European Journal of Medicine

112-117

Authors: Sharbanu Battakova, Uken Amanbekov, Gulraikhan Miyanova, Mangaz-Dana Fazylova

The article features the research results of psychological status and the nervous system. The study was conducted on the basis of multivariate analysis of morbidity rates of the nervous system with the aim of developing of administrative actions towards the population of Ust-Kamenogorsk. The correlation analysis has shown that the of coefficients of correlation coincide with the analysis data of morbidity rates of the nervous system showing that that morbidity rates are mostly influenced by high concentration of harmful pollutants. Besides, the correlation analysis has allowed identifying the levels of pollution in the atmosphere of the city above which the interrelation between fluctuations of morbidity rates is shown and below which correlation has been not observed. From the provided data we can see that the main sources of harmful substances entering our bodies are polluted atmospheric air and soils. The study revealed that with the growth of anthropogenesis loading by toxic metals, the morbidity rates of encephalopathies of unspecified genesis and the cerebrovascular diseases increase. Changes in psycho-emotional sphere have been revealed. The novelty of research is the development of administrative procedures aimed at reduction of the disease prevalence for people living in Ust-Kamenogorsk.

124-131

Authors: Abdelkrim Berroukche, Malika Bendahmane-Salmi, Abdelkrim Badreddine Kandouci

In West of Algeria, incidence of prostate cancer (PCa) is growing and epidemiological data on benign prostatic hyperplasia (BPH) are contradictory. The prostate specific antigen (PSA) joins other tests, as digital rectal examination (DRE) and ultrasound, for better management of patient. This study aimed to assess the association of previously tests with PSA-assay in diagnosis of PCa and BPH, in West Algeria. A retrospective study was performed on two groups of 234 BPH and 56 PCa diagnosed between 2010–2012 at the urology department of the hospital in Saida. Patients underwent various diagnostic tests; DRE, ultrasound, PSA and pathological examination. BPH is more common than PCa and the most dominant age group was from 70 to 79 years. DRE was positive in 67 % of BPH and 63.3 % PCa. Ultrasound examination revealed that the prostatic structure was heterogeneous in 25.5 % of BPH and 92 % PCa. Total PSA (TPSA) was higher than the cut-off value of 4 ng / ml in 37% of BPH and 75 % PCa. Histological forms of Prostatic adenomyofibroma and prostatic adenocarcinoma were the most represented. This study shows that the combination of different tests is more efficient than using a test alone for a definitive diagnosis of PCa or BPH.

138-143

Authors: Oleksii P. Kmyta

In the article «Genetic factors of fibrinolysis violation and the role of inhibitor plasminogen activator genes polymorphism in the development of secondary thrombus bleeding complications in patients with brain injury», briefly summarized the impact of molecular-genetic mechanisms peculiarities on the system of hemostasis, the results of investigations were provide in case of thrombohemorrhagic complications appearance while PAI-1 plasma levels and computed tomographic manifestations changes in 200 patients with TBI, -675 gene polymorphism and PAI-1.

149-154

Authors: Olena C. Koloskova, Tetiana M. Bilous, Lyudmyla V. Mikaluk

It has been performed complex examination of 150 school-aged children with bronchial asthma, which included a study of exhaled breath condensate and a determination of deletions in the genes of glutathione-S-transferase (GSTM1 and GSTT1). A greater activity of bronchial inflammation manifested by increased activity of oxidative stress with the accumulation of products of oxidative modification of proteins in exhaled breath condensate has been noticed during asthma exacerbation in children with deletion polymorphism of genes GSTT1 and GSTM1 compared with patients without those genetic changes.

166-182

Authors: Vladimir N. Titov

The phylogenetic theory of general pathology postulates that notions of the biological role of arterial pressure (AP) in physiology and pathology have been subjected to inversion. The nephron’s activation of the synthesis of the components renin → angiotensin-II (A-II) and the augmentation of aldosterone secretion are directed not at an increase in AP but at preserving the volume of the piece of the third world ocean, privatized by each species, - the pool of the intercellular milieu in which, just like millions of years before, there continue to live all cells. Phylogenetically earlier organs cannot regulate the action of a later one in AP phylogenesis – a physical factor in metabolism regulation. It is not the kidneys that increase AP but the vasomotor center, which, increasing AP in the proximal segment and further hydrodynamic pressure in the distal segment of the arterial bed, seeks to reanimate the function of nephrons, the biological function of endoecology and the biological reaction of excretion. In addition to playing a major role in the biological function of locomotion, AP is a physical factor in compensating for impairments in the biological functions of homeostasis, trophology, endoecology, and adaptation. There have formed sequentially three levels of metabolic regulation in phylogenesis. At an autocrine level, there occurs a specific regulation of biochemical reactions. Within paracrinally regulated communities of cells, in the distal segment of the arterial bed, metabolism is regulated by millions of local peristaltic pumps through compensating for the biological reaction of endothelium-dependent vasodilation, microcirculation, and the action of humoral mediators and hormonal principles. In vivo from the level of the vasomotor center metabolism is non-specifically, systemically regulated by the physical factor – AP – through sympathetic activation of the heart; in the proximal segment of the arterial bed and the distal one, AP, overcoming the resistance, virtually “collapses” arterioles with impaired microcirculation. A-II acts as a vasoconstrictor only in the distal segment of the arterial bed. In the pathogenesis of essential, metabolic AH, the paracrine communities of the nephron and the kidney are involved in the realization of pathological compensation secondarily and are often “wrongfully accused”, just like the other “target organs” – the brain, the lungs, and the heart.

