrual function disorders in the form of oligomenorrhea and secondary amenorrhea there has been established the dependence of uterus and ovaries blood supply on the levels of serum lutropin, sex hormones and cortisol. A decrease in estradol and testosterone concentrations brings to slowing down systolic blood flow in uterine and ovarian arteries, and hypercortisolemia is accompanied by blood flow acceleration only in uterine artery.

106-109

Authors: A.S. Likhachova, S.M. Korovaj, I.V. Poltoratskaya, O.V. Kogut

It was assessed with immuno-assay analysis Ig, G, M, A level in 5658 pregnant and 499 newborn infants blood serum level. It was determined high score of TORCH and STD's agents in Kharkov pregnant patients and newborn infants. We had performed a conclusion about insufficient obstetricians and gynecologists knowledge in the field of gained tests evaluation. Delayed treatment of newborn infants was associated with such incompetence. The result was high neonatal mortality rate due to infections reasons.

112-114

Authors: L.G. Nasarenko, E.A. Yakovenko, A.V. Hristich, I.A. Gadan, V.V. Grabar, O.V. Romadina, E.N. Babadganyan

The advantages of the prenatal diagnosis of fetal pathologies due to combined using of the modern methods has been shown.

118-120

Authors: Yu.S. Paraschuk, Nader Kh. N. Daoud

The condition of uterine-placental and fetal circulation was investigated in pregnant with varicose veins of the lower extremities. It was established that the parameters of uterine-placental and fetus circulation are reduced in this pathology. Complex Dollper study of uterine-placental and fetus circulation can be used in early diagnosis of pregnancy complications in women with varicose veins of the lower extremities.

123-127

Authors: S.A. Pozdnjakov, R.Ya. Abdullajev, O.V. Grischenko, V.V. Bobrytskaya

The results of transvaginal ultrasound investigation in the mode of colour and impuls Doppler from the 68 women with the adenomiosis and endometriosis are represented, the features of different degrees of the adenomiosis were found. The main criterions of endometriosis were the endometrioid getherotopies like anechogenic structures with hyperechogenic circle, grind-disperse suspension registered in cervix. The main line characteristics are frontodorsal uterine measuring, asymmetry of their size, cervical thikness. The impo-rtance of colour and impuls Doppler is in the exception of the cancerogeneous processes

130-134

Authors: V.V. Simrock, V.S. Cherkasova

A clinical inspection is conducted 53 pregnant with placental insufficiency. As a result Doppler ultra-sonography researches of fetus and placenta complex are exposed multiplying a sistolo-diastolic index in uterine arteries, arteries of umbilical cord and middle cerebral artery of fetus. Plugging of tiocetam in therapy of placental insufficiency for pregnant is instrumental in normalization of indexes of Doppler ultrasonography that in a clinical plan combines the improved fetal condition and benefitial perinatal out-come.

136-143

Authors: O.I. Shevchenko, A.V. Storchak

It was performed an assessment of possible teratogenic and embryotoxic effects on female rats. It was calculated the quantity of luteal glands in rats ovaries, quantity of alive and newborn rats, also was evaluated the lethal effects before and after implantation, macroscopic assessment to determine visible malformation, investigation of internal organs and bony skeleton. The obtained data demonstrates the absence of embryolethal effect of D-glucosamine dose 90mg/kg. We had proved the absence of visible malformations in 20 days fetuses included skeleton malformations. So it was concluded that D-glucosamine had no teratogenic effects. These results was the only first step to D-glucosamine application in perinatology.

145-152

Authors: V.I. Medved, Т.V. Avramenko, О.Е. Danylkiv, V.Е. Islamova

All measures of preventive maintenance of extragenital pathology assotiated complications in pregnant women are offered for dividing on specific and not specific. The specific preventive maintenance is directed on prevention of complications of the basic disease which character is determined by the diagnosis. Not spe-cific preventive maintenance - complex of measures allowing to prevent a numberf subclinical conditions of pregnancy which are capable to aggravate current of extragenital pathology. The measures of not specific preventive maintenance are shown to all pregnant women and their character does not depend on the diagnosis. The basic ways of prevention of deficiencies, inherent in pregnancy, venous and infectious complications are described.

156-161

Authors: I.I. Stupak, I.V. Lakhno

The main processes of synthesis and secretion of prolactin as a basic lactation hormone are considered. The assumption about perspectives of bioelement exchange investigation for the optimization of preventive maintenance methods and treatment of hypohalactia is performed.

5-9

Authors: S.V. Kalinichenko, Yu.L. Voljanski, E.M. Babich, O.B. Kolokolova, S.L. Krestezkay

The influence of the millimeter waves on the enzymatic activity of neiraminidase of different Coryne-bacteria was studied. It is established, that the effects of different diapasons of millimeter waves on the activity of this enzyme differs. The reliable stimulation of enzyme was remarked under influence of 61,0 HHz. The influence of 42.2 HHz diapasone, in contrast, inhibited the neiraminidase activity. The obtained data can be used in the extra high frequency therapy of bacteriocarriers of the toxigenic strains of Coryne-bacteria.

18-24

Authors: O.O. Olefirenko, I.V. Sleta, S.E. Galchenko

Processes of regeneration of the cirrhotic liver after cryodestruction and intraperitoneal injection of the extracts of liver and spleen from new-born piglets to rats have been studied. It has been shown that either applied methods acts on the reparation process in liver tissue. The studied methods can stop and reverse the cirrhotic process.

31-34

Authors: I.V. Sorokina, E.S. Protsenko

Morphological particularities of hepatocytes apoptosis in fetuses from mothers with diabetes type I were investigated on the basis of data of Kharkiv perinatal center and Sumy children pathologoanatomic depart-ment. As a result of performed study it was discovered that grade of fetal liver apoptosis depends on severity of mother’s diabetes I. Apoptosis index is reliably higher in liver of fetuses from mothers with I type diabetes comparing to fetuses from healthy mothers. Strong negative correlation has been established between grade of apoptosis and glycogen loss in hepatocytes’ cytoplasm. Therefore main task for endocrinologists and obstetricians must be the supply of stable compensation of carbohydrates exchange on all fetal development stages – from conception to birth.

42-47

Authors: Т.P. Yakimova, A.I. Tsivenco, E.S. Prosenco, M.S. Tomin

In the article authors presents the exspirience of making 24 hemorrhoidectomy with ultrasonic scalpel Ultraсision (Ethicon). Findings show reduction postoperative pain syndrom and minimal tissue damage in the patients that has hemorrhoidectomy with ultrasonic scalpel.

53-58

Authors: S.Yu. Bilyaevskaya, V.I. Cherniavsky, M.V. Smelianskaya, A.V. Martynov, S.D. Peremot, S.N. Davydova

The condition of immune system at patients with a stomach cancer (SC) was studied. System immu-nological infringements caused by bacterial-virus associations are revealed. In the greater measure it concerns group of patients with SC and presence НР and HHV in a tumour and in leukocytes. Such infringements are inherent in this group: considerably increased immune-rehulation index, a level of the circulation immune complex, authentic decrease of CD16, index of reaction of a blasttransformation of leucocytes.

63-66

Authors: G.N. Gerasimov

The analysis of autodermoplasty efficiency in treatment of prolonged not healing ulcers and wounds of the lower extremities at 52 patients with diabeteses mellitus using miscellaneous local treatment facilities and preparing to operations are presented in the article. On example of three groups of patients is proved higher efficiency of autodermoplasty (98.4±1.2%) when use Prostaglandin E1, a 5% -aminocapronic acid solution and gel of Solcoseril before the operation at this category of patients.

71-75

Authors: A.L. Kulik, O.I. Serikova

The study of anxiety and depression levels changes in comparison to QoLI and clinical indexes in patients with the pain form of chronic IHD with a presence or absence of depression on the stages of therapy is conducted. In all 103 patients were looked after in age 48,6±7,5. Patients, depending on the presence of depression, were parted on 2 groups. Initially in the group of patients with depression were marked increased level of anxiety, the QoLI decline, increase of mean values of stenocardia and heart failure FC, frequencies and the AH burden, on comparison with a group without depression. The standard IHD therapy improves the clinical being of patients in both groups, promoting QoLI, bringing the stenocardia and heart failure FC and diminishing the level of depression and anxiety. Thus at the patients IHD with concomitant depression as standard therapy results the change of depression, anxiety, QoLI levels and clinical status are expressed in less degree, not achieving the indexes got in the group of patients without depression. Persistent distinctions between groups testifies to the necessity of antidepressants addition to standard therapy.