52-56

Authors: Aleksandr N. Bitsadze

The article studies the possibilities of the application of the principle of biological rheoencephalogram feedback in rehabilitation of patients with cerebrovascular diseases in resort environment, detects positive dynamics of rheoencephalogram measures and the symptom index in the patients with vascular dyscirculatory encephalopathy with the use of functional biocontrol, which proves the clinical efficiency of the method of treatment and rehabilitation procedures, applied in the patients with cerebrovascular diseases.

65-71

Authors: Ekaterina A. Filippova, Alexander V. Korobeynikov, Denis V. Lozhkarev

The article considers the clustering of the parameters of man’s heart rate variability. The technique of parameters calculation and diagrams of rhythmographic analysis construction are presented. The algorithm of conceptual clustering Cobweb, modified for quantitative data, is used for parameters clustering. The results of the experiments prove the efficiency of the division of the learning range of electrocardiograms into the groups similar in terms of rhythmographic parameters. The practical application of the offered method as a part of the software support of electrocardiograms analysis will enable to provide operational evaluation of the rhythmographic nature of heart function in the course of screening examinations or in the emergency medicine for diagnosing and prediction.

87-100

Authors: Alexandr N. Oleshko

Injuries are among the most frequent causes of hospitalization in emergency surgery clinics. Currently, the incidence of injuries in the population is 1:1000 per year, and the mortality rate ranges from 1.5 to 5.9 %. For treatment of wounds uses a wide range of the local application on the basis of natural and artificial ingredients. In recent decades, a number of studies devoted to the use of chitosan for the treatment of wounds of various etiologies. But data regarding the activities of chitosan-based materials on the treatment of wounds of mechanical etiology in age aspect are pure. The aim of our research – the study of the parameters of wound surface in animals of different ages during the application of chitosan membranes. The experiment was conducted on 180 laboratory animals – young, mature and old age, which simulated mechanical trauma in interscapullar area. Experimental series were carried out daily applique innovative chitosan membranes. To control the process of skin regeneration was used method of planimetric study. Age features of mechanical etiology wound healing are to reduce the speed of cleaning the surface of the necrotic mass and slowing the formation of the epithelial layer. Application of chitosan membranes for the treatment of mechanical trauma leads to an acceleration of cleansing the wound from necrotic tissue, increased the speed of transformation of granulation in the connective tissue and as a result – complete epithelialization of the defect without scar formation.

4-7

Authors: Mohamed S. Al-Braich, Nada K. Al-Husaini, Sama H. M. Saleh, Munira F. Awn

Adiponectin is protein secreted from adipose tissue and plays important role in regulating glucose level as well as fatty acid breakdown. Adipose tissue has been considered an important endocrine organ. Adiponectin has been shown to completely reverse insulin resistance. A total of sixty subjects involved in this study to examine the regulatory roles of adiponectin concentration in diabetic type II postmenopausal women and to study the correlation between the parameters (serum glucose, cholesterol and triglyceride). Thirty of each diabetic women (BMI<30) and healthy postmenopausal women (BMI<30) were selected from Baghdad teaching hospital in Baghdad/ Iraq. ELISA (enzyme linked immune sorbent assay) technique was used for the measurement of serum adiponectin. Blood glucose, cholesterol and triglyceride were determined by using colorimetric method. Results showed that the level of serum adiponectin in diabetic postmenopausal women were significantly (P < 0.01) lower than that of non diabetic postmenopausal women. Serum glucose in diabetic postmenopausal women was significantly (P < 0.01) higher than non-diabetic women. The present study indicates the possibility of future development of new anti-diabetic agents that act independent of insulin action.

17-28

Authors: Natalia H. Horovenko, Svitlana V. Podolska, Zoryana R. Kocherha

It has been established that the frequency of polymorphic variants of GSTM1 "+" genes was 43.70 % and the frequency of polymorphic variants of GSTM1 "-"genes made up 56.30 % correspondingly in all newborns in the region, without division into ecological zones. Speaking about GSTT1genes the frequencies of polymorphic variants of GSTТ1«+» and GSTТ1«-» were 80.67 % and 19.33 % correspondingly. Positive micro-nucleus test was found in none of the carriers of GSTТ1«-» polymorphic variant. GSTT1«+» allelic variant was found in all newborns with negative micro-nucleus test. 78.38 % predominance in associations of GSTM1«+»/GSTT1 genotypes is characteristic of newborns with negative micro-nucleus test. Our studies have shown the diagnostic value of molecular-genetic testing in conjunction with the micro-nucleus testing for predicting newborns’ genome sensitivity to total exposure of environmental factors.