77-83

Authors: Е.N. Pasko

Aim of the study of long-term inhalation glucocorticosteroids and bronchial spasmolytics therapy influence on the RF and HRV indexes in patients with bronchial asthma (BA) with an initially different forced expiratory volumes for 1 second for development of proposals on the improvement of therapy and BA control. 140 patients (58 men and 82 women) with I-IV degreeof BA were examined in ambulatory terms. Mean age – 48±2,5 years. Duration of disease – 9,3±8,1 years. RF was estimated by computer spirograph «SpiroSom» XAI, were taken into account: respiration rate frequency (RRF), forced expiratory volume for 1st, 2nd and 3rd seconds (FEV1,2,3), momentary volume speeds of the forced exhalation in the moment of 25, 50, 75% MEFL (MVS25,50,75). For the heart rate variability (HRV) analysis computer electrocardiograph «Cardiolab+» XAI was used; heart rate in 1 minute (HR); total power of spectrum (TP); spectrum power in area of high and low-frequencies (LF, HF) and relation of low and high frequencies spectrum regions powers (LF/HF) were estimated. Results showed that long-term BA therapy has positive influence on the RF indexes (FEV1,2,3, MVS25,50,75) and HRV(ТР, LF,HF, LF\HF) in all patients groups. The increase of the RF indexes depends on the initial FEV1 value and is most marked in the group of patients with FEV 1 values 80-60%. Interrelation between the FEV1 and HRV TP value in patients with BA confirms meaningfulness of regulatory mechanisms in breathing for state of health of patients and results of medical treatment.

88-92

Authors: E.A. Romanova, T.A. Sidorenko, N.I. Igumnova, L.G. Gogadze

Morphologic and cytogenetic variations of hemopoesis of rats by influence antenatal radiation was studied. Cellular composition of bone marrow of antenataly irradiated animals testify about expressed disbalance of the production, maturation and differentiation of hemopoietic cells in the all hemopoetic sprouts. It was found the increase of cells with chromosomal aberrations among the irradiated posteritys myelocariocytes.

96-100

Authors: E.D. Khvorostov, Yu.B. Zakharchenko, A.S, Shapovalov

The analysis of 4 patients with chronic calculous cholecystitis in combination with gallstone-intestinal bile fistula treatment was carried out. 3 patients had gallstone-duodenal bile fistula, 1 patient had gallstone-transverse-colon bile fistula. The diagnostics of gallstone-intestinal bile fistula in patients with chronic calculous cholecystitis is difficult and required wide investigation using expensive invasive methods. Fistula was diagnostic in the time laparoscopic cholecystectomy. The current of operative intervention was changed. Technical methods were used for the fistula removal. Gallstone-intestinal bile fistula may be removed in the time laparoscopic cholecystectomy using minilaparotomy in right subcostal area for extraction of gallbladder and suture intestinal wall without considerable trauma increase due to operation.

105-117

Authors: V.I. Padalko, T.V. Sevastyanova

In the present review modern representations about cytochrome P-450 system and roles of its major multiple forms in an organism are generalized. Drugs induction or inhibition of this system are discussed. Important for clinic interactions of drugs with P-450 enzymes are given and practical ways of prevention or minimization of negative consequences of interactions of medical products are discussed.

5-9

Authors: V.A. Babalyan

The article is reported about results of biomechanical research of rod system for osteosynthesis of tibial plateau fracture. Experimental part was held on wood models and pig’s tibia. It is found out, that rod system provides much less load for tibial plateau. Knee joint takes only 40-50% of external load.

18-24

Authors: A.V. Martynenko, A.S. Antonova, A.M. Yegorenkov

Formal mathematical procedure of developed Spectral Independent Component Analysis (SICA) of heart rate variability (HRV) allows to obtain no more than three components forming the rhythmogramm of healthy person. This fact rationally represents physiological hypotheses about regulation systems taking part in forming HRV phenomenon. Applying SICA to HRV approves itself on timing intervals form 3 to 15 minutes. Вreaking the low limit of this timing interval causes essential worsening of quality of ICA components forming the rhythmogramm. Optimal application of SICA for splitting initial registered HRV signal into components is using SICA with five-minute HRV registering protocol.

27-33

Authors: V.I. Sipitiy, O.G. Avrunin, Yu.A. Babalyan, B.V. Gunko

Three-staged method of computer guided design of implants in reconstructive surgery of fronto-orbital osseus defects was developed, based on data of spiral computed tomography of skull, which allow to pro-duce the calculation of parameters of implants in the half-automatic mode (interactive mode with the maximal degree of automation), to execute a 3D volume model of bone defect and form basic data for making of prostheses.

39-43

Authors: V.V. Balykov, E.D. Babov, A.N. Puzyryov

In women of 53,1+3,9 years old who underwent dental surgical intervention, the administration of frozened placenta pharmacon (FPP) caused the net reduction of depressive state manifestations. This effect was registered after 10 days from the moment of treatment and was pronounced in comparison with the group of age- matched control women who were only operated on without FPP administration. This period of time the blood level of tumor necrosing factor- was 1,95 times fold decreased in comparison with that one detected in group of women with traditional treatment. The obtained data are in favor of the rationality of FPP usage in patients who are treated with dental surgery intervention.

46-51

Authors: N.Т. Vatutin, N.V. Kalinkina, V.V. Ridzhok

The anthracycline antibiotics have cardiotoxic action. The purpose of this research is the study of influence trimetasidine on silent myocardial ischemia and heart rate variability (HRV) at the patients receiving anthracyclines. Material and methods: the daily monitoring of ECG with an estimation of heart rate, changes of ST segment and parameters of HRV is executed on 43 patients who received anthracyclines. The patients were divided into two groups: 1st group – 22 patients who received trimetazidine 3 times per day - 60 mg during 3 months, 2nd group – 21 patients without therapy of cardioprotection. The patients were examined twice: before the beginning of therapy with trimetazidine and 3 months later. The mean cumulative dose of anthracycline at the 1st examination – 765,4±209,1 mg/m2, at the 2nd – 1165,1±114,2 mg/m2. Results show that the anthracyclines cause the development of silent myocardial ischemia, decrease of HRV, activation of sympathetic and depression of parasympathetic nervous system. Trimetasidine therapy leads to decrease of intensity of silent ischemia, increase of HRV, decrease tone of sympathetic and increase tone of parasympathetic nervous system. Intensity of silent ischemia and disturbance of HRV were increased at the patients without therapy of cardioprotection as the doze of anthracycline was raised to more than 1000 mg/m2.

57-62

Authors: O.V. Grishchenko, I.V. Lakhno, A.T. Ovcharenko, F.S. Leontyeva, V.L. Dudko

Pregnancy is actually associated with adaptive changes of structure and function of connective tissue those are due to the fetoplacental system development. It was investigated N-acetylglucosamine and chondro¬itinsulfates blood serum level in 128 healthy pregnant women and in 34 patients with fetoplacental insufficiency. It was determined an associated with the progress of pregnancy increased level of N-acetylglucosamine and constant concentration of sulfated glycosaminoglycans. Fetoplacental insufficiency was characterized with low N-acetylglucosamine and sulfated glycosaminoglycans amount. The lack of these substances could be connected with oxidative stress which is due to the systemic inflammatory response. The drugs which could promote to the glucosamine and chondroitinsulfates synthesis and their exogenous donation are thought to be effective in fetoplacental insufficiency prevention.

68-73

Authors: E.M. Dolya

48 patients with a bronchial asthma (BA) have been surveyed during an aggravation of disease. Disturb-ances of rhythm were estimated by methods of an electrocardiogram and HMECG. Sinus tachycardy, su-praventicular and ventricular extrasystolies were also determined. Frequency of rhythm disturbances was correlated with the degree of severity disease.

78-81

Authors: I.S. Lebets, L.F. Bogmat, D.A. Kashkalda,V.L. Kashina

On the basis of clinico-biochemical study of 52 patients with systemic and limited sclerodermia it was established some similarity between clinical symptoms, syndromes and tendencies in the changes of metabo-lic findings in connective tissue structures and the content of microelements in both nosological forms. The data obtained indicate the presence of common pathogenetic mechanisms of their development which makes it posible to consider systemic and limited sclerodermias as manifestation of one disease at various stages of pathology process development.