43-48

Authors: Mikhail Yu. Vereshchagin, Aleksandr U. Minkin

There is a growing number of patients with malignant tumors of nasal cavity and paranasal sinuses. Majority of patients with this pathology are hospitalized with III-IV cancer stages. There is no tendency to decrease the advanced stage of cancer. The efficiency of patients’ treatment can be increased by early diagnostics. The main reason of delayed diagnostics is insufficient oncologic alarm in primary health care. While the background prodromic cancer processes are morphologically detected in 56.7 % of patients, the issues of treatment policy during cavity and paranasal sinuses premalignancy are still unsettled. Chronic polypous rhinosinusitis is one of the most frequent background process of cancer of nasal cavity and paranasal sinuses. Rhinosinusitis morbidity is high; the growth of its incidence is 2–4 % per year in the last decade. There are few works, considering polypous rhinosinusitis as premalignant condition.

64-68

Authors: Svetlana M. Avtomeenko, Guram V. Hadzhava, Irina V. Suglobova

Combined use of magneto- laser therapy, intravaginal and cutaneous electrical neurostimulation and physical therapy by workstation "KLMP-01 “AndroGin" and natural physical therapeutic factors in the form of hydrogen sulfide vaginal irrigations and full baths in the course of pre-conceptual preparation of 270 women suffering from chronic inflammatory diseases of the pelvic organs, provided the pregnancy in 73.6 % of patients. Transcranial electrostimulation of these women during pregnancy has reduced the incidence and degree of progression of such gestational pathologies as chronic placental insufficiency in 3.2 times, preeclampsia in 4.6 times, the frequency of cesarean section in 1.4 times.

76-83

Authors: Anatolii T. Bykov, Victoria A. Krutova

The study examines the frequency of co-occurring somatic diseases in patients with gynecological disorders of menstrual function. The study presents a detailed analysis of resort factors of healing areas in Krasnodar Region, which can be successfully used in differential regenerative treatment of patients with co-occurring extragenital pathologies.

95-100

Authors: Irina P. Ryzhov, Andrey A. Prisnyi, Mariya S. Salivonchik

The biocompatibility of materials of construction materials of dentures, used for the treatment of patients without teeth is one of the key issues of modern dentistry. Thermoplastic polymers are new members of the basic polymers and is currently poorly understood. Chemical nature of these materials is a major positive factor in harmless dentures. However, the ability of microorganisms to adsorb on the surface and penetrate into the structure of a dental prosthesis depends on many factors, including the quality of their processing. In this study, the issues of quality of surface polymers after finishing at the macro and micro levels were reviewed. These aspects are crucial for long-term operation of harmless prosthetic in the oral cavity.

4-10

Authors: Galina D. Bryukhanova, Andrey A. Schetkin

Food industry stirs close interest of researches due to the extension and deepening of the problems of ecologic, microbiologic, epidemiologic safety of food industry and intake, determined by many social, anthropogenic and natural factors: change of human food ration; world economy globalization and, in particular, food market due to the penetration of pathogens, toxins into the new territories; adaptation of pathogenic agents to food storage conditions and new factors of transmission and other reasons. As a result, food-borne diseases significantly determine the increase of infectious and non-infectious pathologies in the world, including economically developed countries. The paper presents the data on the existing systems of catering risk control, current data on the role of some food pathogens in alimentary outbreaks, offers measures to increase food safety in the Russian Federation on both national and federal levels in terms of its membership in World Trade Organization.

15-21

Authors: Kirill V. Gordon, Eduard S. Khudoev

Breast prosthesis with aesthetic purposes is widespread throughout the world and has been rapidly spreading within Russia in recent years. Since the frequency of breast postoperative complications and repeated surgery does not tend to decrease, it is advisable to examine patients more thoroughly to choose the appropriate surgery. Postoperative medical rehabilitation is also required to improve the psycho-emotional state, prevent early and delayed postoperative complications and increase the quality of life of women. This technology can be successfully used in regenerative medicine.

37-47

Authors: Yurii A. Kucheryavyi, Zalina F. Tibilova, Dmitrii N. Andreev, Andrei V. Smirnov, Igor' V. Maev

The research is aimed at the evaluation of the role of SPINK1 gene mutations in the development of different etiologic variants of chronic pacreatitis (CP). The examination of 240 CP patients and 107 healthy people, constituting the control group (CG) was undertaken. All the patients underwent general and biochemical blood analysis, clinical urinalysis, standard coprological examination, immunoenzyme method of fecal elastase-1 determination, esophagogastroduodenoscopy (EGC), ultrasound investigation and/or computer tomography (CT) of abdominal cavity organs and genetic research on mutation N34S (AAT>AGT) identification in SPINK1 gene, using the method of restriction analysis. N34S mutation was determined in 22 (9.2 %) CP patients and in 3 (2.8 %) CG people. The upper frequency of N34S mutation was determined in patients with toxic and idiopathic CP, which has reached 16.7 % in total and 13.3 % for homozygotes. High frequency of N34S mutation was registered in patients with complicated forms of idiopathic CP, which can increase the risk of disease complication.