85-90

Authors: V.O. Moyseyenko, T.D. Nykula, O.V. Biyakova, O.I. Paraphenko

The cardiointervalographic parameters in the patients with chronic glomerulonephritis and arterial hypertension at different stages of chronic renal failure were studied. One part of patients have received lighttherapy on arteria carotis zone and point E36 in the complex treatment, the other patients received microwavetherapy. Positive result of the complex treatment revealed itself in obtaining of antihypertensive effect and improving of vegetative regulation of cardio vascular system.

96-99

Authors: N.N. Popov, E.A. Romanova, S.B. Lavelin

High supression of proliferation of simulated splenocyts by bone marrow lymphocytes in vitro which appeared on the 30 day of the study was noted after the total irradiation of (CBAxC57BL)F1 mice in the dose 9 Gy and following the syngenic mielo- and lymphomielotransplant injections. More manifested suppressory activity was observed in the lymphocytes of the animals, injected with a combined transplant as compared to the cells of the animals, injected with myelocaryocytes per se. A phenotypic study of the bone marrow cells has shown that the T-depleted fraction lymphocytes, which expressed sIg-molecules and cells, characterised by a phenotype of the zero-lymphocytes, exibits suppressory properties.

105-109

Authors: S.R. Tolmachova, A.M. Kolomiets

The data concerning the consequences of diseases in 110 disabled children with different pathologies of blood circulatory organs and in 115 disabled children with rheumatoid arthritis, are presented. It has been established that the leading disturbances are visceral, metabolic, motoric and psychological disturbances. The limitation of life functions is characterized by the decrease in motoric ability, in hand motion and body motorics during the solution of everyday life tasks. Their social deficience is connected with a limitation of physical independence, mobility and capacity of receiving education. A disadaptation to inner and outer world has been verified in 37,6 % of cases. The approaches to carrying out reabilitation measures at different levels of disease consequences are given.

5-7

Authors: T.G. Avakyan

In case of the experimental compression syndrome (crush-syndrome), on the second day after decompression in the hypothalamic area of pregnant rats' brain we discovered the severe discirculatory disorders, resulting in dystrophy and necrosis of neurosecretory cells.

11-15

Authors: E.V. Port

Adhesive properties strains Pseudomonas aeruginosa allocated in 2003-2004 from clinical sicks, and also museum strains and strains allocated from agricultural animals and birds were studied. The interrelation with resistance to antibiotics these strains were found. The tendency of growth adhesion properties is marked at increased resistance to antibiotics strains Pseudomonas aeruginosa.

19-24

Authors: N.I. Sklyar

The effect of microaerophilic conditions of cultivation on sensitivity of microorganisms to etiotropic med-icines has been studied. It was shown that antibiotic resistance of bacteria and yeast-like fungi of Candida genus increased after effect of above-mentioned factor. It was found that yield sensitivity changed to moderate one for (40,0±20,0) % of Staphylococci in relation to erytromycinе, laevomycetinе, lincomycinе, furazolidonе; for (20,0±10,0) % of Escherichia coli in relation to tetracyclinе; for 100 % of yield-like fungi of Candida genus in relation to itraconazole, fluconazole, ketоconazole. Appearance of resistance has been defined for (15,0±5,0) % of Staphylococcus spp. strains in relation to furazolidonе and laevomycetinе; for (30,0±10,0) % of Candida strains in relation to amphotericin. Antibiotic sensitivity of selected objects to cefalosporins of different generations was shown to be unchanged. It was found that lysis activity of specific bacteriophages in relation to staphylococci and escherichia coli was 4-32-fold increased.

29-34

Authors: L.V. Anufrieva

Forty six patients with arterial hypertension (AH) I-III stages were investigated in out-patient department. Estimated parameters were levels of systolic and diastolic blood pressures (SBP, DBP), heart rate, general index of quality of life (GIQL) and parameters of heart rate variability (total power (TP) and low- and high-frequency ratio (LF/HF)). Patients were evaluated before treatment, during the therapy and in acute pharmacological test with amlodipin. It was shown that all patients had signifficant increase of GIQL and decrease of TP. Effective decrease of SBP and DBP was found in patients with mild and moderate AH. Pa-tients with severe AH had only depressed DBP. During the dynamic observation it was defined the decrease of total power in all patients’ groups and various LF/HF fluctuations.

37-41

Authors: L.F. Bogmat, I.M. Yakovleva, I.N. Nelina

Dependence of immunologic homeostasis on Helicobacter pylori infection was studied in 73 adolescents, aged 11 to 18, with gastroduodenal pathology against the background of systemic connective tissue dysplasia. It was established that certain changes of immunologic system in gastroduodenal pathology in this group of patients did not depend upon H. pylori presence. The main aggressive factors of gastroduodenal pathology development in adolescents with systemic connective tissue dysplasia were changes in biochemical characteristics of internal medium of the upper sections of digestive system owing to refluxes against the background of immunologic homeostasis disorders.

46-52

Authors: O.A. Vlasenko

One hundred and seventeen patients with postinfarct cardiosclerosis were examined. Left ventricular remodeling was established in 80,3 % patients. It was found to have developed concentric hypertrophy of left ventricle (LV) and moderate LV diastolic dysfunction mainly with impaired relaxation in 55,5 % patients. About 24,8% patients had more significant LV structural and geometric derangement with a tendency for the development of eccentric hypertrophy of the LV, as well as more marked systolic and diastolic dysfunction.

56-60

Authors: A.L. Kulik, O.I. Serikova, N.I. Yabluchanskiy

Based on results of 62 patients’ checkup with the pain form of ischemic heart disease and arterial hypertension the correlation analysis between the indexes of psychical and clinical status was taken. Maximum correlation level with basic clinical parameters was determined by using the Hamilton depression scale and Hospital anxiety and depression scale that allows to recommend exactly these scales for patients’ psychoemotional status estimation.

63-66

Authors: N.V. Makienko

The comparison of efficiency of amiodarone and its combinations with metoprolol and carvedilol at 102 observed in in-patient department middle age of which was 64±9 years (Msd) with permanent atrial fibrillation (AF), which complicated the IHD and AH flow according to initial FC ChHF. The patients were divided into the following groups: the first group - with II FC ChHF (40 patients) and the second group – with III FC ChHF (62 patients) with subdivision to sub-groups: sub-group A – patients taken amiodarone, A+M - amiodarone with metoprolol and A+C - amiodarone with carvedilol. By results of the AF research at patients with II FC ChHF more frequently flows on the background of soft moderate the AH or IHD degrees not higher than stable angina with II-III FC and is characterized by less duration, more higher general index quality of life (GIQL), and TP spectrum HRV at less HR. AF at patients with III FC ChHF flows more frequently on the background of moderate and heavy AH degrees and painless form IHD and is characterized by greater duration with less GIQL and TP spectrum HRV and greater HR. At AF patients with II FC ChHF initial monotherapy of amiodarone with joining of beta-adrenoblockers (BAB) according to clinical indications is possible more frequently, while at patients with III FC ChHF it is expedient to begin the therapy by combination of amiodarone with BAB, hence for patients with AF combination of amiodarone with carvedilol is more preferable than combinations with metoprolol.

74-76

Authors: V.V. Pilipchuck

The experimental work shows the results of the limb reovasography investigation in sportsmen and non-sportsmen.It has been shown that regular physical activity can increase elasticy and blood-fill of vessels.

78-82

Authors: O.О. Khyzhnyak, D.А. Kashkalda

There were observed 79 boys of 10-17 years old with arterial hypertension (AH) and hypothalamic syndrome of puberty (HSP). Activeness of collagenase, elastase and elastase inhibitors in blood serum or plasma were studied, there were revealed distinguishing characteristics in the changes of proteolytic ferments and their inhibitors activeness which, along with the estimation of clinical status and central hemodynamics, can be used as a sufficiently diagnosis of AH in these patients.

90-95

Authors: W.H. Arnold, E.A. Naumova, V.V. Koloda, M.V. Ljubichev

Dental wear is a common phenomenon in archaeological material. It has been related to the diet of the individuals. Numerous investigations have been carried out in north and middle American samples as well as African anthropological material. Not much is known about dental wear in European cultures. 11 skulls of Chervona Gusarovka, and 14 skulls of the Verchniy Saltov sites from the Kharkov area in eastern Ukraine with different foot consumption with a total number of 208 teeth were studied according to dental wear and periodontal status. Abrasion grade was determined according to international classification and statistically evaluated. Periodontal status was measured using the distance between enamel-cement boarder and alveolar crest and gingival attachment. Dental wear was significantly different (p<0.01) between both populations No significant differences were found regarding to the periodontal status. It is concluded that foot consumption had influence on dental wear, whereas it did not alter the periodontal status.